High prevalence of human metapneumovirus subtype <scp>B</scp> in cases presenting as severe acute respiratory illness: an experience at tertiary care hospital

Jain, Bhawana; Singh, Ajay; Dangi, Tanushree; Agarwal, Anjali; Verma, Anil K.; Dwivedi, Manish Kumar; Singh, Kamleshwar; Jain, Amita

doi:10.1111/crj.12064

Cited by 22 publications

(11 citation statements)

References 42 publications

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“…Of all the clinical features recorded, cough (100.0%, 101/101), abnormal pulmonary breath sound (91.1%, 92/101), fever (88.1%, 89/101), expectoration (77.2%, 78/101), coryza (50.5%, 51/101) and wheezing (46.5%, 47/101) occurred frequently in patients who are HMPV positive, similar to those reported previously. 16 29 52 55 …”

Section: Discussionmentioning

confidence: 99%

Epidemiological and clinical features of human metapneumovirus in hospitalised paediatric patients with acute respiratory illness: a cross-sectional study in Southern China, from 2013 to 2016

Zhang

Liu

et al. 2018

BMJ Open

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ObjectivesHuman metapneumovirus (HMPV) is one of the most important respiratory viral pathogens affecting infants and children worldwide. Our study describes the epidemiological and clinical characteristics of HMPV present in patients hospitalised with acute respiratory illness (ARI) in Guangzhou, Southern China.Study designA cross-sectional study.SettingTwo tertiary hospitals in Guangzhou.Participants and methodsThroat swabs were collected over a 3-year period from 5133 paediatric patients (≤14 years) hospitalised with ARI. Patients who are HMPV positive with clinical presentations (101/103) were recorded for further analysis.ResultsOf the 5133 patients included in the study, 103 (2.0%) were positive for HMPV. HMPV was more prevalent in children ≤5 years (2.2%, 98/4399) compared with older children (>5–14 years) (0.7%, 5/734) (P=0.004). Two seasonal HMPV peaks were observed each year and mainly occurred in spring and early summer. Overall, 18.4% (19/103) of patients who are HMPV positive were codetected with other pathogens, most frequently respiratory syncytial virus (36.8%, 7/19). Patients who are HMPV positive presented with a wide spectrum of clinical features, including cough (100.0%, 101/101), abnormal pulmonary breath sound (91.1%, 92/101), fever (88.1%, 89/101), expectoration (77.2%, 78/101), coryza (50.5%, 51/101) and wheezing (46.5%, 47/101). The main diagnosis of patients who are HMPV positive was bronchopneumonia (66.7%, 56/84). Fever (≥38˚C) (91.6%, 76/83) was detected more often in patients with only HMPV detected than in patients with HMPV plus other pathogen(s) detected (72.2%, 13/18) (P=0.037), whereas diarrhoea was more common in patients with HMPV plus other pathogen(s) detected (22.2%, 4/18), compared with patients with HMPV only (3.6%, 3/83) (P=0.018).ConclusionsHMPV is an important respiratory pathogen in children with ARI in Guangzhou, particularly in children ≤5 years old. HMPV has a seasonal variation. Bronchopneumonia is a major diagnosis in patients who are HMPV positive.

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Section: Discussionmentioning

confidence: 99%

Epidemiological and clinical features of human metapneumovirus in hospitalised paediatric patients with acute respiratory illness: a cross-sectional study in Southern China, from 2013 to 2016

Zhang

Liu

et al. 2018

BMJ Open

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“…31 hMPV acts as an enhancer of COPD 59 and patients with COPD are more prone to hMPV infection. 60,61 A few reports have also suggested that hMPV infection in children may be associated with a spectrum of central nervous system diseases ranging from febrile seizures to severe encephalitis. 62 hMPV was detected by real-time RT-PCR in asymptomatic children, but they had significantly lower viral loads that those found in symptomatic children.…”

Section: Clinical Featuresmentioning

confidence: 99%

Human metapneumovirus: review of an important respiratory pathogen

Panda

Mohakud

Pena

et al. 2014

International Journal of Infectious Diseases

155

146

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Human metapneumovirus (hMPV), discovered in 2001, most commonly causes upper and lower respiratory tract infections in young children, but is also a concern for elderly subjects and immune-compromised patients. hMPV is the major etiological agent responsible for about 5% to 10% of hospitalizations of children suffering from acute respiratory tract infections. hMPV infection can cause severe bronchiolitis and pneumonia in children, and its symptoms are indistinguishable from those caused by human respiratory syncytial virus. Initial infection with hMPV usually occurs during early childhood, but re-infections are common throughout life. Due to the slow growth of the virus in cell culture, molecular methods (such as reverse transcriptase PCR (RT-PCR)) are the preferred diagnostic modality for detecting hMPV. A few vaccine candidates have been shown to be effective in preventing clinical disease, but none are yet commercially available. Our understanding of hMPV has undergone major changes in recent years and in this article we will review the currently available information on the molecular biology and epidemiology of hMPV. We will also review the current therapeutic interventions and strategies being used to control hMPV infection, with an emphasis on possible approaches that could be used to develop an effective vaccine against hMPV.

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“…Occurrences of LRTI should be assessed on a case-by-case basis and the Immunodeficiency Scoring Index (Shah et al, 2014) may be useful here. However, it must be appreciated that LRTI HMPV in adults, when compared to RSV and influenza, is associated with similar complication rates, including intensive care unit (ICU) admission, mechanical ventilation, length of hospitalization and length of stay in the ICU Jain et al, 2014). The high prevalence of previous infection in the population means that relatively high titres of HMPV neutralizing antibodies are found in pooled IVIG.…”

Section: Human Metapneumovirusmentioning

confidence: 99%

BCSH/BSBMT/UK clinical virology network guideline: diagnosis and management of common respiratory viral infections in patients undergoing treatment for haematological malignancies or stem cell transplantation

et al. 2016

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SummaryA joint working group established by the Haemato-oncology subgroup of the British Committee for Standards in Haematology, the British Society for Bone Marrow Transplantation and the UK Clinical Virology Network has reviewed the available literature and made recommendations for the diagnosis and management of respiratory viral infections in patients with haematological malignancies or those undergoing haematopoietic stem cell transplantation. This guideline includes recommendations for the diagnosis, prevention and treatment of respiratory viral infections in adults and children. The suggestions and recommendations are primarily intended for physicians practising in the United Kingdom.

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High prevalence of human metapneumovirus subtype B in cases presenting as severe acute respiratory illness: an experience at tertiary care hospital

Abstract: HMPV has emerged as an important cause of SARI in children <12 years of age. Alternative predominance of RSV and HMPV is an important observation.

Cited by 22 publications

References 42 publications

Epidemiological and clinical features of human metapneumovirus in hospitalised paediatric patients with acute respiratory illness: a cross-sectional study in Southern China, from 2013 to 2016

Epidemiological and clinical features of human metapneumovirus in hospitalised paediatric patients with acute respiratory illness: a cross-sectional study in Southern China, from 2013 to 2016

Human metapneumovirus: review of an important respiratory pathogen

BCSH/BSBMT/UK clinical virology network guideline: diagnosis and management of common respiratory viral infections in patients undergoing treatment for haematological malignancies or stem cell transplantation

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