High prevalence of Staphylococcus aureus nasal carriage among children in Szolnok, Hungary

Laub, Krisztina; Tóthpál, Adrienn; Kovács, Eszter; Sahin-Tóth, Judit; Horváth, Andrea; Kardos, Szilvia; Dobay, Orsolya

doi:10.1556/030.65.2018.001

Cited by 17 publications

(15 citation statements)

References 23 publications

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“…This prospective cohort study identified risk factors for MDR S. aureus carriage in newborn infants and assessed the risk of MDR S. aureus vaginal carriage of mothers for MDR S. aureus carriage in their newborn infants. The gender of the newborn infants was not associated with MDR S. aureus isolates in this study, which was different to previous studies (22, 23). The mechanism between gender and MDR S. aureus carriage requires further exploration.…”

Section: Discussioncontrasting

confidence: 99%

Maternal-Infant Correlation of Multidrug-Resistant Staphylococcus aureus Carriage: A Prospective Cohort Study

Lin

Yao

2018

Front. Pediatr.

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Objectives: We aim to assess the correlation of multidrug-resistant Staphylococcus aureus (MDR S. aureus) carriage between mothers and their newborn infants.Materials and Methods: We conducted a prospective cohort study of mothers and their newborn infants in two hospitals in Shenzhen, China, from August to November 2015. We collected demographic and clinical information from mothers and newborn infants by face-to-face questionnaires and medical datasets. Serial swabs were collected from mothers and their newborn infants for further experiments. Maternal-infant correlation was assessed using the Poisson regression model.Results: The prevalence of MDR S. aureus vaginal carriage in mothers was 4.7% (86/1834). The incidence of MDR S. aureus carriage in newborn infants was 1.3% (23/1834). The adjusted relative risk and 95% confidence interval of maternal-infant MDR S. aureus carriage was 7.63 (2.99–19.49). Six MDR S. aureus maternal-infant pairs were concordant. The phenotypic and molecular characteristics of MDR S. aureus isolates were similar between mothers and their newborn infants.Conclusion: MDR S. aureus vaginal carriage in mothers was associated with an increased risk for MDR S. aureus carriage in their newborn infants.

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Section: Discussioncontrasting

confidence: 99%

Maternal-Infant Correlation of Multidrug-Resistant Staphylococcus aureus Carriage: A Prospective Cohort Study

Lin

Yao

2018

Front. Pediatr.

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“…Older children and young adults, as well as males, are known to be more frequently colonized by S. aureus. 9,[12][13][14][15] As we have observed, other authors have also reported higher colonization rates in urban settings in asymptomatic children or among adults with SSTIs. 16,17 In our study, patients with chronic conditions presented higher rates of colonization, although most of them were atopic children.…”

Section: Discussionsupporting

confidence: 84%

“…Recent studies performed in different regions of Europe have also reported high S. aureus colonization rates in children (34% to 53%). 13,32 These data suggest that S. aureus colonization could be increasing in children in our continent. In addition, although the isolation of MRSA was low in our cohort (1.4%), it is substantially higher than the rates reported by several authors in European children and even in adults (0.14-0.8%) 9,13,26,32 which is a concerning issue.…”

Section: Discussionmentioning

confidence: 75%

Staphylococcus aureus Nasal Colonization in Spanish Children. The COSACO Nationwide Surveillance Study

Rosal

Méndez-Echevarría

Vera

et al. 2020

IDR

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Objective To assess the prevalence and risk factors for S. aureus and methicillin-resistant S. aureus (MRSA) nasal colonization in Spanish children. Methods Cross-sectional study of patients <14 years from primary care centers all over Spain. Clinical data and nasal aspirates were collected from March to July 2018. Results A total of 1876 patients were enrolled. Prevalence of S. aureus and MRSA colonization were 33% (95% CI 30.9–35.1) and 1.44% (95% CI 0.9–2), respectively. Thirty-three percent of the children (633/1876) presented chronic conditions, mainly atopic dermatitis, asthma and/or allergy (524/633). Factors associated with S. aureus colonization were age ≥5 years (OR 1.10, 95% CI 1.07–1.12), male sex (OR 1.43, 95% CI 1.17–1.76), urban setting (OR 1.46, 95% CI 1.08–1.97) and the presence of asthma, atopic dermatitis or allergies (OR 1.25; 95% CI: 1.093–1.43). Rural residence was the only factor associated with MRSA colonization (OR 3.62, 95% CI 1.57–8.36). MRSA was more frequently resistant than methicillin-susceptible S. aureus to ciprofloxacin [41.2% vs 2.6%; p<0.0001], clindamycin [26% vs 16.9%; p=0.39], and mupirocin [14.3% vs 6.7%; p=0.18]. None of the MRSA strains was resistant to tetracycline, fosfomycin, vancomycin or daptomycin. Conclusions The main risk factors for S. aureus colonization in Spanish children are being above five years of age, male gender, atopic dermatitis, asthma or allergy, and residence in urban areas. MRSA colonization is low, but higher than in other European countries and is associated with rural settings.

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“…According to the MLST database, members of ST45 were previously isolated from human carriers in Germany, Philippines and from an asymptomatic dog in the USA [28]. ST45 was also identified earlier in our carriage studies (represented by both MRSAs and MSSAs), from children and adults [62,63], veterinarians and dogs [unpublished], so it seems to be a common carried type in Hungary, being present for a long time. This assumption is further supported by the fact that Q47 and Q85 were isolated from two different geographical areas in Hungary.…”

Section: Plos Onesupporting

confidence: 56%

Whole genome sequencing of coagulase positive staphylococci from a dog-and-owner screening survey

et al. 2021

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Background Staphylococcus aureus and S. pseudintermedius are the two most common coagulase positive staphylococci (CPS). S. aureus is more prevalent among humans, whereas S. pseudintermedius is more commonly isolated from dogs, however, both can cause various community and hospital acquired diseases in humans. Methods In the current study we screened 102 dogs and 84 owners in Hungary. We tested the antibiotic susceptibility of the strains and in order to get a better picture of the clonal relationship of the strains, we used pulsed-field gel electrophoresis. In addition, three pairs of isolates with identical PFGE patterns were whole genome sequenced, MLST and spa types were established. Results Carriage rate of S. aureus was 23.8% in humans and 4.9% in dogs and two cases of co-carriage were found among dogs and owners. S. pseudintermedius carriage rate was 2.4% and 34.3%, respectively, with only one co-carriage. The isolates were generally rather susceptible to the tested antibiotics, but high tetracycline resistance of S. pseudintermedius strains was noted. The co-carried isolates shared almost the same resistance genes (including tet(K), bla(Z), norA, mepR, lmrS, fosB) and virulence gene pattern. Apart from the common staphylococcal enzymes and cytotoxins, we found enterotoxins and exfoliative toxins as well. The two S. aureus pairs belonged to ST45-t630, ST45-t671 and ST15-t084, ST15-t084, respectively. The co-carried S. pseudintermedius isolates shared the same housekeeping gene alleles determining a novel sequence type ST1685. Conclusions Based on the genomic data, dog-owner co-carried strains displayed only insignificant differences therefore provided evidence for potential human-to-dog and dog-to-human transmission.

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High prevalence of Staphylococcus aureus nasal carriage among children in Szolnok, Hungary

Cited by 17 publications

References 23 publications

Maternal-Infant Correlation of Multidrug-Resistant Staphylococcus aureus Carriage: A Prospective Cohort Study

Maternal-Infant Correlation of Multidrug-Resistant Staphylococcus aureus Carriage: A Prospective Cohort Study

Staphylococcus aureus Nasal Colonization in Spanish Children. The COSACO Nationwide Surveillance Study

Whole genome sequencing of coagulase positive staphylococci from a dog-and-owner screening survey

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