High prevalence of SARS-CoV-2 Infection Among Symptomatic Healthcare Workers in a large university tertiary hospital in São Paulo, Brazil

Abstract

Background: Latin America became the epicenter of the COVID-19 pandemic in May 2020, mostly driven by Brazil's situation. Healthcare workers are at increased risk of SARS-CoV-2 infection, experiencing a significant burden from COVID-19. Identifying and understanding the clinical characteristics and risk factors associated with infection are of paramount importance to inform screening strategies and infection control practices in this scenario. The aims of this study were to investigate the prevalence and clinical characteristics of healthcare workers with COVID-19 symptoms. Methods: Between March 21st and May 22nd, 2020 a cross-sectional study was performed in a tertiary university hospital in São Paulo. Prevalence of SARS-CoV-2 infection among health care workers with COVID-19 symptoms was determined by RT-PCR testing on nasopharyngeal and oropharyngeal samples. Participants were asked to complete an electronic structured questionnaire including clinical and demographic data. Results: Overall, 125 (42.37%) of 295 symptomatic healthcare workers tested positive for SARS-CoV-2. Over the 10-week study period, positivity rates varied from 22.2% (CI 95% 15.9% - 60.3%) in the second week to 55.9% (CI 95% 43.2% - 68.6%) in the sixth week, reaching a plateau (38% - 46%) thereafter. Median (SD) age was 34.2 ( 9.9) years and 205 (69.5%) were female. We did not find significant differences in the prevalence of the most commonly reported underlying medical condition among healthcare workers that tested positive or negative for SARS-CoV-2 infection. After multivariate analysis, using logistic regression, anosmia (OR 4.4 95% C.I. 2.21 - 8.74) and ocular pain (OR 1.95 C.I. 95% 1.14 - 3.33) were the only symptoms independently associated with positivity for SARS-CoV-2 infection. Follow-up information on clinical outcomes showed that 9 (7.2%) healthcare workers were hospitalized (seven were male) and 2 (1.6%) died.Conclusions: The findings of this study confirmed the high burden of SARS-CoV-2 infection among healthcare workers in the hardest hit city by the pandemic in Latin America. Anosmia and ocular pain were symptoms independently associated with COVID-19 diagnosis. In low and middle-income countries, where limited availability of tests is frequent, these findings may contribute to optimize a targeted symptom-oriented screening strategy.

Severe acute respiratory syndrome coronavirus 2 infection among healthcare workers in a tertiary public hospital in Curitiba, Brazil

“…These findings show a higher infection rate than those previously reported in other countries, such as 11%, 8.8, and 7,1% in Spain, Italy, and Turkey, respectively 4 , 5 , 8 . However, Buonafine et al 9 in São Paulo, Brazil, reported 42.4% confirmed COVID-19 infections among symptomatic HCWs, while our findings demonstrated a 32.7% positivity rate among symptomatic HCWs.…”

Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences

“…The mean or median age of subjects in the 104 studies ranged from 26 to 77 years. Studies reported on subjects from multiple countries (n=5), [15][16][17][18][19] from Australia (n=1), 20 Belgium (n=1), 21 Brazil (n=1), 22 Canada (n=2), 23,24 China (n=7), 2,19,[25][26][27][28][29] France (n=12), 19,[30][31][32][33][34][35][36][37][38][39] Germany (n=10), 19,[40][41][42][43][44][45][46] Greece (n=1), 49 Iceland (n=1), 50 India (n=2) 51,52 Iran (n=3), [53][54][55] Iraq (n=2), 56,57 Israel (n=4), [58][59][60][61] Italy (n=19),…”

High SARS-CoV-2 seroprevalence in persons experiencing homelessness and shelter workers from a day-shelter in São Paulo, Brazil

“…The shelter workers evaluated in this study included healthcare and social assistance professionals, cooking, and maintenance personal. It has been well known that healthcare professionals are at a greater risk of exposure to SARS-CoV-2 than the general population [ 22 ]. Strikingly, the seroprevalence of 47.1% (41/87) reported herein is higher than those of healthcare workers from other countries, ranging from 0 to 45.3% in a systematic review of 49 studies from North America, Asia, Europe, and Africa [ 23 ].…”