High Prevalence of Serum Antibodies to Equine Infectious Anemia Virus Reverse Transcriptase

DeVico, Anthony L.; Issel, Charles J.; Grice, Stuart F. J. Le; Payne, Susan; Montelaro, Ronald C.; Sarngadharan, M. G.

doi:10.1089/aid.1993.9.7

Cited by 2 publications

(1 citation statement)

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“…Although p26 is the most abundant protein in the virion, the humoral response against p26 is 10 to 100-fold lower than the reactivity against gp90 and gp45 [51,123]. Antibodies that recognize EIAV reverse transcriptase have also been described in experimentally and naturally EIAV infected animals [35].…”

Section: Immune Control Of Eiav Infection and Replicationmentioning

confidence: 99%

Equine Infectious Anemia Virus (EIAV): what has HIV?s country cousin got to tell us?

2004

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-Equine Infectious Anemia Virus (EIAV) is a lentivirus, of the Retrovirus family, with an almost worldwide distribution, infecting equids. It causes a persistent infection characterized by recurring febrile episodes associating viremia, fever, thrombocytopenia, and wasting symptoms. The disease is experimentally reproducible by inoculation of Shetland ponies or horses with EIAV pathogenic strains. Among lentiviruses, EIAV is unique in that, despite a rapid virus replication and antigenic variation, most animals progress from a chronic stage characterized by recurring peaks of viremia and fever to an asymptomatic stage of infection. The inapparent carriers remain infective for life, as demonstrated by experimental transfer of blood to naive animals. The understanding of the correlates of this immune control is of great interest in defining vaccine strategies. Research on EIAV, this "country cousin" of HIV (Human Immunodeficiency Virus), over the last five decades has produced some interesting results on natural immunological control of lentivirus replication and disease and on the nature and role of virus variation in persistence and pathogenesis. These studies are of interest in the context of HIV and efforts to develop a vaccine. This review will focus on some of the most recent results. equine infectious anemia virus / lentivirus / equids / vaccine / viral evolution

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Section: Immune Control Of Eiav Infection and Replicationmentioning

confidence: 99%