High prevalence of hepatitis C virus infection in the largest province of Pakistan

Idrees, Muhammad; Lal, Amreek; Naseem, Muhammad Tahir; Khalid, Muhammad Uzair

doi:10.1111/j.1751-2980.2008.00329.x

Cited by 63 publications

(76 citation statements)

References 24 publications

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“…This prevalence is lower than that of studies with populations of a similar age in Germany (0.7% and 0.8%) 34,35 , and in the United States (0.3%) 36 . It is also lower that that found in Northern Brazil in volunteers aged below 19 years old (2.1%) 14 and in Pakistan in volunteers aged between 6 and 15 (9.6%) 37 , and corroborates that found in Spain (0%) in a population aged below 19 38 . As foreseeable, due to the young age of participants, our results show a low risk of hepatitis C infection.…”

Section: Resultssupporting

confidence: 62%

Seroprevalence of hepatitis B and hepatitis C markers in adolescents in Southern Brazil

et al. 2011

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Section: Resultssupporting

confidence: 62%

Seroprevalence of hepatitis B and hepatitis C markers in adolescents in Southern Brazil

et al. 2011

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“…The first finding is the identification of chronic HCV infection as a major risk factor for the development of HCC in Pakistan, because anti-HCV was observed in > 63% of patients with HCC. The overall anti-HCV prevalence rate is 14%-15% and HBV carrier rate is 2%-3% in the general population of Pakistan [29,40] . Overall, our data are consistent with the results of studies already reported from high-risk areas for HCC such as Japan, Italy and Spain, where majority of reported HCC cases are HCV-related [6][7][8] .…”

Section: Discussionmentioning

confidence: 99%

“…Qualitative and quantitative detection of HCV RNA HCV qualitative RT-PCR was carried out as described previously [29] . HCV RNA was quantified using a SmartCycler II Real-time PCR (Cepheid, USA), using HCV RNA quantitative kits (Sacace Biotechnologies, Italy) according to the kit protocol.…”

Section: Hbv Qualitative Polymerase Chain Reaction (Pcr)mentioning

confidence: 99%

Hepatitis C virus genotype 3a infection and hepatocellular carcinoma: Pakistan experience

Idrees¹,

Rafique²,

Rehman³

et al. 2009

WJG

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AIM:To assess the association between chronic hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) in Pakistan, and the genotype distribution among these HCC patients. METHODS:One hundred and sixty-one subjects with HCC were included in this study. Liver biopsy was performed on 145 of the patients; sixteen were excluded because they failed to fulfill the inclusion criteria. Qualitative polymerase chain reaction (PCR) was performed for hepatitis B virus and HCV. Samples positive for HCV RNA were genotyped using genotypespecific PCR and confirmed by HCV 5' noncoding region sequencing analysis. RESULTS:Chronic HCV infection was identified a major risk factor (63.44% of tested HCC patients) for the development of HCC. The time from HCV infection to appearance of cancer was 10-50 years. In the HCC patient population, broader distributions of genotypes were present with genotype 3a as the predominant genotype. Using the type-specific genotyping method, we found HCV genotype 3a in 40.96%, 3b in 15.66%, 1a in 9.63%, and 1b in 2.40% of HCC tissue samples. About 28% of cases were found with mixed genotypes. Two cases were unable to be genotyped because of low viral load. Sixty-six percent of treated patients with cirrhosis had an end of treatment response, but unfortunately they relapsed quickly when the treatment was discontinued, and HCC developed during a median 3.8 years. CONCLUSION:There was a strong association between chronic HCV infection and HCC in Pakistan, and between HCV genotype 3a and HCC.

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“…A large number of patients, almost 26% got the infection because they were administered intravenous injections from the GP clinics, which were recognized for reusing the syringes [29]. People who got the injections were more likely to get HCV infection as compared to those who did not get the injections as shown in Table 3 [43].…”

Section: A Unnecessary Therapeutic Injections: Pakistan Wasmentioning

confidence: 87%

“…Several studies have shown that multiple and unnecessary use of injections, unsafe medical/ surgical procedures, use of contaminated razors by barbers, ear, nose piercing, blood transfusions and needle stick injuries (NSI) are major risk factors for HCV infection in Pakistan.29 Following Figure 3 shows the prevalence of HCV infection in Pakistan due to different risk factors ranging from 27% because of multiple use of needles to 2% due to needle stick injuries [29].…”

Section: Common Risk Factors For Hcv Transmission In Pakistanmentioning

confidence: 99%

Risk Factors of Hepatitis C in Pakistan

Mahmood¹

2017

GHOA

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Pakistan is facing an epidemic of hepatitis C in the country. Almost 10 million people are affected with hepatitis C in Pakistan. Most of the people are unaware of their health status because the disease is asymptomatic in its initial course. The major causes of disease spread are unsafe blood transfusions, re-use of therapeutic syringes, unsafe medical and surgical practices, shaving at barbers, ear and nose piercing. Pakistan is a middle income country and has limited resources. Therefore, it should more focus on devising and implementing the effective preventive strategies to reduce the disease burden of hepatitis C.

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High prevalence of hepatitis C virus infection in the largest province of Pakistan

Abstract: The study showed a high seroprevalence of anti-HCV antibodies in a general and apparently healthy population of the Punjab province of Pakistan. Drug injection, blood transfusion and needle stuck were the factors most strongly associated with HCV infection.

Cited by 63 publications

References 24 publications

Seroprevalence of hepatitis B and hepatitis C markers in adolescents in Southern Brazil

Seroprevalence of hepatitis B and hepatitis C markers in adolescents in Southern Brazil

Hepatitis C virus genotype 3a infection and hepatocellular carcinoma: Pakistan experience

Risk Factors of Hepatitis C in Pakistan

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