High prevalence of hepatitis B, C and delta virus infections among blood donors in Mongolia

Tsatsralt-Od, Bira; Takahashi, Masaharu; Nishizawa, Tsutomu; Inoue, Jun; Ulaankhuu, D.; Okamoto, Hiroaki

doi:10.1007/s00705-005-0590-1

Cited by 34 publications

(57 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A 29% HBsAg positivity and 48% anti-HCV positivity were reported among 150 outpatients at two hospitals in Ulaanbaatar [1]. HBV and HCV rates similar to rates in our study were reported by Tsatsralt-Od et al (7.4% HBsAg and 10.7% anti-HCV among 403 blood donors at the same center) [9]. They evaluated the screening tests used at the Blood Center and indicated a proportion of hepatitis viremic blood donors were missed with the present screening test.…”

Section: Discussionsupporting

confidence: 91%

Prevalence of infectious diseases among Mongolian blood donors

Tserenpuntsag

Ouynbileg²,

Nelson

et al. 2008

J Infect Dev Ctries

View full text Add to dashboard Cite

Objectives: This study estimates the prevalence of screened infections: human immunodeficiency (HIV), hepatitis B (HBV) virus, hepatitis C (HCV) virus, brucellosis, and syphilis among Mongolian blood donors. Methods: This report is based on routine data collected from simple questionnaires completed by a sample of consecutive donors visiting the Blood Center between August 2004 and February 2005. Results: Seropositivity rates were as follows: HIV 0%, HBsAg 8.1% (n=185), anti-HCV 8.7% (n=195), brucellosis 3.3% (n=75), and syphilis 2% (n=44). HBsAg seropositivity was concentrated among young donors less than 20 years of age (P<0.01) while anti-HCV seropositivity tended to increase significantly with age. Conclusion: The prevalence of HBV and HCV among Mongolian donors is very high and appears to be differentially distributed by age. The data suggests further studies are warranted to identify key risk factors for blood-borne infections and to develop population-specific interventions to interrupt transmission.

show abstract

Section: Discussionsupporting

confidence: 91%

Prevalence of infectious diseases among Mongolian blood donors

Tserenpuntsag

Ouynbileg²,

Nelson

et al. 2008

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…The rate was comparable to that reported from Lucknow 2.2% (5) , North India 2.5% (25) , Mumbai 2.02% (9) , Pakistan 2.21% (24) , Calcutta 2.8% (4) and Bangladesh 2.4% (17) . When the results of the present study was compared with those reported from similar blood donors of other countries like Cameroon 11.72% (35) , Taiwan 4.5% (32) , Ethiopia 14.4% (27) , Mauritania 20.3% (20) , Thailand 4.51% (21) , Djibouti 10.4% (8) , Mangolia 8.2% (33) , this study showed relatively lower prevalence of the hepatitis-B surface antigen whereas countries like Brazil 1.9% (23) , Iran 1.07% (12) , Turkey1.5% (28) and US Community 0.15% (18) , showed lower HBsAg positivity in comparison to the present study.…”

Section: Discussionmentioning

confidence: 54%

Seroprevalence and risk factors for hepatitis B virus infection among general population in Northern India

Behal

Jain

Behal

et al. 2008

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Background -Infection with hepatitis-B virus has been a significant cause of morbidity claiming more than a million lives every year. Epidemiological data reveals that there are 360 million carriers of hepatitis-B virus throughout the globe and 78% of the world populations' hail from Asia. Though several studies from Indian sub-continent have provided an estimate of the prevalence of this viral infection, there exist only few studies, which reflect the status in the general population. Aim -The present study was designed to investigate the prevalence of hepatitis-B infection in North Indian general population. Methods -The study population comprised of 20,000 healthy blood donors who were screened for hepatitis-B surface antigen (HBsAg) status using third generation ELISA kit. Seroprevalence rate of seropositive donors was calculated and stratified by age, sex and blood groups. Statistical analysis was performed using tests of proportions, chi-square and confidence interval. Results -The study showed that out of 20,000 donors, 450 (2.25%) were HBsAg positive (95% confidence interval (CI), 2.0445-2.4554). Higher prevalence of HbsAg was found among males (440/19235) than females (10/765). The age specific prevalence rose from 1.78% (108/6058) in donors aged 19-25 years to a maximum of 3.03% (96/3161) in donors aged 35-45 years and decreased in older age groups. The peaks were detected in male donors aged 35-45 years and in females aged 25-35 years. Rh-negative blood group donors (21/873) and Rh-positive group donors (429/19127) had almost equivalent prevalence rates of HBsAg. HBsAg was more prevalent in blood group B donors (174/7426) and less prevalent in AB blood group donors (38/2032). Conclusion -It was found that variables including gender and age were significantly associated with HBsAg positivity. HBsAg positivity in our population was statistically not associated with ABO blood groups.

show abstract

“…In previous studies on a total of 538 apparently healthy subjects aged 18-86 years living in Ulaanbaatar, the capital city of Mongolia [Takahashi et al, 2004;Inoue et al, 2005;Tsatsralt-Od et al, 2005a], hepatitis B surface antigen (HBsAg) and/or hepatitis B virus (HBV) DNA, hepatitis C virus (HCV) RNA, and hepatitis delta virus (HDV) RNA were detected in 61 (11.3%), 57 (10.6%), and 47 individuals (8.7%), respectively, with a markedly high prevalence of concurrent HDV viremia among apparently healthy individuals with persistent HBV infection (47/61 or 77.0%), indicating that Mongolia is highly endemic for HBV, HCV and HDV infections in the adult population. However, at present, little or no data on the age-dependent prevalence of infection of these three hepatitis viruses among healthy children in Mongolia are available.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of hepatitis B, C, and delta virus infections among children in Mongolia: Progress in childhood immunization

Tsatsralt-Od

Takahashi

Endo

et al. 2007

Journal of Medical Virology

View full text Add to dashboard Cite

Mongolia is highly endemic for hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis delta virus (HDV) infections among apparently healthy adults. However, the age-specific prevalence of ongoing HBV, HCV, and HDV infections among children in Mongolia remains unknown. Therefore, samples obtained from a total of 655 apparently healthy children of 0.3-15 years of age (307 boys and 348 girls; age, mean +/- standard deviation [SD], 8.4 +/- 4.2 years) living in Mongolia, between October 2005 and January 2006, were tested for serological and molecular markers of HBV, HCV, and HDV infections. Although 88.7% of the 655 children studied were immunized against hepatitis B, 64 (9.8%) tested positive for hepatitis B surface antigen (HBsAg) and/or HBV DNA and 13 (2.0%) for HDV RNA. Twenty-seven children (4.1%) had detectable HCV RNA. Collectively, 82 (12.5%) were viremic for one or more of these viruses, including eight children with dual viremia of HBV/HCV and one child with triple HBV/HCV/HDV viremia. When children without anti-HBc, anti-HCV and anti-HDV IgG (n = 510) served as a control, a history of hospitalization was significantly associated with HBV viremia (P < 0.0001), anti-HBc positivity (P < 0.0001), and HCV viremia (P = 0.0001). HBsAg mutation was found in 18 (31.6%) of the 57 children with viremia, including those at amino acid position 126, 127, 129, 131, 134, 143 or 144. There were no significant differences in the frequency of HBsAg mutation in relation to age, sex, and hepatitis B vaccination status of the children, suggesting that HBsAg mutation plays a limited role in failure of vaccination in Mongolia.

show abstract

High prevalence of hepatitis B, C and delta virus infections among blood donors in Mongolia

Cited by 34 publications

References 35 publications

Prevalence of infectious diseases among Mongolian blood donors

Prevalence of infectious diseases among Mongolian blood donors

Seroprevalence and risk factors for hepatitis B virus infection among general population in Northern India

Prevalence of hepatitis B, C, and delta virus infections among children in Mongolia: Progress in childhood immunization

Contact Info

Product

Resources

About