High prevalence of methicillin resistant and enterotoxin gene-positive Staphylococcus aureus among nasally colonized food handlers in central Iran

Fooladvand, Saeed; Sarmadian, Hossein; Habibi, Danial; Belkum, Alex van; Ghaznavi‐Rad, Ehsanollah

doi:10.1007/s10096-018-3398-0

Cited by 23 publications

(24 citation statements)

References 34 publications

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“…Our patients displayed a similar nasal carriage rate for S. aureus (28.7%) as previously reported for the population of central Iran (22.1% [9] and 20.1% [10]). The MRSA nasal colonization rate (27.7%) was higher than reported for institutes in the USA [11], China [12], and Turkey [13], though lower than the 46% recorded in Brazil [14].…”

Section: Carriage and Infectionsupporting

confidence: 88%

Elimination of Staphylococcus aureus nasal carriage in intensive care patients lowers infection rates

Danesh

nejad

Sarmadian

et al. 2019

Eur J Clin Microbiol Infect Dis

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This study surveys the clinical relevance of the nasal Staphylococcus aureus colonization status on intensive care unit (ICU)acquired S. aureus infections and compares molecular characteristics of isolates from the nose and infectious sites. The 390 patients included comprised 278 non-carriers and 112 carriers. Among the carriers, 56 were decolonized with mupirocin. Decolonization was verified through a second (negative) culture. Spa typing and virulence gene profiling were performed for all isolates. Twenty six S. aureus infections were detected in the carriage group and 20 in the non-carriage group. Eighteen of these 26 (69.2%) infections were among carriers, and 8 of these 26 (30.8%) infections occurred among decolonized carriers (p = 0.02). Overall, 31/112 (27.7%) of the colonized patients and 25/46 (60.1%) of infection were due to methicillin-resistant S. aureus (MRSA). The highest frequency virulence genes were sea and hlg (both 100%) in nasal isolates and sea, hlg, fnb, and clf (100%) for infectious isolates. t030 was the most abundant spa type overall. S. aureus carriers were more likely to develop S. aureus infection compared with decolonized and non-carrying patients. The sources of ICU S. aureus infection appear to be exogenous mostly, and a predominant clone (spa type 030) plays an important role. We confirm that nasal mupirocin treatment prevents ICU infections even when there is an increased prevalence of nosocomial MRSA.

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Section: Carriage and Infectionsupporting

confidence: 88%

Elimination of Staphylococcus aureus nasal carriage in intensive care patients lowers infection rates

Danesh

nejad

Sarmadian

et al. 2019

Eur J Clin Microbiol Infect Dis

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“…Methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative staphylococci (MRCoNS) represent main causes of hospital-and community-acquired infections; because of their increasing numbers and elevated mortality, morbidity, and medical expenses, they have become a global concern in recent years [1,2]. Staphylococci contain virulence factors and toxins that cause various diseases including blood, skin and soft tissues infections, nosocomial infections connected with the presence of medical devices, and toxic shock syndrome [3].…”

Section: Introductionmentioning

confidence: 99%

The global prevalence of Daptomycin, Tigecycline, Quinupristin/Dalfopristin, and Linezolid-resistant Staphylococcus aureus and coagulase–negative staphylococci strains: a systematic review and meta-analysis

Shariati

Dadashi

Chegini

et al. 2020

Antimicrob Resist Infect Control

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“…The present study showed that a combination of more than one enterotoxin gene was found in 9.6% of S. aureus isolates. The most frequent gene combination was SEA with SEC (4.3%), similarly Fooladvand et al, 2019 [24] detected 40.8%,14.7%, and 1.9% combination of two, three, or four SEs genes, respectively. Also, Udo et al, 2009 [16] demonstrated that 38%, 20%, and 7% of S. aureus isolates contained two, three, and four SE genes respectively.…”

Section: Discussionmentioning

confidence: 53%

“…The MRSA strains in the present study demonstrated a higher prevalence (61.5%) of SE genes which is significantly higher than MSSA (14.8%) (P < 0.05). This may be due to the possible handling of contaminated food and multiple infection with SFP among food handlers [24]. The present study showed that a combination of more than one enterotoxin gene was found in 9.6% of S. aureus isolates.…”

Section: Discussionmentioning

confidence: 54%

Prevalence of Methicillin-Resistant Staphylococcus aureus and Classical Enterotoxin Genes Among Sudanese Food Handlers

Ahmed

2020

Cureus

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Food handlers who carry enterotoxin-producing Staphylococcus aureus could become potential reservoirs of Staphylococcal food poisoning. The study is a cross-sectional one aimed to determine the prevalence of methicillin-resistant S. aureus (MRSA) and staphylococcal enterotoxins from randomly selected food handlers in Al Jazirah state, Sudan. Culture swabs were collected from the hands and nasals of food handlers (2016-2018). Identification of S. aureus was done on the basis of conventional laboratory tests. All S. aureus isolates were screened for MRSA and staphylococcal enterotoxin (SE) genes by polymerase chain reaction. The S. aureus strains were isolated from 25% of the collected culture swabs of which 42% were confirmed as MRSA. The existence of one or more of enterotoxin genes was confirmed in 34.4% of the isolated S. aureus strains. The combined staphylococcal enterotoxin genes were found in 9.6% of the isolates. The SE genes among MRSA strains (61.5%) were found to be higher than methicillin-sensitive S. aureus strains (14.8%). The most frequent staphylococcal enterotoxin genes were SEA (19.4%) followed by the SEB (8.6%), SEC (4.3%), and SED (2.1%). The carriage rate of MRSA strains demonstrated a higher rate of staphylococcal enterotoxins genes than methicillin-sensitive S. aureus . There is an increasing prevalence of MRSA compared with the previous rates and staphylococcal enterotoxin genes among Sudanese food handlers, which is a serious problem for public health.

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High prevalence of methicillin resistant and enterotoxin gene-positive Staphylococcus aureus among nasally colonized food handlers in central Iran

Cited by 23 publications

References 34 publications

Elimination of Staphylococcus aureus nasal carriage in intensive care patients lowers infection rates

Elimination of Staphylococcus aureus nasal carriage in intensive care patients lowers infection rates

The global prevalence of Daptomycin, Tigecycline, Quinupristin/Dalfopristin, and Linezolid-resistant Staphylococcus aureus and coagulase–negative staphylococci strains: a systematic review and meta-analysis

Prevalence of Methicillin-Resistant Staphylococcus aureus and Classical Enterotoxin Genes Among Sudanese Food Handlers

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