High prevalence of genetically diverse Borrelia bavariensis-like strains in Ixodes persulcatus from Selenge Aimag, Mongolia

Scholz, Holger C.; Margos, Gabriele; Derschum, Henri; Speck, Stephanie; Tserennorov, D.; Erdenebat, Nyamdorj; Undraa, B.; Enkhtuja, M.; Jigjav, Battsetseg; Otgonchimeg, C.; Otgonsuren, Gerechuluun; Nymadulam, B.; Römer, Angelika; Thomas, Ann; Eßbauer, Sandra; Wölfel, Roman; Kiefer, Daniel; Zöller, Lothar; Otgonbaatar, Dashdavaa; Fingerle, Volker

doi:10.1016/j.ttbdis.2012.08.004

Cited by 32 publications

(33 citation statements)

References 15 publications

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“…Phylogenetic analysis was conducted using maximum-likelihood (Tamura et al, 2011). Consistent with previous analyses (Margos et al, 2009;Scholz et al, 2013;Takano et al, 2011), European and Asian B. bavariensis sp. nov. formed a sister clade to B. garinii In this context, it is important to emphasize that giving species status to ecotypes of bacteria that form phylogenetically divergent sequence clusters (Koeppel et al, 2008) would have the advantage of being ecologically, epidemiologically and clinically predictive.…”

mentioning

confidence: 97%

Borrelia bavariensis sp. nov. is widely distributed in Europe and Asia

Margos

Wilske²,

Sing³

et al. 2013

International Journal of Systematic and Evolutionary Microbiology

105

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Since the original description of Borrelia bavariensis sp. nov. in 2009, additional samples available from humans and ticks from Europe and Mongolia, respectively, have been used to further characterize Borrelia strains belonging to this group of spirochaetes that utilize rodents as reservoir hosts. These investigations suggested the presence of related strains in Europe and Asia and confirmed their status as representing a distinct species. Furthermore, samples that were investigated by researchers from China and Japan confirm the ecological relationship of members of this proposed species with rodents and suggest that it has a wide distribution in Eurasia. Here, we use phylogenetic and genetic distance analyses to validate B. bavariensis sp. nov. as a species within the Borrelia burgdorferi sensu lato species complex. The type strain is PBiT ( = DSM 23469T = BAA-2496T).

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mentioning

confidence: 97%

Borrelia bavariensis sp. nov. is widely distributed in Europe and Asia

Margos

Wilske²,

Sing³

et al. 2013

International Journal of Systematic and Evolutionary Microbiology

105

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“…in I. pursulcatus ticks in Selenge aimag further providing evidence that rodents likely harbor Borrelia spp. in northern Mongolia [9,10]. While Dermacentor spp.…”

Section: Discussionmentioning

confidence: 99%

“…The most common strains of Borrelia spp. circulating in Mongolia are B. afzelii, B. bavariensis and B. garinii [9,10], all of which are reservoired in rodents and are commonly found to transmit to humans. B. garinii in particular has been identifed in hamster [13,27] and sibirian chipmunk species [26] in neighborhing China.…”

Section: Discussionmentioning

confidence: 99%

“…The few studies which have assessed this found Borrelia spp. in the general population with incidences as high as 7.8 cases per 100,000 persons per year in Selenge aimag [10] and seroprevalences of A. phagocytophilum ranging between 2.3 and 37.3% throughout the country [6,23]. Relatively less is known regarding the prevalence of SFGR in humans, however case studies have identified infections of Rickettsia siberica in international travelers visiting Mongolia and a recent study found high seroprevalences of SFGR among humans especially in the northern provinces of Mongolia [7,8,23].…”

Section: Discussionmentioning

confidence: 99%

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A cross-sectional study of small mammals for tick-borne pathogen infection in northern Mongolia

Pulscher

2018

Infection Ecology & Epidemiology

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Background: Tick-borne pathogens (TBPs) are frequently studied in developed nations but are often neglected in emerging countries. In Mongolia, TBP research is especially sparse, with few research reports focusing upon human and domestic animal disease and tick ecology. However, little information exists on TBPs in small mammals. Methods: In this 2016 cross-sectional pilot study, we sought to uniquely study wildlife for TBPs. We live-trapped small mammals, and tested their whole blood, serum and ear biopsy samples for molecular or serological evidence of Borrelia spp., Rickettsia spp., and Anaplasma spp./Ehrlichia spp. Results: Of 64 small mammals collected, 56.0%, 39.0% and 0.0% of animals were positive by molecular assays for Borrelia spp., Rickettsia spp., and Anaplasma spp./Erhlicia spp., respectively. 41.9% were seropositive for A. phagocytophilum and 24.2% of animals were seropositive for Rickettsia rickettsii. Conclusion: This pilot data demonstrates evidence of a number of TBPs among small mammal populations in northern Mongolia and suggests the need to further investigate what role these mammals play in human and domestic animal disease.

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“…Primary vectors for Rickettsiosis, Ehrlichiosis, Lyme disease and Q fever are arthropod ticks. Q fever, Lyme disease, zoonotic Ehrlichiosis and Rickettsiosis are the most detected zoonotic pathogens transmitted through tick engorgement in Mongolia, which makes the area as an endemic by these diseases [2,3,4,5,6]. Preventing tick infestation completely in free ranging livestock farming circumstances is barely impossible in today's condition in many countries around the world.…”

Section: Introductionmentioning

confidence: 99%