High Prevalence of Low Serum Paraoxonase-1 in Subjects with Coronary Artery Disease

Jayakumari, N.; Thejaseebai, Gopalan

doi:10.3164/jcbn.08-255

Cited by 42 publications

(46 citation statements)

References 24 publications

(28 reference statements)

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“…In the current study, PON1, ghrelin and AE activity were found to be significantly lower (p<0.05) in workers occupationally exposed to cement dust than in the control groups. This could be related to enhanced lipid peroxidation, (9) since oxidized lipids are reported to inhibit PON1 activity (34,35). Decreased PON1 and AE blood serum levels observed in the cement dust exposed subjects could also have been caused by a change in HDL secondary levels or decreased protein expression as a result of tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Ghrelin, Nitrite and Paraoxonase/Arylesterase Concentrations in Cement Plant Workers

Aydın¹,

Aydın²,

Croteau³

et al. 2010

Journal of Medical Biochemistry

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Kratak sadr`aj: Izlaganje cementnoj pra{ini na radnom mestu povezano je s pove}anim rizikom od promena na jetri, plu}nih bolesti i nastanka kancera. Mogu}i mehanizmi koji uzrokuju bolesti su smanjeni antioksidativni kapacitet i po vi{e na lipidna peroksidacija u plazmi. U skladu s tim, u ovoj studiji prou~avani su nivoi paraoksonaze (PON1) -arilesteraze (AE), grelina, HDL-C, LDL-C i nitrita (NOx) u serumu kod radnika izlo`enih cementnoj pra{ini. U studiji je u~e stvovalo dvadeset osam radnika u cementari i 30 dobro voljaca (kontrola), starosti 29-54 godine. Koncentra cije PON1, AE, NOx, grelina i HDL-holesterola i LDL-holesterola u serumu merene su u obe grupe. PON-1, AE, grelin i HDL-holesterol bili su ni`i kod radnika u cementari nego u kontrolnoj grupi. Nivoi nitrita i LDL-C u serumu kod radnika u cementari bili su vi{i (p<0,05) nego u kontrolnoj grupi radnika. Nije prime}ena korelacija izme|u nivoa HDL-holesterola i PON1 u serumu, kao ni izme|u HDL-holesterola i grelina. Slaba nega tivna korelacija otkrivena je izme|u grelina i NOx u serumu. Rezultati studije sna`no ukazuju na to da HDL-paraoksonaza, AE, grelin, HDL-C i visoki nivoi NOx i LDL-C verovatno igraju ulogu u bolesti koja uklju~uje oksidativna o{te}enja. Me|utim, potrebna su dalja istra`ivanja kako bi se ispitala veza izme|u izlaganja pra{ini na radnom mestu i respiratornih simptoma.

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Section: Discussionmentioning

confidence: 99%

Ghrelin, Nitrite and Paraoxonase/Arylesterase Concentrations in Cement Plant Workers

Aydın¹,

Aydın²,

Croteau³

et al. 2010

Journal of Medical Biochemistry

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“…PON1, an antioxidant enzyme, circulates in the blood and is associated with HDL particle, and can destroy lipids in the form of oxidised low-density lipoproteins (Sahin et al 2004). Jayakumari and Gopalan (2009) observed that low serum PON1 activity is correlated with low serum vitamin C, suggesting that PON1 level is positively correlated with the anti-oxidant level. Jarvik et al (2002) reported that vitamin C is a positive predictor of PON1, and its level increases with anti-oxidant vitamins.…”

Section: Discussionmentioning

confidence: 80%

Serum antioxidants and trace minerals as influenced by vitamins, probiotics and proteins in broiler breeders

Khan

Zia-ur-Rahman

Javed

et al. 2014

Journal of Applied Animal Research

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One hundred and eighty birds at the age of 65 weeks were induced to moult by mixing zinc oxide in their feed at the rate 3000 mg/kg of feed. Upon completion of moulting, the birds were divided into six groups (five replicates) by a completely randomised design. One group was kept as control (16% crude protein [CP]) while the other five were supplemented with vitamin E (100 IU/kg feed), vitamin C (500 IU/kg feed), probiotics (50 mg/L), protein level (14% CP) and their combination. At the end of the experiment, the results revealed that serum total antioxidant response significantly increased in the vitamin E fed group compared to the other treated groups. Paraoxonase and arylesterase were significantly higher in vitamin E and C groups. The ceruloplasmin level decreased significantly in the vitamin C fed group as well as in the group having the combination of all the treatments. The homocysteine was significantly lower in the vitamin E fed group compared to the other treated groups. In trace elements, serum zinc was significantly high in vitamin E supplemented group. These findings suggested that compared to other treatments, vitamin E has pronounced influence on improving the anti-oxidant status in male broiler breeders.

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“…There is not enough clinical data to support this concept of functional deficiency in HDL as a contributing factor for the increased prevalence of CHD. Earlier study from this laboratory revealed that serum levels of HDL-C and paraoxonase-1, an antioxidant enzyme associated with HDL, showed inverse association with the presence of CHD but were not related to the severity of disease in terms of number of diseased vessels [14].It is not clear that measuring plasma concentrations of HDL-C are sufficient to capture the functional variations in HDL particles along with the associated cardiovascular risk. Therefore, it is highly essential to evaluate functional characteristics of HDL, such as antioxidant and antiinflammatory functions as well as HDL-associated biomarkers that better predict cardiovascular risk.…”

Section: Introductionmentioning

confidence: 97%

Functionally Defective High Density Lipoprotein is Pro-Oxidant: a Deviation from Normal Atheroprotective Character

Sini¹,

Jayakumari

2013

IJNFS

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High-density lipoprotein is a potential life saving antiatherogenic molecule. However, not all HDL is functionally similar, it can become dysfunctional and may increase atherosclerotic risk. At present, it is unknown, which structural alterations of HDL are essential accounting for its defective functionality and the precise pro-atherogenic mechanisms of action. This study is aimed at identification of the possible prevalence of dysfunctional HDL in subjects and its compositional and functional characterization in comparison to that of functional HDL. HDL was isolated from serum by ultracentrifugation and subjected to functional assays. HDL from majority of healthy subjects showed remarkable antioxidant property by inhibiting LDL oxidation. However, in those healthy subjects with systemic oxidative stress and inflammatory response as well as in those with known coronary heart disease, HDL was dysfunctional and promoted LDL oxidation. Dysfunctional HDL was truly pro-oxidant as it induced intracellular reactive oxygen species formation in cultured monocytes/macrophages. Functional deficiency in HDL did not show any association with HDL-cholesterol content. However, its characterization showed an enrichment of triglycerides, phospholipids, lipid peroxides, and diminished activity of paraoxonase-1, compared to functional HDL, which might render the particle dysfunctional and pro-oxidant.This study demonstrates the prevalence of dysfunctional HDL even among healthy subjects, despite normal HDL-C level, and in majority of subjects with known CHD, which is pro-oxidant in nature that might promote vascular inflammation and atherogenesis. The functional assay of HDL could lead to improved predictive accuracy of cardiovascular disease risk associated with circulating HDL.

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High Prevalence of Low Serum Paraoxonase-1 in Subjects with Coronary Artery Disease

Cited by 42 publications

References 24 publications

Ghrelin, Nitrite and Paraoxonase/Arylesterase Concentrations in Cement Plant Workers

Ghrelin, Nitrite and Paraoxonase/Arylesterase Concentrations in Cement Plant Workers

Serum antioxidants and trace minerals as influenced by vitamins, probiotics and proteins in broiler breeders

Functionally Defective High Density Lipoprotein is Pro-Oxidant: a Deviation from Normal Atheroprotective Character

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