High prevalence of human rhinovirus C infection in Thai children with acute lower respiratory tract disease

Linsuwanon, Piyada; Payungporn, Sunchai; Samransamruajkit, Rujipat; Posuwan, Nawarat; Makkoch, Jarika; Theanboonlers, Apiradee; Poovorawan, Yong

doi:10.1016/j.jinf.2009.05.009

Cited by 125 publications

(140 citation statements)

References 33 publications

Supporting

Mentioning

120

Contrasting

Order By: Relevance

“…In a prospective study of preschool children hospitalised with acute respiratory illness or fever, RV-C infections accounted for 46% of RV-positive samples and were significantly associated with an asthma diagnosis at hospital discharge compared to patients with RV-A (55 versus 36%, respectively) [50]. This result has now been duplicated in various settings, suggesting that this novel group might cause a substantial burden in paediatric asthma [51][52][53].…”

Section: Infection Among Factors Precipitating Asthma Exacerbationsmentioning

confidence: 91%

Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers

Xepapadaki¹,

Papadopoulos²

2010

European Respiratory Journal

View full text Add to dashboard Cite

Respiratory infections have been implicated in the origin and exacerbation of asthma in a variety of ways; however, systemisation of this knowledge in a way helpful for disease management remains suboptimal.Several conceptual issues need to be taken into account: the fact that the effects of an infection may vary according to genetic background, the current immune status of the host, and parallel environmental stimuli, in addition to the particular infectious agent itself. Moreover, childhood is a very special period because of the continuous processes taking place, such as neural, immune and respiratory maturation.Epidemiological studies have convincingly demonstrated that the majority of asthma exacerbations, in both adults and children, follow viral upper respiratory tract infections. Asthma exacerbations are still often unresponsive to current asthma treatment, and new therapeutic approaches are required.This review presents current knowledge on the associations between infection and exacerbation of established asthma with respect to definitions, epidemiology, mechanisms and treatment.

show abstract

Section: Infection Among Factors Precipitating Asthma Exacerbationsmentioning

confidence: 91%

Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers

Xepapadaki¹,

Papadopoulos²

2010

European Respiratory Journal

View full text Add to dashboard Cite

show abstract

“…Viral RNA was extracted using the Exgene Viral DNA/ RNA kit (GeneAll, Seoul, Korea) according to the manufacturer's instructions. We initial screened for enterovirus genome region spanning the conserved 5 0 untranslated region (5 0 UTR) and VP4/VP2 gene using conventional RT-PCR as previously described [6]. Subsequently, partial VP1 region was amplified with degenerate primers to identify the enterovirus species [8].…”

mentioning

confidence: 99%

High prevalence of coxsackievirus A2 in children with herpangina in Thailand in 2015

et al. 2017

Self Cite

View full text Add to dashboard Cite

Coxsackievirus (CV) is a member of the genus Enterovirus and the family Picornaviridae. CV infection can cause herpangina, a disease characterized by multiple ulcers on the tonsils and soft palate affecting mostly young children. CV strains are categorized by serotypes. Unfortunately, serotypes responsible for infections in patients are often undetermined. This knowledge gap partly contributes to the ineffective prevention and control of CV-associated herpangina in Southeast Asia. To characterize the viral etiology of children presented with herpangina, 295 throat swabs were tested for human enterovirus infection. Using RT-PCR specific for the viral 5 0 UTR/VP2 and the VP1 regions, two most frequent CV types found in these samples were CV-A2 (33.33%, 40/120) and CV-A4 (15.8%, 19/120). Phylogenetic analysis of the VP1 gene demonstrated that the CV-A2 strains in this study not only were closely related to those previously identified in Asia and Europe, but the majority clustered into a distinct group. Thus, infection predominantly by CV-A2 and CV-A4 caused herpangina in 2015 in Thailand.

show abstract

“…A number of studies have shown that HRV-C is the most common HRV species associated with acute asthma attacks severe enough to result in children presenting to hospital (18)(19)(20)(21), and further studies have shown that it also causes more severe asthma attacks than other rhinoviruses (22) and all other viruses (23).…”

mentioning

confidence: 99%

Human Rhinovirus Species C Infection in Young Children with Acute Wheeze Is Associated with Increased Acute Respiratory Hospital Admissions

Cox

Bizzintino

Ferrari³

et al. 2013

Am J Respir Crit Care Med

155

122

View full text Add to dashboard Cite

Rationale: Human rhinovirus species C (HRV-C) is the most common cause of acute wheezing exacerbations in young children presenting to hospital, but its impact on subsequent respiratory illnesses has not been defined. Objectives: To determine whether acute wheezing exacerbations due to HRV-C are associated with increased hospital attendances due to acute respiratory illnesses (ARIs). Methods: Clinical information and nasal samples were collected prospectively from 197 children less than 5 years of age, presenting to hospital with an acute wheezing episode. Information on hospital attendances with an ARI before and after recruitment was subsequently obtained. Measurements and Main Results: HRV was the most common virus identified at recruitment (n ¼ 135 [68.5%]). From the 120 (88.9%) samples that underwent typing, HRV-C was the most common HRV species identified, present in 81 (67.5%) samples. Children with an HRV-related wheezing illness had an increased risk of readmission with an ARI (relative risk, 3.44; 95% confidence interval, 1.17-10.17; P ¼ 0.03) compared with those infected with any other virus. HRV-C, compared with any other virus, was associated with an increased risk of a respiratory hospital admission before (49.4% vs. 27.3%, respectively; P ¼ 0.004) and within 12 months (34.6% vs. 17.0%; P ¼ 0.01) of recruitment. Risk for subsequent ARI admissions was further increased in atopic subjects (relative risk, 6.82; 95% confidence interval, 2.16-21.55; P ¼ 0.001). Admission risks were not increased for other HRV species. Conclusions: HRV-C-related wheezing illnesses were associated with an increased risk of prior and subsequent hospital respiratory admissions. These associations are consistent with HRV-C causing recurrent severe wheezing illnesses in children who are more susceptible to ARIs. Keywords: human rhinovirus; acute wheezing illnesses; hospital admissions; pediatricsNumerous studies have demonstrated that wheezing associated with certain viruses in early childhood is an independent risk factor for subsequent wheezing illnesses and the development of asthma (1-7). Most earlier reports focused on respiratory syncytial virus (RSV) bronchiolitis in infancy and recurrent wheezing (1-3, 8, 9), but more recent research has shown that wheezing episodes due to human rhinovirus (HRV) have a stronger association than RSV with further wheezing episodes and asthma in early childhood (4,5,7,9).Previously, HRV-A and -B (10-12) were the only known HRV species, but improved virological detection methods using polymerase chain reaction (PCR) and sequencing (13-15) have revealed another species of rhinovirus, C (16,17). A number of studies have shown that HRV-C is the most common HRV species associated with acute asthma attacks severe enough to result in children presenting to hospital (18-21), and further studies have shown that it also causes more severe asthma attacks than other rhinoviruses (22) and all other viruses (23).These studies raise the issue of whether HRV-C also influences subsequent acute wheezing e...

show abstract

High prevalence of human rhinovirus C infection in Thai children with acute lower respiratory tract disease

Abstract: HRV-C represents the predominant species and is one of the etiologic agents in acute lower respiratory tract infection, causes of wheezing and asthma exacerbation in infants and young children in Thailand.

Cited by 125 publications

References 33 publications

Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers

Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers

High prevalence of coxsackievirus A2 in children with herpangina in Thailand in 2015

Human Rhinovirus Species C Infection in Young Children with Acute Wheeze Is Associated with Increased Acute Respiratory Hospital Admissions

Contact Info

Product

Resources

About