High Prevalence of Sleep Disorders at the Time of CKD Diagnosis

Santo, Rosa Maria De; Cesare, Concetta Maria; Bartiromo, Marilú; Cirillo, Massimo

doi:10.1053/j.jrn.2007.10.021

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…The authors hypothesized that psychological factors, such as depressive mood, might be the main cause of altered sleep in nondialyzed CRF patients 9. Further studies supported this suggestion 10, 12, 13. Although psychological status may have a relevant role in impairing sleep quality in nondialyzed CRF patients, the occurrence of intrinsic sleep disturbances in these subjects should not be overlooked.…”

Section: Discussionmentioning

confidence: 96%

“…Because recent epidemiological and polysomnographic studies showed that nocturnal rest is impaired in nondialyzed CRF patients, the interest of researchers shifted toward the predialytic phase of CRF 9–13. Most of these surveys identified psychological factors as the only predictor of disrupted sleep in this population,9, 10, 12, 13 but other studies demonstrated a high prevalence of intrinsic sleep complaints, such as RLS, in nondialyzed CRF patients, both in adults and in children 11, 14…”

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confidence: 99%

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A case‐control study on restless legs syndrome in nondialyzed patients with chronic renal failure

Merlino

Lorenzut²,

Gigli

et al. 2010

Movement Disorders

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Restless legs syndrome (RLS) is a possible consequence of end-stage renal disease. However, conclusive data on the association between RLS and chronic renal failure (CRF) in nondialyzed patients are still lacking. The aims of this study were: (1) to look for an association between RLS and CRF in nondialyzed patients; (2) to analyze the characteristics of RLS and its consequences on nocturnal rest in nondialyzed patients with CRF; (3) to identify possible predictors of RLS occurrence in nondialyzed patients with CRF. We recruited 138 nondialyzed patients with CRF (mean age: 69.8 +/- 11.7 years; male: 61.6%) and 151 controls (mean age: 60.2 +/- 18.6 years; male: 42.4%). An expert in sleep medicine investigated the presence of RLS by means of a face-to-face interview. Fifteen nondialyzed CRF patients and five controls were diagnosed as RLS affected. A multivariate analysis confirmed that RLS was independently associated with CRF in nondialyzed patients (P = 0.004). CRF patients RLS(+) were more commonly women and showed the presence of an iron deficiency compared with the RLS(-) ones. Independent predictors of RLS in nondialyzed CRF patients were: female sex (OR: 10.7, 95% CI: 2.2-31.3; P = 0.004) and percentage of transferrin saturation (OR: 0.6, 95% CI: 0.4-0.9; P = 0.04). This is the first case-control study able to recognize an association between RLS and CRF in patients not yet on dialysis. Nephrologists should investigate and treat RLS in their nondialyzed patients with CRF. In particular, physicians should carefully investigate women and patients with iron deficiency in the presence of RLS symptoms.

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Section: Discussionmentioning

confidence: 96%

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confidence: 99%

A case‐control study on restless legs syndrome in nondialyzed patients with chronic renal failure

Merlino

Lorenzut²,

Gigli

et al. 2010

Movement Disorders

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“…6,51 Interestingly, similar to the adult experience, we also found sleep problems to be common even in early stages of CKD. 52,53 The increased frequency of sleep disorders might reflect some undetermined underlying pathogenesis inherent in CKD or might be secondary to various associated comorbidities. In fact, adult studies have suggested that the sleep problems of patients with CKD and those receiving chronic intermittent daytime hemodialysis may have different etiologies.…”

Section: Commentmentioning

confidence: 99%

Sleep Disturbances in Children and Adolescents With Non–Dialysis-Dependent Chronic Kidney Disease

Sinha¹,

Davis²,

Matsuda‐Abedini³

2009

Arch Pediatr Adolesc Med

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“…A recent study of pediatric patients on dialysis showed increased rates of SDB, RLS and PLMD above the estimated baseline rates for these disorders in otherwise healthy children [2]. Other studies have investigated the prevalence of sleep disorders in adult patients with chronic kidney disease (CKD) not on dialysis, and, again, sleep disorders were more common than in the general population [3,4]. To date, no such study has been done on children with CKD, on or off dialysis.…”

Section: Introductionmentioning

confidence: 99%

Restless legs syndrome in pediatric patients with chronic kidney disease

et al. 2009

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Sleep disorders have been shown to be more prevalent in adults and children with chronic kidney disease (CKD) and on dialysis. To date, the prevalence and impact of restless legs syndrome (RLS) in various stages of CKD has not been evaluated. The object of this study was to determine the prevalence of RLS in children with CKD in different stages, and to evaluate its impact on sleep and daytime functioning. We conducted a clinic-based or telephone survey of 26 patients in varying stages of CKD to assess for RLS, sleep schedule, and daytime sleepiness. Thirty-five percent of children met criteria for RLS, the majority being in CKD stages 1-4. There were no significant differences seen in sleep schedule and daytime sleepiness between those children with or without RLS. We found that there is an increased prevalence of RLS in children with CKD compared to the general population. This suggests that children with all stages of CKD should be routinely screened for RLS symptoms.

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High Prevalence of Sleep Disorders at the Time of CKD Diagnosis

Cited by 8 publications

References 19 publications

A case‐control study on restless legs syndrome in nondialyzed patients with chronic renal failure

A case‐control study on restless legs syndrome in nondialyzed patients with chronic renal failure

Sleep Disturbances in Children and Adolescents With Non–Dialysis-Dependent Chronic Kidney Disease

Restless legs syndrome in pediatric patients with chronic kidney disease

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