High prevalence of gastroesophageal reflux in patients with clinical unstable angina and known coronary artery disease

Schultz, Tomas; Mannheimer, Clas; Dellborg, Mikael; Pilhall, Martin; Börjesson, Mats

doi:10.1080/17482940701364877

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…Around 50% of patients with coronary artery disease (CAD) may suffer from coexisting gastroesophageal reflux (GERD) (18). Clinically it is very important to rule out/confirm the presence of myocardial ischemia in patients with chest pain of presumed cardiac origin, even in patients with established CAD.…”

Section: Clinical Aspects Of Visceral Painmentioning

confidence: 99%

Emerging therapies and novel approaches to visceral pain

Wesselmann

Baranowski

Börjesson

et al. 2009

Drug Discovery Today: Therapeutic Strategies

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Visceral pain is the most common type of pain associated with disease and it is one of the most frequent reasons why patients present to a doctor's office. Although these patients seek medical care because they are looking for help to alleviate their visceral discomfort and pain, in clinical practice much emphasis has been placed on finding a specific etiology and specific pathological markers for visceral disease. These patients typically undergo many diagnostic tests and procedures. However, often the examination and work-up remain unrevealing and no specific cause of the pain can be identified. In these cases it is important to recognize that pain is not only a symptom of visceral disease, but that the patient is suffering from a "chronic visceral pain syndrome".Although visceral pain is very common, the recognition of chronic visceral pain as a chronic pain syndrome is fairly new in the clinical subspecialties of gynecology, urology, gastroenterology and cardiology. Much of what we know about the pathophysiological mechanisms of pain is derived from experimental studies of somatic and not visceral

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Section: Clinical Aspects Of Visceral Painmentioning

confidence: 99%

Emerging therapies and novel approaches to visceral pain

Wesselmann

Baranowski

Börjesson

et al. 2009

Drug Discovery Today: Therapeutic Strategies

Self Cite

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“…Therefore GERD may be misclassified as ischemic heart disease (IHD) and vice versa [12] . Moreover GERD is rather common among patients with IHD, especially those with unstable angina [13] . Circulating angiogenetic markers are increased in patients with IHD especially those with myocardial infarction (MI) [14] or severe congestive heart failure [15] .…”

Section: Introductionmentioning

confidence: 99%

Ischemic heart disease, factor predisposing to Barrett’s adenocarcinoma: A case control study

Tsibouris

Hendrickse

Mavrogianni

et al. 2014

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AIM:To define the significance of ischemic heart disease (IHD) (stable angina to infarction) co-existance in Barrett esophagus (BE) patients and patients with esophageal adenocarcinoma (AdE). METHODS:All BE/AdE patients in Blackpool-WyreFylde area and Trikala prefecture identified from medical records. Patient clinical details were obtained from hospital and General Practitioner records. Additional information was gathered from validated questionnaire. RESULTS:Forty (33%) AdE and 83 (19%) BE patients had IHD (P = 0.002). Eighteen (15%) AdE and 34 (8%) BE patients had suffered a myocardial infarction (P = 0.03). Three (3%) AdE and 7 (2%) BE patients had severe heart failure (P = 0.82). Thirty-nine (47%) BE with IHD and 8 (20%) AdE patients with IHD consumed aspirin daily (P = 0.004). Seventh-seven (93%) BE patients with IHD and 36 (90%) AdE patients with IHD were on statins (P = 0.86). Logistic regression analysis: AdE was more frequent in the elderly, with long term reflux, long BE and concurrent IHD (odds ratio: 2.086, P = 0.001) not consuming statins. Eighteen (22%) BE patients with IHD [16 (84%) with myocardial infarction] vs 33 (10%) without IHD died from non-neoplastic causes within 24 mo from BE diagnosis (P = 0.005). CONCLUSION:IHD is more prevalent in AdE than BE patients. Increased prevalence of AdE is related with the presence of myocardial infarction but not severe heart failure, possibly because patients with BE and severe IHD have low life expectancy.

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“…The original publication by Schultz et al (5) show that esophageal reflux is common in patients with coronary artery disease and therefore, it is clinically important that gastroesophageal examination in patients presented with unstable angina is considered. Zeymer et al (6) have emphasized once again the importance of early therapy with clopidogrel in patients with non-ST elevation MI and have shown a significant reduction in major clinical events at a cost of an increase in major in-hospital bleeding complications.…”

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confidence: 99%