High prevalence of periodic limb movements of sleep in children with Down syndrome

Rosen, Dennis; Berbert, Laura; Weller, Edie

doi:10.5664/jcsm.8202

Cited by 6 publications

(9 citation statements)

References 20 publications

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Section: Agementioning

confidence: 99%

“…Four studies evaluated the relationship between age and oAHI [8,29,33,36]. ROSEN et al [33] identified a positive association between median age and presence of OSA when comparing patients without OSA to those with mild or moderate OSA. WATERS et al [36] dichotomised children into <2 years or ⩾2 years and reported a negative relationship between age and presence and severity of OSA.…”

Section: Agementioning

confidence: 99%

“…ANAND, 2021 [16] AUSTENG, 2014 [17] BANJAR, 2013 [18] BASIL, 2016 [19] BRESLIN, 2014 [20] BROOKS, 2015 [21] CHAMSEDDIN, 2019 [22] DURHAN, 2019 [23] DYKEN, 2003 [9] ELSHARKAWI, 2017 [24] FRIEDMAN, 2018 [25] JAYARATNE, 2017 [26] LEE, 2020 [27] MARIS, 2016 [28] MARIS, 2016 [29] DE MIGUEL-DÍEZ, 2003 [4] NAIME, 2021 [30] NEHME, 2017 [8] POSADA, 2019 [31] RICHARD, 2020 [32] ROSEN, 2020 [33] SHIRES, 2010 [34] SKOTKO, 2017 [35] WATERS, 2020 [36] Bias…”

Section: Agementioning

confidence: 99%

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Predictors of sleep disordered breathing in children with Down syndrome: a systematic review and meta-analysis

Hanna

Blinder

et al. 2022

Eur Respir Rev

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Children with Down syndrome are at increased risk of sleep disordered breathing (SDB). SDB is associated with significant morbidity including neurocognitive impairment, cardiometabolic disease and systemic inflammation. The identification of clinical markers that may predict SDB is critical in facilitating early diagnosis and treatment, and ultimately, preventing morbidity. The objective of this systematic review was to identify predictors of SDB in patients with Down syndrome. A search was conducted using MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and the Cumulative Index to Nursing and Allied Health Literature. A meta-analysis was performed according to the Meta-analyses of Observational Studies in Epidemiology checklist. Our review of the literature identified inconsistent associations between a variety of variables and SDB in children with Down syndrome, although the quality of evidence was poor. Meta-analysis of age and sex identified that children with OSA were older than those without OSA, and there was a similar risk of OSA in males and females, although risk favoured males. Currently, the American Academy of Pediatrics guidelines recommend that children with Down syndrome undergo polysomnography by the age of 4 years. Our review supports the recommendation for routine screening of children with Down syndrome. However, results from our meta-analysis suggest a need for longitudinal screening to diagnose children who may develop SDB as they get older.

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Section: Agementioning

confidence: 99%

Section: Agementioning

confidence: 99%

Section: Agementioning

confidence: 99%

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Predictors of sleep disordered breathing in children with Down syndrome: a systematic review and meta-analysis

Hanna

Blinder

et al. 2022

Eur Respir Rev

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“…On the other hand, in a recent retrospective study of 418 children with DS who underwent polysomnography in a sleep center, only 13 subjects (3%) were referred due to concerns about restless leg syndrome (RLS) or periodic limb movement disorder (PLMS); 139 of the children (33.3%) presented PLMS, and 36 (55.4%) of them had ferritin levels under normal values (<50 ng/mL). PLMS causes sleep disturbances and is therefore an unnoticed factor with detrimental effects on daytime function, behavior, and cognition [ 86 ]. As in TD children, PLMS treatment with supplemental iron in children with DS and low serum ferritin levels could improve sleep quality and cognition [ 87 ].…”

Section: Sleep Disordersmentioning

confidence: 99%

Sleep Disorders in Adults with Down Syndrome

Giménez

Altuna

Blessing

et al. 2021

JCM

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Sleep disorders, despite being very frequent in adults with Down syndrome (DS), are often overlooked due to a lack of awareness by families and physicians and the absence of specific clinical sleep guidelines. Untreated sleep disorders have a negative impact on physical and mental health, behavior, and cognitive performance. Growing evidence suggests that sleep disruption may also accelerate the progression to symptomatic Alzheimer’s disease (AD) in this population. It is therefore imperative to have a better understanding of the sleep disorders associated with DS in order to treat them, and in doing so, improve cognition and quality of life, and prevent related comorbidities. This paper reviews the current knowledge of the main sleep disorders in adults with DS, including evaluation and management. It highlights the existing gaps in knowledge and discusses future directions to achieve earlier diagnosis and better treatment of sleep disorders most frequently found in this population.

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“…Common sleep problems include bedtime resistance, sleep anxiety, night waking, parasomnia, daytime sleepiness, and periodic limb movements. 1,[13][14][15][16] These problems place a significant burden on caregivers as well as impacting on their own sleep quality. The pressures of raising a child with intellectual disability often influence parenting strategies, including the ability to cope with their child's sleep problems.…”

Section: Introductionmentioning

confidence: 99%

The impact of sleep problems on functional and cognitive outcomes in children with Down syndrome: a review of the literature

Chawla

Burgess

Heussler

2020

Journal of Clinical Sleep Medicine

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The aim of this review was to summarize the existing literature on the association between sleep problems and cognition, function, and behavior in children with Down syndrome. Methods: Embase, PubMed, CINAHL, and PsychINFO databases were searched to retrieve all studies published between 1990 and 2018 that evaluated the relationship between sleep and cognition, function, or behavior in children with Down syndrome. Results: Fifteen articles were included, which were mostly of a cohort or case-controlled design. Five articles addressed sleep and cognition only, 6 reported on sleep and behavior, and only 1 reported on sleep and functional ability. Three papers evaluated sleep and both cognition and behavior. Findings varied across studies with methodological differences, making it difficult to directly compare results. The association between sleep and behavior or cognition in children with Down syndrome remains uncertain, but a large study in 110 children provides strong evidence of a negative impact of sleep disorders on the accomplishment of daily life habits. Conclusions: The impact of coexisting sleep disorders in children with Down syndrome has not been widely studied, with only 15 relevant studies found through an extensive literature review. Large well-designed studies are required to fully understand this relationship further. This is important as sleep-disordered breathing and difficulties with sleep patterns and routines are highly prevalent in children with Down syndrome. Sleep may be one of the few treatable factors that can assist in improving long-term outcomes in this population.

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High prevalence of periodic limb movements of sleep in children with Down syndrome

Cited by 6 publications

References 20 publications

Predictors of sleep disordered breathing in children with Down syndrome: a systematic review and meta-analysis

Predictors of sleep disordered breathing in children with Down syndrome: a systematic review and meta-analysis

Sleep Disorders in Adults with Down Syndrome

The impact of sleep problems on functional and cognitive outcomes in children with Down syndrome: a review of the literature

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