High prevalence of Mycoplasma infections among European chronic fatigue syndrome patients. Examination of four Mycoplasma species in blood of chronic fatigue syndrome patients

Nijs, Jan

doi:10.1016/s0928-8244(02)00398-x

Cited by 27 publications

(40 citation statements)

References 10 publications

(13 reference statements)

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“…pneumoniae infects the upper and lower respiratory tracts in children and adults and is one of the aetiological agents of community-acquired pneumonia [11,12]. Studies have shown that it can cause up to 40% of community-acquired pneumonia and 18% of hospitalisations in children [13].…”

Section: Disease Background Informationmentioning

confidence: 99%

Surveillance status and recent data for Mycoplasma pneumoniae infections in the European Union and European Economic Area, January 2012

et al. 2012

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In January 2012, the European Centre for Disease Prevention and Control (ECDC) conducted an email-based survey of European Union and European Economic Area countries to describe the existing surveillance activities for Mycoplasma pneumoniae infections, recent findings and existence of clinical guidelines for the treatment of M. pneumoniae infection. Of the 20 countries that participated in the survey, seven reported increases in M. pneumoniae infections observed during the autumn and winter of 2011.

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Section: Disease Background Informationmentioning

confidence: 99%

Surveillance status and recent data for Mycoplasma pneumoniae infections in the European Union and European Economic Area, January 2012

et al. 2012

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“…Similarly, Vojdani et al also found Mycoplasma species in a majority of CFS/ME patients [200], but this has not been seen in all studies [202]. Regional differences may be important, because when European CFS patients were examined for various Mycoplasma species, the most common species found was M. hominis [203], whereas in North America the most common species found was M. pneumoniae [197,201].…”

Section: Chronic Fatigue Syndrome (Cfs)mentioning

confidence: 95%

Neurodegenerative and Fatiguing Illnesses, Infections and Mitochondrial Dysfunction: Use of Natural Supplements to Improve Mitochondrial Function.

Nicolson

Settineri

Ellithorpe³

2014

FFHD

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Background: Many chronic diseases and illnesses are associated with one or more chronic infections, dysfunction of mitochondria and reduced production of ATP. This results in fatigue and other symptoms that occur in most if not all chronic conditions and diseases.Methods: This is a review of the published literature on chronic infections in neurodegenerative diseases and fatiguing illnesses that are also typified by mitochondrial dysfunction. This contribution also reviews the use of natural supplements to enhance mitochondrial function and reduce the effects of chronic infections to improve overall function in various chronic illnesses.Results: Mitochondrial function can be enhanced by the use of various natural supplements, notably Lipid Replacement Therapy (LRT) using glyerolphospholipids and other mitochondrial supplements. In various chronic illnesses that are characterized by the presence of chronic infections, such as intracellular bacteria (Mycoplasma, Borrelia, Chlamydia and other infections) and viruses, LRT has proven useful in multiple clinical trials. For example, in clinical studies on chronic fatigue syndrome, fibromyalgia syndrome and other chronic fatiguing illnesses where a large majority of patients have chronic infections, LRT significantly reduced fatigue by 35-43% in different clinical trials and increased mitochondrial function. In clinical trials on patients with multiple intracellular bacterial infections and intractable fatigue LRT plus other mitochondrial supplements significantly decreased fatigue and improved mood and cognition.Conclusions: LRT formulations designed to improve mitochondrial function appear to be useful as non-toxic dietary supplements for reducing fatigue and restoring mitochondrial and other cellular membrane functions in patients with chronic illnesses and multiple chronic infections. BackgroundPatients with chronic neurodegenerative, neurobehavioral and fatiguing illnesses commonly test positive for systemic and central nervous system (CNS) bacterial and viral infections [1][2][3]. In addition, other chronic illnesses where neurological manifestations are routinely found, such as autoimmune diseases and other chronic illnesses and disorders, also show evidence of systemic bacterial and viral infections that could be important in disease inception, progression and/or enhancing the types and severities of signs and symptoms [2,3].Evidence of bacterial infections, such as Mycoplasma species, Chlamydia pneumoniae, Borrelia burgdorferi, among others, and viruses, such as human herpesvirus (HHV), cytomegalovirus (CMV), human herpes viruses (HHV) and other viral infections, have revealed high rates of infection in the illnesses listed above that were not found in control populations [1][2][3]. Although the specific roles of chronic infections in various diseases and their pathogeneses have not been carefully determined, the data suggest that chronic bacterial and/or viral infections are common features of essentially all progressive chronic diseases [1][2][3].An...

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“…Among healthy individuals, some species of Mycoplasma are part of the normal human flora present on the surface of the oral, gastric or urogenital mucosa, and when certain species of Mycoplasma invade tissues, blood and organs, they are capable of inducing a complex systemic infection (33).…”

Section: Is Lyme Disease-like Syndrome a New Tick-borne Disease?mentioning

confidence: 99%

“…Recently, Eskow et al (37) Other studies have shown that a high proportion of patients with chronic fatigue present infection by at least one species of Mycoplasma: M. hominis, M. pneumoniae and M. fermentans (28,33). It was also reported that patients with chronic fatigue demonstrated evidence of infection by C. pneumoniae and active human herpes virus-6 (28).…”

Section: Is Lyme Disease-like Syndrome a New Tick-borne Disease?mentioning

confidence: 99%

Description of Lyme disease-like syndrome in Brazil: is it a new tick borne disease or Lyme disease variation?

Mantovani

Costa²,

Gauditano

et al. 2007

Braz J Med Biol Res

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An emerging clinical entity that reproduces clinical manifestations similar to those observed in Lyme disease (LD) has been recently under discussion in Brazil. Due to etiological and laboratory particularities it is named LD-like syndrome or LD imitator syndrome. The condition is considered to be a zoonosis transmitted by ticks of the genus Amblyomma, possibly caused by interaction of multiple fastidious microorganisms originating a protean clinical picture, including neurological, osteoarticular and erythema migrans-like lesions. When peripheral blood of patients with LD-like syndrome is viewed under a dark-field microscope, mobile uncultivable spirochete-like bacteria are observed. PCR carried out with specific or conservative primers to recognize Borrelia burgdorferi sensu stricto or the genus Borrelia has been negative in ticks and in biological samples. Two different procedures, respectively involving hematoxylin and eosin staining of cerebrospinal fluid and electron microscopy analysis of blood, have revealed spirochetes not belonging to the genera Borrelia, Leptospira or Treponema. Surprisingly, co-infection with microorganisms resembling Mycoplasma and Chlamydia was observed on one occasion by electron microscopy analysis. We discuss here the possible existence of a new tick-borne disease in Brazil imitating LD, except for a higher frequency of recurrence episodes observed along prolonged clinical follow-up.

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High prevalence of Mycoplasma infections among European chronic fatigue syndrome patients. Examination of four Mycoplasma species in blood of chronic fatigue syndrome patients

Cited by 27 publications

References 10 publications

Surveillance status and recent data for Mycoplasma pneumoniae infections in the European Union and European Economic Area, January 2012

Surveillance status and recent data for Mycoplasma pneumoniae infections in the European Union and European Economic Area, January 2012

Neurodegenerative and Fatiguing Illnesses, Infections and Mitochondrial Dysfunction: Use of Natural Supplements to Improve Mitochondrial Function.

Description of Lyme disease-like syndrome in Brazil: is it a new tick borne disease or Lyme disease variation?

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