High Prevalence of Pituitary Adenomas: A Cross-Sectional Study in the Province of Liège, Belgium

Daly, Adrian; Rixhon, Martine; Adam, Christelle; Dempegioti, Anastasia; Tichomirowa, María A.; Beckers, Albert

doi:10.1210/jc.2006-1668

Cited by 907 publications

(606 citation statements)

References 14 publications

(20 reference statements)

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“…1,2 Virtually all organs or tissues are affected directly or indirectly by the hormones secreted by the anterior pituitary. 3,4 Pituitary adenomas result of a multistep process in which the multi-causal and inherited genetic predisposition, endocrine factors, and specific somatic mutations are factors that may contribute to their development.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of miR-410 targeting the cyclin B1 gene plays a role in pituitary gonadotroph tumors

et al. 2015

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MicroRNAs (miRNAs) are small noncoding RNAs that act as posttranscriptional regulators of gene expression, and are frequently altered in human neoplasias. Here, we have analyzed the miRNA expression profile of human gonadotroph adenomas versus normal pituitary tissue using a miRNACHIP microarray. We demonstrate that miRNA-410 is downregulated in gonadotroph adenomas when compared with normal pituitary gland. We validate CCNB1 as target of miRNA-410 since its overexpression reduces CCNB1 at protein and mRNA levels, decreasing cell proliferation. In conclusion, our study suggess that the downregulation of miRNA-410 plays a role in the behavior of gonadotroph tumors.

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Section: Introductionmentioning

confidence: 99%

Downregulation of miR-410 targeting the cyclin B1 gene plays a role in pituitary gonadotroph tumors

et al. 2015

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“…3 A population-based study conducted in the province of Liège, Belgium, reported a 3-5 times higher prevalence of clinically relevant pituitary tumours (1:1064) than previously estimated. 4 Pituitary adenomas are generally associated with hormone overproduction and/or compression signs and symptoms due to the impingement of adjacent structures, including optic chiasm. [5][6][7][8][9][10][11] Symptoms are related to their size and position: if the adenoma is larger than 10 mm in diameter ('macroadenoma') it can extend beyond the limits of the sella and can cause neuroophthalmologic disorders by compressing the adjoining structures.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the retinal nerve fibre layer and ganglion cell complex thickness in pituitary macroadenomas without optic chiasmal compression

Cennamo

Auriemma²,

Cardone

et al. 2015

Eye

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Purpose The aim of this prospective study was to measure the thickness of the circumpapillary retinal nerve fibre layer (cpRNFL) and the ganglion cell complex (GCC) using spectral domain optical coherence tomography (SD-OCT) in a cohort of consecutive de novo patients with pituitary macroadenomas without chiasmal compression. Patients and methods Twenty-two consecutive patients with pituitary macroadenoma without chiasmal compression (16 men, 6 women, aged 45.2 ± 14.6 years, 43 eyes) entered the study between September 2011 and June 2013. Among them, 31.8% harboured a growth hormone-secreting pituitary adenoma, 27.3% a prolactin-secreting pituitary adenoma, 27.3% a corticotrophin-secreting pituitary adenoma, and 13.6% a non-secreting pituitary tumour. Eighteen subjects (nine females, nine males, mean age 36.47 ± 6.37 years; 33 eyes) without pituitary adenoma, with normal ophthalmic examination, served as controls. In both patients and controls, cpRNFL and GCC thicknesses were measured by SD-OCT. Results Patients were significantly older (P = 0.02) than controls. Best corrected visual acuity, intraocular pressure, colour fundus photography, and automatic perimetry test were within the normal range in patients and controls. Conversely, cpRNFL (P = 0.009) and GCC (Po0.0001) were significantly thinner in patients than in controls. The average GCC (r = 0.306, P = 0.046) significantly correlated with the presence of arterial hypertension. OCT parameters did not differ significantly between patients with a tumour volume above the median and those with a tumour volume below the median. Conclusion Pituitary macroadenomas, even in the absence of chiasmal compression, may induce GCC and retinal nerve fibre layer thinning. SD-OCT may have a role in the early diagnosis and management of patients with pituitary tumours.

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“…In this study only few (3/76) tumours were identified as macroadenomas corresponding to a tumour size >10 mm. (Buurman, 2006) The prevalence of clinically apparent prolactinomas ranges from 6-50/ 100,000 in reported populations (Daly, 2006;Fernandez 2010). The prevalence of "ever-treated" hyperprolactinemia is approximately 20 /100,000 in male patients and approximately 90 /100,000 in female patients.…”

Section: Characteristics Of Pituitary Adenomasmentioning

confidence: 99%

Prolactin and Infertility

Öner¹

2013

Prolactin

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High Prevalence of Pituitary Adenomas: A Cross-Sectional Study in the Province of Liège, Belgium

Abstract: The prevalence of pituitary adenomas in the study population (one case in 1064 individuals) was more than 3.5-5 times that previously reported. This increased prevalence may have important implications when prioritizing funding for research and treatment of pituitary adenomas.

Cited by 907 publications

References 14 publications

Downregulation of miR-410 targeting the cyclin B1 gene plays a role in pituitary gonadotroph tumors

Downregulation of miR-410 targeting the cyclin B1 gene plays a role in pituitary gonadotroph tumors

Evaluation of the retinal nerve fibre layer and ganglion cell complex thickness in pituitary macroadenomas without optic chiasmal compression

Prolactin and Infertility

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