High prevalence of hepatitis G virus (HGV) infection in renal transplantation

Berthoux, P; Dejean, Cristina Beatriz; Cecillon, S; Batie, M; Berthoux, F

doi:10.1093/ndt/13.11.2909

Cited by 8 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the fact that, no obvious evidence exists regarding the role of GBV-C in liver damage, it appears to play a minor role in acute hepatitis, even in immunosuppressed patients ( 3 , 15 ). Nevertheless, its effects on kidney injury and graft survival cannot be ignored ( 27 - 30 ). Of course, more studies are needed to confirm these observations.…”

Section: Discussionmentioning

confidence: 99%

GB virus C Viremia and Anti-E2 Antibody Response Among Hemodialysis Patients in Gorgan, Iran

Kelishadi

Mojerloo²,

Moradi

et al. 2014

Jundishapur J Microbiol

View full text Add to dashboard Cite

Background:GB Virus C is a blood-borne virus and a member of Flaviviridae, like hepatitis C that is distributed globally and puts hemodialysis patients at high risk of developing liver disease. The clinical significance of GBV-C in this population remains unclear.Objectives:The current study aimed to evaluate GBV-C infection among hemodialysis patients.Patients and Methods:Totally, 149 patients receiving hemodialysis were included in the study. The detection of GBV-C sequences in plasma was done by the nested Reverse transcription polymerase chain reaction (RT-PCR) using specific primers selected from highly conserved regions of 5' UTR of GBV-C and antibodies to the envelope protein of GBV-C (anti-E2 GBV-C antibody) were analyzed by also serological methods. In addition, Hepatitis B surface antigen (HBsAg), Hepatitis B core antibody (HBcAb) IgM, anti- Hepatitis C virus (HCV) and anti- hepatitis E virus (HEV) Ab was determined in patients who were GBV-C RNA and anti-E2 GBV-C antibody positive.Results:The total prevalence of GBV-C infection was 14.7% (95%CI: 0.09-0.21) among patients receiving hemodialysis. The rate of GBV-C viremia and anti-E2 antibody positivity were 6.04% and 10.73%, respectively. Among the subjects who were positive for GBV-C, 27.27% (95% CI: 0.02-0.09), 45.45% (95% CI: 0.03-0.11), 59.9% (95% CI: 0.06-0.16) and 0% (95% CI: 0.01-0.07) were positive for anti-HCV, anti-HBsAg, anti-HBc IgM and anti-(HEV) Ab, respectively. In addition, the rate of both anti-HBc IgM /anti-HCV/ HBsAg and anti-HBc IgM /anti-HCV positivity in GBV-C infected cases were 9.09%. The liver enzymes were normal in all of them. There was significant difference between GBV-C exposures with viral hepatitis co-infection, but there was no correlation between GBV-C exposure with gender, age, ethnicity, time on dialysis and history of blood transfusions. A relatively high frequency of positivity GBV-C-exposure among hemodialysis patients suggested that the transmission route for GBV-C may be nosocomial transmission, and via transfusions.Conclusions:The current study found a relatively high frequency of positivity GBV-C-exposure among the patients receiving hemodialysis in the area understudy. Nosocomial transmission seems to be the main route of GBV-C infection in the area.

show abstract

Section: Discussionmentioning

confidence: 99%

GB virus C Viremia and Anti-E2 Antibody Response Among Hemodialysis Patients in Gorgan, Iran

Kelishadi

Mojerloo²,

Moradi

et al. 2014

Jundishapur J Microbiol

View full text Add to dashboard Cite

show abstract

“…HCV and HGV viremia were detected according to already published techniques [5][6][7] on different serum samples (stored at -80°C) before and during the course of transplantation.…”

Section: Methodsmentioning

confidence: 99%

Membranoproliferative Glomerulonephritis with Subendothelial Deposits (Type 1) Associated with Hepatitis G Virus Infection in a Renal Transplant Recipient

et al. 1999

View full text Add to dashboard Cite

Background: Infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) is a well-known etiology for membranoproliferative glomerulonephritis (MPGN) with subendothelial deposits (MPGN type 1). Material and Methods: The newly discovered hepatitis G virus (HGV) is currently under active investigation. We report the first case of de novo MPGN type 1 associated with HGV infection in a young male renal transplant recipient who manifested glomerulonephritis (GN) with proteinuria 7 years after transplant, and whose original disease was chronic obstructive pyelonephritis secondary to nephrolithiasis. Results: Serum markers for HBV and HCV infections were negative. HGV infection was detected by specific double-nested reverse transcriptase-polymerase chain reaction (RT-PCR) in sera (positive HGV viremia) 2.5 years after renal transplantation. By specific in situ RT-PCR, the presence of the HGV genome was detected in peripheral blood mononuclear cells and in the kidney biopsy (glomeruli and tubules), but not in the liver. Conclusion: This report adds new information on the role of HGV infection in the occurrence of de novo GN (MPGN type 1) in renal transplantation.

show abstract

“…Finally, several reports have been published on GB virus C and TTV in KTRs, peaking in 1997 and 2003, respectively, and then decreasing. Despite the fact that GB virus C and TTV were first found in serum samples of patients with unexplained hepatitis , most papers have dismissed significant roles for these viruses as etiologic agents of diseases in immune‐competent individuals and in KTRs (Supplementary Table).…”

Section: Newly Discovered Viruses In Ktrsmentioning

confidence: 99%

Emerging viral diseases in kidney transplant recipients

Moal

Zandotti²,

Colson

2012

Reviews in Medical Virology

View full text Add to dashboard Cite

Viruses are the most important cause of infections and a major source of mortality in Kidney Transplant Recipients (KTRs). These patients may acquire viral infections through exogenous routes including community exposure, donor organs, and blood products or by endogenous reactivation of latent viruses. Beside major opportunistic infections due to CMV and EBV and viral hepatitis B and C, several viral diseases have recently emerged in KTRs. New medical practices or technologies, implementation of new diagnostic tools, and improved medical information have contributed to the emergence of these viral diseases in this special population. The purpose of this review is to summarize the current knowledge on emerging viral diseases and newly discovered viruses in KTRs over the last two decades. We identified viruses in the field of KT that had shown the greatest increase in numbers of citations in the NCBI PubMed database. BKV was the most cited in the literature and linked to an emerging disease that represents a great clinical concern in KTRs. HHV-8, PVB19, WNV, JCV, H1N1 influenza virus A, HEV, and GB virus were the main other emerging viruses. Excluding HHV8, newly discovered viruses have been infrequently linked to clinical diseases in KTRs. Nonetheless, pathogenicity can emerge long after the discovery of the causative agent, as has been the case for BKV. Overall, antiviral treatments are very limited, and reducing immunosuppressive therapy remains the cornerstone of management.

show abstract

High prevalence of hepatitis G virus (HGV) infection in renal transplantation

Abstract: HGV infection prevalence is high (44%) in RTR, but clearly independent of HCV status and/or the geographical origin of the recipients. This data indicates a different epidemiology as compared to our HCVs previous experience.

Cited by 8 publications

References 0 publications

GB virus C Viremia and Anti-E2 Antibody Response Among Hemodialysis Patients in Gorgan, Iran

GB virus C Viremia and Anti-E2 Antibody Response Among Hemodialysis Patients in Gorgan, Iran

Membranoproliferative Glomerulonephritis with Subendothelial Deposits (Type 1) Associated with Hepatitis G Virus Infection in a Renal Transplant Recipient

Emerging viral diseases in kidney transplant recipients

Contact Info

Product

Resources

About