High Prevalence of Lipid Abnormalities among Antiretroviral-Naive HIV-Infected Asian Children with Mild-To-Moderate Immunosuppression

Kanjanavanit, Suparat; Puthanakit, Thanyawee; Vibol, Ung; Kosalaraksa, Pope; Hansudewechakul, Rawiwan; Ngampiyasakul, Chaiwat; Wongsawat, Jurai; Luesomboon, Wicharn; Wongsabut, Jiratchaya; Mahanontharit, Apicha; Saphonn, Vonthanak; Ananworanich, Jintanat; Ruxrungtham, Kiat

doi:10.3851/imp1897

Cited by 22 publications

(33 citation statements)

References 21 publications

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“…This may be explained by the fact that most studies have been done in adults and also populations different from ours. Also other factors that affect HDL include genetics and environmental factors like alcohol consumption [9,12,13]. These differences in the previous study populations may explain the difference in the prevalence of HDL seen in this study population.…”

Section: Discussionmentioning

confidence: 96%

“…It was important to consider HDL in the study because HDL has been shown to be cardio-protective [11]. Studies that included all the 4 lipids have found a relatively high prevalence [9]. There are not many studies explaining low HDL among children.…”

Section: Discussionmentioning

confidence: 99%

“…Dyslipidemia was defined as any of the following: Triglyceridde > 130mg/dL, total cholesterol > 200 mg/dL, low density lipoproteins > 130mg/dL and high density lipoproteins ≤ 40mg/ dL [6,9]. Hyperlipidemia was defined as elevated Total cholesterol, elevated Triglyceride, elevated LDL and low HDL.…”

Section: Methodsmentioning

confidence: 99%

“…There is a scale up of HAART use in Uganda with about 24,735 children below 15 years on HAART by 2011 [3]. While HAART has improved and prolonged life, it has been associated with metabolic abnormalities that predispose patients to a poor quality of life [4,5] HAART is associated with lipid abnormalities (dyslipidemia) like: increase in low density lipoproteins (LDL), triglycerides (TG), cholesterol and low high density lipoproteins (HDL), [6–9]. These, together with chronic HIV associated inflammation and activation of the immune system, may result in damage to the arteries.…”

Section: Introductionmentioning

confidence: 99%

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Dyslipidemia and its Correlates among HIV Infected Children on HAART Attending Mbarara Regional Referral Hospital

Nampijja

Kumbakumba

Bajunirwe

et al. 2017

ICPJL

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Background HAART and chronic HIV associated inflammation has been attributed to abnormal lipids in HIV infected people. Little is known about dyslipidemia among children in Uganda in the era of increasing Highly Active Anti Retroviral Therapy (HAART) use. We determined the prevalence of lipid abnormalities, the correlation of the lipid abnormalities to CD4 count, HIV clinical stage and duration on HAART among HIV infected children. Methods This was a cross-sectional, descriptive and analytical study of HIV infected children age 1–17 years receiving HAART for more than 6 months in Mbarara Regional Referral Hospital. Consent and assent were obtained as appropriate. Sociodemographic, clinical and immunological data were collected and recorded in a questionnaire. A blood sample was taken for lipid profiling. Dyslipidemia was defined as any low HDL (<=40mg/dl), high LDL (>130mg/dl), high TG (>130mg/dl) and a high total cholesterol (>200mg/dl) or a combination of these in the study population. The proportion of children with dyslipidemia was calculated and logistic regression analysis for associated factors. Results The mean age was 118 months (SD 49 months) with 49.5% of the children male and 62.1% had severe HIV disease at initiation of HAART. Mean duration of HAART was 55.6 months (SD 31.2 months). The prevalence of dyslipidemia was 74%. Among the children with dyslipidemia, 56.6% exhibited low HDL, 22% had hypertriglyceridemia, 15.6% had high LDL and 11% had hypercholesterolemia. We found significant association between dyslipidemia and WHO clinical stage at initiation of HAART (AOR 2.9 1.05 – 8.45 p=0.040). Conclusion There was a high prevalence of dyslipidemia associated with severe HIV disease at initiation of HAART among HIV-infected children on HAART.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dyslipidemia and its Correlates among HIV Infected Children on HAART Attending Mbarara Regional Referral Hospital

Nampijja

Kumbakumba

Bajunirwe

et al. 2017

ICPJL

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“…Ainsi, une étude menée chez les PV-VIH naïfs d'ARV a rapporté une fréquence élevée de dyslipidémies avec hypo HDLcholestérolémie et hypertriglycéridémie. Ces auteurs ont aussi trouvé que l'intensité de ces troubles était en rapport avec le niveau de la charge virale plasmatique ARN VIH (Kanjanavanit et al, 2011). La nature des mutations et/ou leur nombre pourraient être à l'origine des troubles lipidiques observés chez les PV-VIH et expliqueraient la variabilité de l'intensité de ces troubles d'un sujet à l'autre.…”

Section: Discussionunclassified

Mutations du gène d’apoprotéine B100 au cours des dyslipidémies chez les sujets vivant avec le VIH

Kone¹,

Toni²,

Edjeme-Ake³

et al. 2018

Int. J. Bio. Chem. Sci

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Apoprotein B100 gene mutations and dyslipidemia in HIV-infected patients ABSTRACT Apolipoproteins constitute part of the lipoproteins complex. They are responsible for their metabolism and transportation. The aim of this study was to investigate the Apolipoprotein B100 gene's exons 26 and 29 mutations in PLHIV having dyslipidemia. This descriptive cross-sectional study included 16 dyslipidemic subjects (5 healthy and 11 HIV-positive). The mutations were investigated by DNA sequencing. Dual nucleotide populations were frequent at mutation points (exon 26: 81.2% and exon 29: 100%). Misense mutations were predominant (exon 26: 94.1% and exon 29: 85.7%) and they were often substitutions of cytosine at position 3329 (47.1%, n = 8/17) and guanine at 454 (71.4%; n=5/7) in exons 26 and 29 respectively.F. KONE et al. / Int.

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Prevalence of Lipodystrophy and Metabolic Abnormalities in HIV-infected African Children after 3 Years on First-line Antiretroviral Therapy

Bwakura-Dangarembizi

Musiime

Szubert

et al. 2015

Pediatric Infectious Disease Journal

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Background:Most pediatric lipodystrophy data come from high-income/middle-income countries, but most HIV-infected children live in sub-Saharan Africa, where lipodystrophy studies have predominantly investigated stavudine-based regimens.Methods:Three years after antiretroviral therapy (ART) initiation, body circumferences and skinfold thicknesses were measured (n = 590), and fasted lipid profile assayed (n = 325), in children from 2 ARROW trial centres in Uganda/Zimbabwe. Analyses compared randomization to long-term versus short-term versus no zidovudine from ART initiation [unadjusted; latter 2 groups receiving abacavir+lamivudine+non-nucleoside-reverse-transciptase-inhibitor (nNRTI) long-term], and nonrandomized (confounder-adjusted) receipt of nevirapine versus efavirenz.Results:Body circumferences and skinfold thicknesses were similar regardless of zidovudine exposure (P > 0.1), except for subscapular and supra-iliac skinfolds-for-age which were greater with long-term zidovudine (0.006 < P < 0.047). Circumferences/skinfolds were also similar with efavirenz and nevirapine (adjusted P > 0.09; 0.02 < P < 0.03 for waist/waist-hip-ratio). Total and high-density lipoprotein (HDL)-cholesterol, HDL/triglyceride-ratio (P < 0.0001) and triglycerides (P = 0.01) were lower with long-term zidovudine. Low-density lipoprotein (LDL)-cholesterol was higher with efavirenz than nevirapine (P < 0.001). Most lipids remained within normal ranges (75% cholesterol, 85% LDL and 100% triglycerides) but more on long-term zidovudine (3 NRTI) had abnormal HDL-cholesterol (88% vs. 40% short/no-zidovudine, P < 0.0001). Only 8/579(1.4%) children had clinical fat wasting (5 grade 1; 3 grade 2); 2(0.3%) had grade 1 fat accumulation.Conclusions:Long-term zidovudine-based ART is associated with similar body circumferences and skinfold thicknesses to abacavir-based ART, with low rates of lipid abnormalities and clinical lipodystrophy, providing reassurance where national programs now recommend long-term zidovudine. Efavirenz and nevirapine were also similar; however, the higher LDL observed with efavirenz and lower HDL observed with zidovudine suggests that zidovudine+lamivudine+efavirenz should be investigated in future.

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High Prevalence of Lipid Abnormalities among Antiretroviral-Naive HIV-Infected Asian Children with Mild-To-Moderate Immunosuppression

Cited by 22 publications

References 21 publications

Dyslipidemia and its Correlates among HIV Infected Children on HAART Attending Mbarara Regional Referral Hospital

Dyslipidemia and its Correlates among HIV Infected Children on HAART Attending Mbarara Regional Referral Hospital

Mutations du gène d’apoprotéine B100 au cours des dyslipidémies chez les sujets vivant avec le VIH

Prevalence of Lipodystrophy and Metabolic Abnormalities in HIV-infected African Children after 3 Years on First-line Antiretroviral Therapy

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