High prevalence of hepatitis B virus subgenotypes A1 and D4 in Maranhão state, Northeast Brazil

Barros, Lena María; Gomes‐Gouvêa, Michele Soares; Kramvis, Anna; Mendes-Corrêa, Maria Cássia; Santos, Alexsandro dos; Souza, Letícia Alana Barros; Santos, Max Diego Cruz; Carrilho, Flair José; Domicini, Arnaldo de Jesus; Pinho, João Renato Rebello; Ferreira, Adalgisa de Souza Paiva

doi:10.1016/j.meegid.2014.03.007

Cited by 29 publications

(24 citation statements)

References 43 publications

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“…This subgenotype is not frequent however in Haiti, or in Martnique [ 31 , 32 ]. HBV subgenotype D4 was also found very frequently in Maranhao state, Northeast Brazil, together with subgenotype A1 [ 34 ]. The authors suggest that HBV D4 might have been more prevalent in Africa in the past, during slave trade.…”

Section: Discussionmentioning

confidence: 99%

HBV Genotypic Variability in Cuba

et al. 2015

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The genetic diversity of HBV in human population is often a reflection of its genetic admixture. The aim of this study was to explore the genotypic diversity of HBV in Cuba. The S genomic region of Cuban HBV isolates was sequenced and for selected isolates the complete genome or precore-core sequence was analyzed. The most frequent genotype was A (167/250, 67%), mainly A2 (149, 60%) but also A1 and one A4. A total of 77 isolates were classified as genotype D (31%), with co-circulation of several subgenotypes (56 D4, 2 D1, 5 D2, 7 D3/6 and 7 D7). Three isolates belonged to genotype E, two to H and one to B3. Complete genome sequence analysis of selected isolates confirmed the phylogenetic analysis performed with the S region. Mutations or polymorphisms in precore region were more common among genotype D compared to genotype A isolates. The HBV genotypic distribution in this Caribbean island correlates with the Y lineage genetic background of the population, where a European and African origin prevails. HBV genotypes E, B3 and H isolates might represent more recent introductions.

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Section: Discussionmentioning

confidence: 99%

HBV Genotypic Variability in Cuba

et al. 2015

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“…28 The highest prevalence rates of D4 have been reported in northeastern Brazil (28%), Haiti (17%), Kenya (14.3%) and Rwanda (6.7%). [29][30][31][32] It has been speculated that sub-genotype D4 originated in eastern Africa, where it was more prevalent in the past than it is today, and that its introduction in Haiti and Brazil occurred as a result of the slave trade during the second half of the 18th century. 29,30 We detected LAMr mutations in 17 of the 23 (74%) patients who were HBV viraemic and in whom sequencing was successful.…”

Section: Discussionmentioning

confidence: 99%

“…[29][30][31][32] It has been speculated that sub-genotype D4 originated in eastern Africa, where it was more prevalent in the past than it is today, and that its introduction in Haiti and Brazil occurred as a result of the slave trade during the second half of the 18th century. 29,30 We detected LAMr mutations in 17 of the 23 (74%) patients who were HBV viraemic and in whom sequencing was successful. Interestingly, in all 17 patients the primary mutations located in domain C of the YMDD motif (rtM204I and rtM204V) were always accompanied by at least one secondary/compensatory mutation.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of HBV infection in a cohort of Ugandan HIV-infected patients and rate and pattern of lamivudine-resistant HBV infection in patients receiving antiretroviral therapy

Calisti

Muhindo

Boum

et al. 2015

Trans R Soc Trop Med Hyg

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“…Sequencing was performed using Sanger methodology by using the Big Dye Terminator kit v.3.1 and the primers (three pairs) previously described [Barros et al, ; Gomes‐Gouvêa et al, ]. Electrophoresis was performed using an automatic sequencer (ABI 3500 DNA Sequencer; Applied Biosystems, Foster City, CA).…”

Section: Methodsmentioning

confidence: 99%

“…To S gene sequence characterization, a fragment of 1,306 base pairs comprising part of Pre-S gene and the total S gene were amplified using a nested PCR protocol previously described [Barros et al, 2014;Gomes-Gouvêa et al, 2015].…”

Section: Amplification Quantification and Sequence Analysesmentioning

confidence: 99%

Mutation in the S gene a determinant of the hepatitis B virus associated with concomitant HBsAg and anti‐HBs in a population in Northeastern Brazil

Albuquerque

Sousa

Santos

et al. 2016

Journal of Medical Virology

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Mutations in the a determinant of S gene may develop co-existence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) in the serum of infected hepatitis B virus (HBV) individuals. Mutations in this region may change the antigenicity of HBsAg, which in turn, lead to escape of neutralizing action of anti-HBs antibodies. This study identified individuals with concomitant HBsAg and anti-HBs serological markers in individuals of Maranhão, Northeastern Brazil. Samples from a population-based study were evaluated for HBsAg, anti-HBs, and anti-HBc, and those that tested positive for simultaneous HBsAg and anti-HBs were submitted to HBV DNA quantification and S gene characterization by Sanger sequencing. Mutations were investigated in the a determinant located in major hydrophilic region (MHR) of the S gene. Among 3,984 samples analyzed, 92 (2.3%) were positive for HBsAg and three had the atypical HBsAg and anti-HBs-positive profile (3.26%). The frequency of HBsAg and anti-HBs co-existence was similar to previous studies. Only one individual harbored mutation in the S gene a determinant associated with this profile. Little is known about this phenomenon; however, studies as ours may contribute for future enlightenment of this important issue. J. Med. Virol. 89:458-462, 2017. © 2016 Wiley Periodicals, Inc.

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High prevalence of hepatitis B virus subgenotypes A1 and D4 in Maranhão state, Northeast Brazil

Cited by 29 publications

References 43 publications

HBV Genotypic Variability in Cuba

HBV Genotypic Variability in Cuba

Epidemiology of HBV infection in a cohort of Ugandan HIV-infected patients and rate and pattern of lamivudine-resistant HBV infection in patients receiving antiretroviral therapy

Mutation in the S gene a determinant of the hepatitis B virus associated with concomitant HBsAg and anti‐HBs in a population in Northeastern Brazil

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