High prevalence of luminal B breast cancer intrinsic subtype in Colombian women

Serrano-Gómez, Silvia J.; Sanabria‐Salas, María Carolina; Hernández-Suárez, Gustavo; Garcı́a, Oscar; Silva, Camilo; Romero, Alejandro; Mejía, Juan Carlos; Miele, Lucio; Fejerman, Laura; Zabaleta, Jovanny

doi:10.1093/carcin/bgw043

Cited by 44 publications

(43 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Luminal A-like disease with good prognosis is seen only is 18.3% of the cases which is in contrast to the figures from other areas reported to be 27.1% by Smriti Tiwari et al, 51.6% by Ahoua B Effect et al, Lin Ch 67% and it has been reported to be as high as 74.3% by Ahmed Abdel-Latif [10][11][12][13][14]. Luminal B like was the commonest type seen in our patients, like in Columbian women which were 37.2% [15]. Triple negative comprised of 25.7% of the cases, in some studiesit was reported to be much higher in African andas high as 82.2% [16][17][18].…”

Section: Discussioncontrasting

confidence: 79%

Prevalence of Breast Cancer Intrinsic Subtypes and Its Association with Clinico-Pathological Feature

2018

ABBSR

View full text Add to dashboard Cite

Breast cancer is the commonest cancer in women worldwide and represents a highly heterogeneous group of tumours particularly in terms of molecular features, prognosis and response to therapy.Breast cancer molecular classification can predict the prognosis of breast cancer in terms of recurrence and help and guide us regarding the treatment decision about systemic therapy. Breast carcinomas may be stratified into subtypes similar to those defined by Gene expression profiling using a panel of immune-histochemical (IHC) markers. Routine IHC evaluations of breast cancers may, therefore, provide a reasonable alternative to costly genetic assays especially in under-resourced healthcare systems. The purpose of this study is to investigate the prevalence of molecular subtypes and correlate it to clinic-pathological features.Methods: From 2005 to 2017 total of 4847 Breast cancer patients, in whom complete information was available to classify them into luminal subtypes were retrieved and classified into intrinsic subtypes and patients information in each type was collected about age, tumour size, stage, grade and nodal status. Results:In luminal classification, a highly significant difference was found in mean age (p<0.001) tumour size (p<0.001), grade, metastasis and Ki67. The statistical significance of Her 2 positive and triple negative was found with stage, grade, metastasis and Ki67.Conclusions: IHC assignment into Luminal subtypes is clinically informative in our patients and routinely using this in our practice could identify patients that may need a more aggressive treatment to reduce the likelihood of recurrences.

show abstract

Section: Discussioncontrasting

confidence: 79%

Prevalence of Breast Cancer Intrinsic Subtypes and Its Association with Clinico-Pathological Feature

2018

ABBSR

View full text Add to dashboard Cite

show abstract

“…There are very few studies that compare tumor subtype distribution in women from different regions within the same Latin American country [23], and no studies, to the best of our knowledge, that compare Latinas from different regions but who have similar continental genetic background. Future research should focus on the discovery of subcontinental genetic differences (e.g.…”

Section: Discussionmentioning

confidence: 99%

Breast cancer subtype and survival among Indigenous American women in Peru

et al. 2018

Self Cite

View full text Add to dashboard Cite

Latina women in the U.S. have relatively low breast cancer incidence compared to Non-Latina White (NLW) or African American women but are more likely to be diagnosed with the more aggressive “triple negative” breast cancer (TNBC). Latinos in the U.S. are a heterogeneous group originating from different countries with different cultural and ancestral backgrounds. Little is known about the distribution of tumor subtypes in Latin American regions. Clinical records of 303 female Peruvian patients, from the Peruvian National Cancer Institute, were analyzed. Participants were diagnosed with invasive breast cancer between 2010 and 2015 and were identified as residing in either the Selva or Sierra region. We used Fisher’s exact test for proportions and multivariable Cox Proportional Hazards Models to compare overall survival between regions. Women from the Selva region were more likely to be diagnosed with TNBC than women from the Sierra region (31% vs. 14%, p = 0.01). In the unadjusted Cox model, the hazard of mortality was 1.7 times higher in women from the Selva than the Sierra (p = 0.025); this survival difference appeared to be largely explained by differences in the prevalence of TNBC. Our results suggest that the distribution of breast cancer subtypes differs between highly Indigenous American women from two regions of Peru. Disentangling the factors that contribute to this difference will add valuable information to better target prevention and treatment efforts in Peru and improve our understanding of TNBC among all women. This study demonstrates the need for larger datasets of Latin American patients to address differences between Latino subpopulations and optimize targeted prevention and treatment.

show abstract

“…Multiple studies have shown that while Hispanics/Latinas (Latinas) have lower breast cancer incidence and mortality rates than non-Hispanic White women, they have a higher risk of breast cancer-specific mortality with hazard ratio (HR) estimates ranging from 1.1 to 1.3 (3)(4)(5)(6)(7). This disparity could be in part explained by the fact that Latinas are more likely to be diagnosed with the more aggressive HER2 þ and hormone receptornegative subtypes of the disease than non-Hispanic White women (8)(9)(10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer Is Associated with Indigenous American Ancestry in Latin American Women

et al. 2020

Self Cite

View full text Add to dashboard Cite

Women of Latin American origin in the United States are more likely to be diagnosed with advanced breast cancer and have a higher risk of mortality than non-Hispanic White women. Studies in U.S. Latinas and Latin American women have reported a high incidence of HER2 positive (þ) tumors; however, the factors contributing to this observation are unknown. Genomewide genotype data for 1,312 patients from the Peruvian Genetics and Genomics of Breast Cancer Study (PEGEN-BC) were used to estimate genetic ancestry. We tested the association between HER2 status and genetic ancestry using logistic and multinomial logistic regression models. Findings were replicated in 616 samples from Mexico and Colombia. Average Indigenous American (IA) ancestry differed by subtype. In multivariate models, the odds of having an HER2 þ tumor increased by a factor of 1.20 with every 10% increase in IA ancestry proportion (95% CI, 1.07-1.35; P ¼ 0.001). The association between HER2 status and IA ancestry was independently replicated in samples from Mexico and Colombia. Results suggest that the high prevalence of HER2 þ tumors in Latinas could be due in part to the presence of population-specific genetic variant(s) affecting HER2 expression in breast cancer. Significance: The positive association between Indigenous American genetic ancestry and HER2 þ breast cancer suggests that the high incidence of HER2 þ subtypes in Latinas might be due to population and subtype-specific genetic risk variants.

show abstract

High prevalence of luminal B breast cancer intrinsic subtype in Colombian women

Cited by 44 publications

References 46 publications

Prevalence of Breast Cancer Intrinsic Subtypes and Its Association with Clinico-Pathological Feature

Prevalence of Breast Cancer Intrinsic Subtypes and Its Association with Clinico-Pathological Feature

Breast cancer subtype and survival among Indigenous American women in Peru

Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer Is Associated with Indigenous American Ancestry in Latin American Women

Contact Info

Product

Resources

About