High Prevalence of Metabolic Syndrome in Young Hispanic Women: Findings from the National Sister to Sister Campaign

Rodríguez, Fátima; Naderi, Sahar; Wang, Yun; Johnson, Caitlin E.; Foody, JoAnne M.

doi:10.1089/met.2012.0109

Cited by 9 publications

(7 citation statements)

References 22 publications

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“…Patients with HCC are at risk for complications and mortality from cirrhosis, HCC, and other comorbidities. Consistent with prior studies, we found that Hispanic patients had higher rates of comorbidities including metabolic syndrome[19,20] and ESRD[21-23]. Our data builds on existing literature by showing that these differences persist in patients with HCC.…”

Section: Discussionsupporting

confidence: 90%

Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites

Venepalli

Modayil

Berg

et al. 2017

WJH

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AIMTo compare features of hepatocellular carcinoma (HCC) in Hispanics to those of African Americans and Whites.METHODSPatients treated for HCC at an urban tertiary medical center from 2005 to 2011 were identified from a tumor registry. Data were collected retrospectively, including demographics, comorbidities, liver disease characteristics, tumor parameters, treatment, and survival (OS) outcomes. OS analyses were performed using Kaplan-Meier method.RESULTSOne hundred and ninety-five patients with HCC were identified: 80.5% were male, and 22% were age 65 or older. Mean age at HCC diagnosis was 59.7 ± 9.8 years. Sixty-one point five percent of patients had Medicare or Medicaid; 4.1% were uninsured. Compared to African American (31.2%) and White (46.2%) patients, Hispanic patients (22.6%) were more likely to have diabetes (P = 0.0019), hyperlipidemia (P = 0.0001), nonalcoholic steatohepatitis (NASH) (P = 0.0021), end stage renal disease (P = 0.0057), and less likely to have hepatitis C virus (P < 0.0001) or a smoking history (P < 0.0001). Compared to African Americans, Hispanics were more likely to meet criteria for metabolic syndrome (P = 0.0491), had higher median MELD scores (P = 0.0159), ascites (P = 0.008), and encephalopathy (P = 0.0087). Hispanic patients with HCC had shorter OS than the other racial groups (P = 0.020), despite similarities in HCC parameters and treatment.CONCLUSIONIn conclusion, Hispanic patients with HCC have higher incidence of modifiable metabolic risk factors including NASH, and shorter OS than African American and White patients.

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Section: Discussionsupporting

confidence: 90%

Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites

Venepalli

Modayil

Berg

et al. 2017

WJH

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“…MAP3K9 was most strongly associated among women with the highest IA ancestry and multiple SNPs in this gene interacted with a history of diabetes to alter risk of breast cancer. At a population level, rates of diabetes and metabolic syndrome are higher among Hispanic, Native American and Mexican women than among NHW women [45–47]. While assessment of interaction of diet and lifestyle factors within ancestry groups would be desirable, our power was limited to meaningfully evaluate these 3-way interactions.…”

Section: Discussionmentioning

confidence: 99%

MAPK Genes Interact with Diet and Lifestyle Factors to Alter Risk of Breast Cancer: The Breast Cancer Health Disparities Study

Slattery

Lundgreen

John

et al. 2015

Nutrition and Cancer

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Mitogen-activated protein kinases (MAPK) are integration points for multiple biochemical signals. We evaluated 13 MAPK genes with breast cancer risk and determined if diet and lifestyle factors mediated risk. Data from three population-based case-control studies conducted in Southwestern United States, California, and Mexico included 4183 controls and 3592 cases. Percent Indigenous American (IA) ancestry was determined from 104 Ancestry Informative Markers. The adaptive rank truncated product (ARTP) was used to determine the significance of each gene and the pathway with breast cancer risk, by menopausal status, genetic ancestry level, and ER/PR strata. MAP3K9 was associated with breast cancer overall (PARTP=0.02) with strongest association among women with the highest IA ancestry (PARTP=0.04). Several SNPs in MAP3K9 were associated with ER+/PR+ tumors and interacted with dietary oxidative balance score (DOBS), dietary folate, body mass index (BMI), alcohol consumption, cigarette smoking, and a history of diabetes. DUSP4 and MAPK8 interacted with calories to alter breast cancer risk; MAPK1 interacted with DOBS, dietary fiber, folate and BMI; MAP3K2 interacted with dietary fat; and MAPK14 interacted with dietary folate and BMI. The patterns of association across diet and lifestyle factors with similar biological properties for the same SNPs within genes provide support for associations.

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“…Different populations have different risk to MA and MS. INTERHEART and INTERSTROKE studies demonstrated that abdominal obesity (AO) in Latin American countries was the highest cardiovascular risk factor compared with the rest of the world (Lanas et al, ; O'Donnell et al, ). Studies conducted in the United States show a higher prevalence of MA and MS in the general Latino population, with figures showing around a 50%‐60% higher risk of MS (Daviglus et al, ; Rodriguez, Naderi, Wang, Johnson, & Foody, ; Roger et al, ). Echoing these results, studies in psychotic patients show that Latino patients have a significantly higher prevalence of MS than non‐Latino ones (Kato, Currier, Gomez, Hall, & Gonzalez‐Blanco, ).…”

Section: Introductionmentioning

confidence: 99%

“…Despite different studies have shown that antipsychotic-naïve first-episode psychosis patients do not differ in their baseline rates of MS in comparison with healthy subjects (Fleischhacker et al, 2013;Mitchell, Vancampfort, Sweers, et al, 2013), they rapidly add more metabolic risk factors during the first year of treatment (Curtis et al, 2011 (AO) in Latin American countries was the highest cardiovascular risk factor compared with the rest of the world (Lanas et al, 2007;O'Donnell et al, 2010). Studies conducted in the United States show a higher prevalence of MA and MS in the general Latino population, with figures showing around a 50%-60% higher risk of MS (Daviglus et al, 2012;Rodriguez, Naderi, Wang, Johnson, & Foody, 2013;Roger et al, 2011). Echoing these results, studies in psychotic patients show that Latino patients have a significantly higher prevalence of MS than non-Latino ones (Kato, Currier, Gomez, Hall, & Gonzalez-Blanco, 2004).…”

Section: Introductionmentioning

confidence: 99%

High prevalence of metabolic alterations in Latin American patients at initial stages of psychosis

Iruretagoyena

Castañeda²,

Undurraga

et al. 2019

Early Intervention Psych

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Aim Studies conducted in the United States have highlighted a higher prevalence of metabolic alterations (MA) in Latino population and Latino psychotic patients. Metabolic risk in psychosis is known to be present from initial stages of the disease. To better characterize this population, we explored the prevalence of MA and metabolic syndrome (MS) in early psychosis patients in a Latin American country. Methods Transversal, observational study comparing the prevalence of MA and MS in patients with early psychosis from an outpatient program in Chile (n = 148) with a community representative sample from the 2009‐2010 National Health Survey (n = 568). ANOVA and regression analysis were performed obtaining odds ratio for MA and MS. Results The prevalence of MS was 44.7% in patients compared to 11.4% in the community sample (odds ratio [OR] 5.28, confidence interval [CI] 95% 3.07‐9.08; P‐value <0.001). There was no effect of gender. Subgroup analyses showed no significant association of MS with clozapine/olanzapine use, treatment duration or tobacco use. There was an association between treatment duration and hypertriglyceridemia (P = 0.024; OR 1.02, CI 95% 1.00‐1.04) and obesity (P = 0.007; OR 5.93, CI 95% 1.82‐20.22). Clozapine/olanzapine use was associated with hyperglycaemia (P = 0.007; OR 6.04, CI 95% 1.63‐22.38) and high low density lipoprotein (P = 0.033 ANOVA; OR 5.28, CI 95% 1.14‐24.37). Conclusion Latino psychotic patients have a high risk of MA and MS at initial stages of the disease which is not entirely explained by the higher risk in the whole Latino population, is irrespective of gender, and does not seem to be entirely a response to atypical antipsychotic use.

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High Prevalence of Metabolic Syndrome in Young Hispanic Women: Findings from the National Sister to Sister Campaign

Cited by 9 publications

References 22 publications

Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites

Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites

MAPK Genes Interact with Diet and Lifestyle Factors to Alter Risk of Breast Cancer: The Breast Cancer Health Disparities Study

High prevalence of metabolic alterations in Latin American patients at initial stages of psychosis

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