High prevalence of low HDL cholesterol concentrations and mixed hyperlipidemia in a Mexican nationwide survey

Abstract

The prevalence of lipid abnormalities revealed in a survey done in 417 Mexican cities is described. Information was obtained on 15,607 subjects, aged 20 to 69 years. In this report, only samples obtained after a 9-to 12-h fast were included (2,256 cases: 953 men and 1,303 women). The population is representative of Mexican urban adults. Mean lipid concentrations were: cholesterol, 4.80 mmol/l; triglycerides, 2.39 mmol/l; HDL cholesterol, 1.00 mmol/l; and LDL cholesterol, 3.06 mmol/l. The most prevalent abnormality was HDL cholesterol below 0.9 mmol/l (46.2% for men and 28.7% for women). Hypertriglyceridemia ( Ͼ 2.26 mmol/l) was the second most prevalent abnormality (24.3%). Severe hypertriglyceridemia ( Ͼ 11.2 mmol/l) was observed in 0.42% of the population. Increased LDL cholesterol ( у 4.21 mmol/l) was observed in 11.2% of the sample. Half of the hypertriglyceridemic subjects had a mixed dyslipidemia or low HDL cholesterol. More than 50% of the low HDL cholesterol cases were not related to hypertriglyceridemia. Insulin resistance was found in 59% of them.In conclusion, the prevalence of hypoalphalipoproteinemia and other forms of dyslipidemia in Mexican adults is very high and it is among the highest previously reported worldwide. -Aguilar-Salinas, C. A

Type 1 Diabetes Care in Mexico: An Analysis of the RENACED-DT1 National Registry

“…The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research (DCCT-EDIC) found that obesity prevalence, in the intensive treatment arm, increased from 1% at baseline in the DCCT Study to 31% at 12-year follow-up of the EDIC Study 27 . Mexico has one of the highest prevalence of metabolic diseases worldwide, including mixed dyslipidemia, hypoalphalipoproteinemia, hypertriglyceridemia, and obesity 28 . The evolution of PWT1D in Mexico, who may have other metabolic diseases, deserves a closer surveillance.…”

TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia

“…These families were recruited in the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ) in Mexico City, using the inclusion and exclusion criteria described previously [14,15]. The Mexican age-specific and sex-specific (age/sex-specific) 90th percentiles for TC and TG [16] were used to classify the FCHL affection status. A total of 58 individuals were classified as type 2 diabetes-affected using the American Diabetes Association criteria [17].…”

The Clinical Significance of MIF Serum-Level as an Early Predictive Marker of Cardiovascular Risk in Patients with Vitiligo

“…The increase of pro-inflammatory cytokines such as IL-1α, IL-6, and TNF-α produce a chronic subclinical inflammatory state that would lead vitiligo patients to an increased predisposition for metabolic disorders, atherosclerosis, and cardiovascular damage [5,6]. Three papers have evaluated CR in patients with…”

“…High levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 alpha (IL-1α), and interleukin-6 (IL-6) have been observed in the lesions of vitiligo patients; [5]. Similarly, high granulocyte-macrophage colony-stimulating factors have been found in the serum [6].…”