High prevalence of occult hepatitis C virus infection in patients with primary and secondary glomerular nephropathies

Castillo, Inmaculada; Martínez-Ara, Jorge; Olea, Teresa; Bartolomé, Javier; Madero, Rosário; Hernández, Eduardo; Bernis, Carmen; Aguilar, Ana; Quiroga, Juan Antonio; Carréño, Vicente; Selgas, Rafael

doi:10.1038/ki.2014.68

Cited by 41 publications

(40 citation statements)

References 39 publications

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“…It is noted that OCI has been detected among various patient groups worldwide; for instance, in participants with cryptogenic liver disease [Castillo et al, ; Bokharaei‐Salim et al, ], in at‐risk individuals for HCV infection such as haemodialysis patients [Barril et al, ; Thongsawat et al, ] and haemophilic individuals [Parodi et al, ], in patients with lymphoproliferative disorders [Youssef et al, ; Farahani et al, ], in kidney transplant patients [Baid‐Agrawal et al, ], in candidates for liver transplant with cryptogenic cirrhosis [Keyvani et al, ], in patients with primary and secondary glomerular nephropathies [Castillo et al, ], in patients with active HBV infection [De Marco et al, ], in HIV‐infected individuals [Gatserelia et al, ], and also in general population [De Marco et al, , ]. Of course, there are some reports where researchers have found no signs of this infection for example, in kidney transplant patients [Nicot et al, ], in mixed cryoglobulinemia [Giannini et al, ], in autoimmune disorders [Welker and Zeuzem, ], in patients experiencing an immunodepression condition [Pisaturo et al, ], and in non‐Hodgkin lymphoma [Richiardi et al, ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of occult hepatitis C virus infection in the Iranian patients with human immunodeficiency virus infection

et al. 2016

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Occult hepatitis C virus (HCV) infection is a new form of chronic HCV infection described by the presence of the genomic HCV-RNA in liver biopsy and/or peripheral blood mononuclear cell (PBMC) samples, and undetectable levels or absence of HCV-RNA and in the absence or presence of anti HCV antibodies in the plasma specimens. The aim of the present study was to evaluate the occurrence of occult HCV infection (OCI) among Iranian subjects infected with human immunodeficiency virus (HIV) using RT-nested PCR. From March 2014 until April 2015, 109 Iranian patients with established HIV infection were enrolled in this cross-sectional study. After extraction of viral RNA from the plasma and PBMC samples, HCV-RNA status was examined by RT-nested PCR using primers from the 5'-NTR. HCV genotyping was conducted using RFLP analysis. For the confirmation of HCV genotyping by RFLP method, the PCR products were sequenced. Of the 109 patients, 50 were positive for antibodies against HCV. The HCV-RNA was detected in PBMC specimens in 6 (10.2%) out of the total 59 patients negative for anti-HCV Abs and undetectable plasma HCV-RNA and also from 4 (8.0%) out of the total 50 patients positive for anti-HCV Abs and undetectable plasma HCV-RNA. HCV genotyping analysis showed that 6 (60.0%) patients were infected with HCV subtype 3a, 3 (30.0%) were infected with HCV subtype 1a and 1 (10.0%) patient was infected with HCV subtype 1b. This study revealed the incidence of OCI (9.2%) in HIV-infected Iranian patients. Hence, designing prospective studies focusing on the detection of OCI in these patients would provide more information. J. Med. Virol. 88:1960-1966, 2016. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Prevalence of occult hepatitis C virus infection in the Iranian patients with human immunodeficiency virus infection

et al. 2016

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“…82 A high frequency of occult HCV infection was identified among patients with glomerular disease who tested negative for anti HCV antibodies and RNA, and who had not undergone kidney transplantation. 83,84 The impact of this finding remains to be determined in renal transplant recipients.…”

Section: Renal Disease Induced By Hcv Infectionmentioning

confidence: 99%

Hepatitis C and its impact on renal transplantation

Morales

Fabrizi

2015

Nat Rev Nephrol

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Infection with hepatitis C virus (HCV) is the major cause of chronic liver disease that occurs after renal transplantation. Such infection is often acquired during dialysis while patients wait to undergo renal transplantation. Renal transplantation is considered the best treatment option for patients with HCV infection and end-stage renal disease, although acceptance of a kidney graft by the host immune system and patient survival are lower compared to patients who test negative for HCV. The approval of interferon-free therapies could substantially change the natural history of HCV infection after renal transplantation. This Review discusses the interplay between renal transplantation, HCV infection, and liver disease. We emphasize the development of novel therapeutic strategies, including use of the newly identified direct-acting antiviral agents for treating hepatitis C among infected patients. We next analyse the most common clinical complications subsequent to HCV infection and the impact on graft and patient survival. Finally, we evaluate the consequences of kidney transplantation from HCV-positive donors.

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“…OCI, as a state of nonapparent but real HCV infection, could explain these differences between HCV infection and T2DM. Furthermore, our group has demonstrated an association between OCI and a large spectrum of immune-mediated glomerular diseases, including a role in the progression of the disease [14].…”

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confidence: 94%

Occult Hepatitis C Virus Infection in Patients with Diabetic Nephropathy: Epidemiological and Clinical Implications

Olea¹,

Castillo²,

González³

et al. 2017

World Journal of Research and Review

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Background:A high prevalence of hepatitis C virus (HCV) infection in patients with diabetic kidney disease (DKD) has been reported. However, the epidemiology and relationship between DKD and occult HCV infection (OCI)are unknown.Objetives: To determine the prevalence of OCI in a population without conventional markers of HCV infection diagnosed with DKD, and to study its possible clinical implications.Study design: This prospective study included 125 anti-HCV and serum HCV-RNA-negative patients with DKD for the presence of OCI. HCV-RNA was tested by real-time reverse transcription PCR in peripheral blood mononuclear cells and in plasma after ultracentrifugation. Results: OCI was positive in 10 patients (8%). The patients with OCI had significantly higher ferritin levels (p=.002) and monoclonal gammopathy (30% [3/10] vs. 0.87% [1/115] than the patients without OCI [p=.003]). We found similar plasma ALT and GGT levels and HbA1C in both groups. At the end of the follow-up, the progression rate of renal disease tended to be faster in the group with OCI relative to the negative one, but without a significant difference. We did not find an association between OCI and cardiovascular morbidity. Conclusions: There was an 8% prevalence of OCI in patients with chronic renal failure secondary to DKD, higher than in the general population. This occult infection does not appear to play a role in the control of diabetes, cardiovascular risk or steatosis. However, the progression rate of renal disease tended to be faster, and the incidence of associated monoclonal gammopathy was significant. Index Terms-Diabetes Kidney Disease, Type 2 diabetes mellitus, Occult hepatitis C virus. I. INTRODUCTION Type 2 diabetes mellitus (T2DM) and hepatitis C virus

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High prevalence of occult hepatitis C virus infection in patients with primary and secondary glomerular nephropathies

Cited by 41 publications

References 39 publications

Prevalence of occult hepatitis C virus infection in the Iranian patients with human immunodeficiency virus infection

Prevalence of occult hepatitis C virus infection in the Iranian patients with human immunodeficiency virus infection

Hepatitis C and its impact on renal transplantation

Occult Hepatitis C Virus Infection in Patients with Diabetic Nephropathy: Epidemiological and Clinical Implications

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