High prevalence of hepatitis B virus infection in HIV-negative Castleman's disease

Yuan, Xianggui; Chen, Feifei; Zhu, Yimiao; Hu, Wen; Zhao, Xiaoying; Jin, Jie

doi:10.1007/s00277-011-1388-8

Cited by 9 publications

(10 citation statements)

References 14 publications

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“…[38][39][40][41][42][43] These infections may be pathologic, coincidental, or secondary to iMCD-related immune dysfunction.…”

Section: Candidate Etiological Triggersmentioning

confidence: 99%

“…EBV and a few other candidate viruses have been reported to occur with iMCD even though systematic viral serologies and sequencing studies have not been performed to date. [38][39][40][41][42][43] Comprehensive viral serologies and deep sequencing studies are needed to identify a known or undiscovered virus that may drive iMCD.…”

Section: Virally Driven Hypothesismentioning

confidence: 99%

See 1 more Smart Citation

HHV-8-negative, idiopathic multicentric Castleman disease: novel insights into biology, pathogenesis, and therapy

Fajgenbaum

Rhee

Nabel

2014

Blood

272

265

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Multicentric Castleman's disease (MCD) describes a heterogeneous group of disorders involving proliferation of morphologically benign lymphocytes due to excessive proinflammatory hypercytokinemia, most notably of interleukin-6. Patients demonstrate intense episodes of systemic inflammatory symptoms, polyclonal lymphocyte and plasma cell proliferation, autoimmune manifestations, and organ system impairment. Human herpes virus-8 (HHV-8) drives the hypercytokinemia in all HIV-positive patients and some HIV-negative patients. There is also a group of HIV-negative and HHV-8-negative patients with unknown etiology and pathophysiology, which we propose referring to as idiopathic MCD (iMCD). Here, we synthesize what is known about iMCD pathogenesis, present a new subclassification system, and propose a model of iMCD pathogenesis. MCD should be subdivided into HHV-8-associated MCD and HHV-8-negative MCD or iMCD. The lymphocyte proliferation, histopathology, and systemic features in iMCD are secondary to hypercytokinemia, which can occur with several other diseases. We propose that 1 or more of the following 3 candidate processes may drive iMCD hypercytokinemia: systemic inflammatory disease mechanisms via autoantibodies or inflammatory gene mutations, paraneoplastic syndrome mechanisms via ectopic cytokine secretion, and/or a non-HHV-8 virus. Urgent priorities include elucidating the process driving iMCD hypercytokinemia, identifying the hypercytokine-secreting cell, developing consensus criteria for diagnosis, and building a patient registry to track cases.

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“…[38][39][40][41][42][43] These infections may be pathologic, coincidental, or secondary to iMCD-related immune dysfunction.…”

Section: Candidate Etiological Triggersmentioning

confidence: 99%

Section: Virally Driven Hypothesismentioning

confidence: 99%

HHV-8-negative, idiopathic multicentric Castleman disease: novel insights into biology, pathogenesis, and therapy

Fajgenbaum

Rhee

Nabel

2014

Blood

272

265

View full text Add to dashboard Cite

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“…reported a high incidence of hepatitis B virus infection in HIV-negative Castleman's disease. [8] Here, we report the coexistence of hepatitis B in the patient. The role of hepatitis B in the pathogenesis of Castleman's disease is still not known even though for HIV and HHV-8 it has always been mentioned in the literature.…”

Section: Discussionmentioning

confidence: 95%

“…The role of hepatitis B in the pathogenesis of Castleman's disease is still not known even though for HIV and HHV-8 it has always been mentioned in the literature. [78]…”

Section: Discussionmentioning

confidence: 99%

Castleman's disease associated with calcifying fibrous tumor: A rare association with review of literature

et al. 2019

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Castleman's disease is a rare disease characterized by unicentric or multicentric enlargement of the lymph node, and it is mostly of the hyaline vascular type. Calcifying fibrous tumor is a neoplasm characterized by large areas of hyalinized collagen with paucicellular areas along with dystrophic calcification and scattered lymphoplasmacytic infiltrates. There are only five case reports to describe an association between these two entities. We report a case of a 38-year-old male with seropositivity for hepatitis B virus presenting with a right-sided cervical swelling. Fine-needle aspiration cytology (FNAC) was done, and a diagnosis of follicular hyperplasia was offered. Biopsy confirmed the diagnosis of Castleman's disease. However, there was associated calcifying fibrous tumor in the lymph node induced by trauma due to FNAC.

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“…Epstein-Barr Virus (EBV), HHV-6, hepatitis B virus, cytomegalovirus, toxoplasma, and Mycobacterium tuberculosis have each been reported to co-occur with iMCD, even though most iMCD cases do not report an associated infectious agent [6][7][8][9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Multicentric Castleman's Disease with Mycobacterium cosmeticum Infection

AS¹,

VG²,

Govindan³

et al. 2017

Arch Surg Oncol

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Multicentric Castleman's Disease (MCD) is a rare and poorly understood disorder that straddles the intersections of hematology, oncology, rheumatology, and virology and can be fatal if improperly treated. The etiology of HHV8 negative disease is unknown and only isolated cases of associations with infectious agents have been reported in literature. However the co-occurrence of Mycobacterium cosmeticum with Castleman's disease has never been previously reported in literature. Hence we would like to report a case of Multicentric Castleman's disease with a coexisting M. cosmeticum infection. Keywords: Ulcerative colitis; Imageology; Hypoalbuminemia; FolliclesCase report 58 year old gentleman, a painter by profession, who gives a history of ulcerative colitis for the past six years, was evaluated in medical gastroenterology department of our institution in October 2016, for symptoms of progressively increasing abdominal distension and loss of weight for the past eight months [1].On clinical examination he had right cervical Level II Lymph node enlargement (2 × 1.5 cm) with moderate ascites and splenomegaly. All other systems were unremarkable on examination.At the time of initial presentation his laboratory investigations revealed hypoalbuminemia, with all other parameters within normal limits including ECHO scan. Biopsy from the cervical lymph node was suggestive of Castleman's disease (angiofollicular hyperplasia). On low power microscopy, an increase in the number of follicles in the cortex with the germinal

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High prevalence of hepatitis B virus infection in HIV-negative Castleman's disease

Cited by 9 publications

References 14 publications

HHV-8-negative, idiopathic multicentric Castleman disease: novel insights into biology, pathogenesis, and therapy

HHV-8-negative, idiopathic multicentric Castleman disease: novel insights into biology, pathogenesis, and therapy

Castleman's disease associated with calcifying fibrous tumor: A rare association with review of literature

Multicentric Castleman's Disease with Mycobacterium cosmeticum Infection

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