High prevalence of ST121 in community-associated methicillin-susceptible Staphylococcus aureus lineages responsible for skin and soft tissue infections in Portuguese children

Conceição, Teresa; Aires-de-Sousa, Marta; Pona, N.; Brito, Maria João; Barradas, C.; Coelho, Raquel; Sardinha, Teresa; Sancho, Luísa; Sousa, Germano de; Machado, Miguel; Lencastre, Hermı́nia de

doi:10.1007/s10096-010-1087-8

Cited by 37 publications

(29 citation statements)

References 38 publications

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“…27 Moreover, the lineage t2155-ST121-CC121 found in one of our MSSA strains, has also been detected among MRSA implicated in skin and soft tissues infections. 32 Interestingly, this strain was isolated from a skin lesion of an individual who worked sporadically in the farm (Case 6). In the same line, many studies have associated the MRSA-ST22 genetic lineage with frequent infections in Europe.…”

Section: Discussionmentioning

confidence: 98%

Molecular characterization of Staphylococcus aureus isolated from humans related to a livestock farm in Spain, with detection of MRSA-CC130 carrying mecC gene: A zoonotic case?

Benito

Gómez

Aspíroz

et al. 2016

Enfermedades Infecciosas y Microbiología Clínica

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Section: Discussionmentioning

confidence: 98%

Molecular characterization of Staphylococcus aureus isolated from humans related to a livestock farm in Spain, with detection of MRSA-CC130 carrying mecC gene: A zoonotic case?

Benito

Gómez

Aspíroz

et al. 2016

Enfermedades Infecciosas y Microbiología Clínica

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“…On the other hand, probably the prevalence of MSSA is also dependent on the type of infection analyzed, since in another study performed in Portugal it was shown that the most prevalent clone in skin and soft tissue infections was ST121. 12 This clonal type was neither observed in the 2006 or 2011 surveys in Portugal in which bacteremia isolates were recovered and analyzed. 22 Another evidence for the dynamic nature of MSSA population is the finding in our study of four spa types that were common between MSSA and MRSA, associated to ST5, ST8, and ST22.…”

Section: Dynamics Of Mssa Population and Its Relatedness To Mrsamentioning

confidence: 97%

Massive Dissemination of Methicillin ResistantStaphylococcus aureusin Bloodstream Infections in a High MRSA Prevalence Country: Establishment and Diversification of EMRSA-15

Faria

Miragaia

Lencastre

2013

Microbial Drug Resistance

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Portugal is the European country with the highest prevalence of methicillin resistant Staphylococcus aureus (MRSA), in which EMRSA-15 (ST22-IVh) has been the dominant clone since soon after its introduction in Portuguese hospitals in 2001. In this study, we intend to not only, assess the evolution of the invasive MRSA in Portuguese hospitals, but also to evaluate the invasive methicillin susceptible S. aureus (MSSA) population and the relationship between both populations. In the current study, two major MRSA clones were identified: EMRSA-15 that has been dominant for more than 10 years and accounts for 75% of the MRSA isolates, and ST105-II, a clone related with the New York/Japan clone (ST5-II). In contrast, among MSSA, several clonal backgrounds were identified. Despite of the massive predominance of EMRSA-15 in the last decade, an increase in spa diversity has been observed in the last few years, which suggests a recent and local diversification of this clone. Interestingly, MRSA and MSSA populations with related clonal backgrounds appear to have increased as a result of the dissemination of MRSA to the community environment.

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“…Moreover, this clone had been also reported in China, Nigeria and Germany Conceição et al, 2011;Schefold et al, 2007). It is noteworthy that two PVL -positive ST 121-SCCmec V-MRSA isolates emerged in Cambodia (Chheng et al, 2009).…”

Section: Mlst-ccmentioning

confidence: 62%

“…The ST121 was one of the predominant lineages of PVL-positive MSSA in the world (Rasigade et al, 2010) and the dominant clone in MSSA throughout Russia and Portugal (Vorobieva et al, 2008;Conceição et al, 2011). Moreover, this clone had been also reported in China, Nigeria and Germany Conceição et al, 2011;Schefold et al, 2007).…”

Section: Mlst-ccmentioning

confidence: 87%

Molecular characteristic of Staphylococcus aureus isolates in a Chinese teaching hospital

Ma¹,

Chen²,

Zhou³

et al. 2011

Afr. J. Microbiol. Res.

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The aim of this study is to investigate the genetic backgrounds of methicillin susceptible Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA) and heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) isolates isolated from clinical specimens of the patients with verified infections in a Chinese teaching hospital. Macro E test (MET) was used to detect hVISA and multilocus sequence typing (MLST) was used to determine the STs of the selected isolates. The genotypes of SCCmec were determined by multiplex polymerase chain reaction (PCR) in MRSA isolates. Panton-valentine leucocidin (PVL) genes were also detected by PCR. Among 273 S. aureus isolates, hospital-acquired methicillin-resistant Staphylococcus aureus (HA-MRSA), community-associated methicillin-resistant S. aureus (CA-MRSA), hospital-acquired methicillin susceptible Staphylococcus aureus (HA-MSSA) and community-associated methicillin susceptible Staphylococcus aureus (CA-MSSA) isolates accounted for 55.6, 1.5, 36.3, and 6.6%, respectively. Nine isolates were confirmed as hVISA by MET. Among 60 HA-MRSA isolates, ST239-MRSA-III was the most prevalent clone accounting for 51.7%, followed by ST5-MRSA-II clone. Fifty percentage and 22.2% of CA-MSSA isolates were found to be ST121 and ST88. ST239-MRSA-III was the predominant clone in hVISA isolates. However, no predominant ST type was found in HA-MSSA isolates. Of 9 PVL-positive strains, ST88 was the most prevalent ST (50.0%; 4/8), followed by ST121 (33.3%; 3/9), ST5 (4.5%; 1/22) and ST239 (2.6%; 1/39). In conclusion, ST239-III was the major pandemic clone in hVISA and HA-MRSA and spread in China. ST5-emerging rapidly in China had remained stable viability.

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High prevalence of ST121 in community-associated methicillin-susceptible Staphylococcus aureus lineages responsible for skin and soft tissue infections in Portuguese children

Abstract: In order to evaluate the incidence of communityassociated methicillin-resistant

Cited by 37 publications

References 38 publications

Molecular characterization of Staphylococcus aureus isolated from humans related to a livestock farm in Spain, with detection of MRSA-CC130 carrying mecC gene: A zoonotic case?

Molecular characterization of Staphylococcus aureus isolated from humans related to a livestock farm in Spain, with detection of MRSA-CC130 carrying mecC gene: A zoonotic case?

Massive Dissemination of Methicillin ResistantStaphylococcus aureusin Bloodstream Infections in a High MRSA Prevalence Country: Establishment and Diversification of EMRSA-15

Molecular characteristic of Staphylococcus aureus isolates in a Chinese teaching hospital

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