High prevalence of hantavirus infection in Indian communities of the Paraguayan and Argentinean Gran Chaco.

Ferrer, Jorge F.; Jonsson, Colleen B.; Esteban, Eduardo; Galligan, D.T.; Basombrío, Miguel Á.; Peralta-Ramos, Monica; Bharadwaj, Mausumi; Torrez‐Martinez, Norah; Callahan, John; Segovia, Amalia; Hjelle, Brian

doi:10.4269/ajtmh.1998.59.438

Cited by 73 publications

(52 citation statements)

References 25 publications

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“…The low seroprevalence of IgG antibodies in the Novo Progresso, Trairão and Guarantã do Norte (ranging from 2.16-4.75%) is in accordance with the data from Brazilian HPS cases (Holmes et al 2000, MS/SVS 2009, while in Marcelândia, the seroprevalence was similar to that observed in the Amazon area of MA (Mendes et al 2001(Mendes et al , 2010, as well as in Chile (Castillo et al 2002) and Paraguay (Ferrer et al 1998).…”

Section: Discussionsupporting

confidence: 75%

Circulation of hantaviruses in the influence area of the Cuiabá-Santarém Highway

Medeiros¹,

Rosa²,

Marques

et al. 2010

Mem. Inst. Oswaldo Cruz

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We describe evidence of circulation of hantaviruses in the influence area of the Santarém-Cuiabá Highway (BR-163) in the Brazilian Amazon through the prevalence of specific antibodies against hantaviruses in inhabitants living in four municipalities of this area: Novo Progresso (2.16%) and Trairão (4.37%), in state of Pará (PA), and Gua-rantã do Norte (4.74%) and Marcelândia (9.43%), in state of Mato Grosso. We also demonstrate the ongoing association between Castelo dos Sonhos virus (CASV) and hantavirus pulmonary syndrome (HPS) cases in the Castelo dos Sonhos district (municipality of Altamira, PA) and the first report of CASV in the municipalities of Novo Progresso and Guarantã do Norte. The results of this work highlight the risk for a possible increase in the number of HPS cases and the emergence of new hantavirus lineages associated with deforestation in this Amazonian area after the conclusion of paving works on BR-163 Highway

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Section: Discussionsupporting

confidence: 75%

Circulation of hantaviruses in the influence area of the Cuiabá-Santarém Highway

Medeiros¹,

Rosa²,

Marques

et al. 2010

Mem. Inst. Oswaldo Cruz

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“…8 Similar seroprevalence rates in Paraguay 9 and Brazil 10-12 may also be consistent with frequent mild disease that does not require hospitalization but may pose a significant economic burden. The identification of all HV infections will improve environmental risk assessments, public health intervention planning, and HV vaccine field evaluations.…”

Section: Discussionmentioning

confidence: 78%

“…4,6 A high prevalence of HV antibodies in serum, ranging from 12% to 45%, was noted in neighborhoods of HPS patients 3 and community-wide surveys 7,8 among individuals who had no history of hospitalization for respiratory insufficiency. A comparably high seroprevalence found in northern Argentina and Paraguay 9 and in Brazil [10][11][12] contrasts with low seroprevalence in Andes virus-endemic regions. 13,14 In four Panama communities, repeated seroprevalence surveys found that history-negative infections outnumbered hospitalized HPS in the same region by a ratio of 14:1.…”

Section: Introductionmentioning

confidence: 91%

Hantavirus Fever without Pulmonary Syndrome in Panama

Armién¹,

Pascale²,

Muñoz³

et al. 2013

The American Journal of Tropical Medicine and Hygiene

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Abstract. In Panama, hantavirus pulmonary syndrome (HPS) is caused by Choclo virus, a species phylogenetically related to Andes and Maporal viruses. Up to 60% of the population has been positive for specific serum antibody in community-based surveys, but mortality is very uncommon. In four western Panama clinics, we tested individuals presenting with a severe febrile prodrome for acute hantavirus (HV) infection by immunoglobulin M enzyme-linked immunosorbent assay and reverse transcription polymerase chain reaction as well as clinically similar infections, such as dengue and leptospirosis. From 2006 to 2009, at least 21% of 117 patients diagnosed with HV infection had HV Fever (HF) with no evidence of pulmonary edema (no respiratory distress or radiographic lung infiltrates), and 44% of patients had very mild HPS (radiographic pulmonary edema but no respiratory insufficiency). HV infection caused by Choclo virus in Panama presents often as HF, which contrasts with HV in the Americas but is consistent with the high seroprevalence in endemic regions.

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“…n the Americas, hantavirus species that occur at low frequency are associated with the severe disease hantavirus pulmonary syndrome (HPS) (1,2), and species that occur at higher frequency are associated with milder disease (3)(4)(5). In Panama, HPS is caused by the Choclo virus, for which a common rodent, the fulvous pygmy rice rat (6), is host.…”

mentioning

confidence: 99%