High prevalence of Demodex spp. infestation among patients with posterior blepharitis: Correlation with age and cylindrical dandruff

López-Ponce, D.; Zuazo, Francisca; Cartes, Cristián; Salinas-Toro, Daniela; Pérez-Valenzuela, C.; Valenzuela, Felipe; Traipe-Castro, Leonidas; López‐Solís, Remigio

doi:10.1016/j.oftale.2017.07.002

Cited by 17 publications

(16 citation statements)

References 23 publications

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“…This high prevalence is consistent with the results of studies by de Venecia et al and Bhandari et al, who reported a prevalence of 73% and 68%, respectively, for Demodex (17,18). However, some studies reported values as low as 41, 27.4, and 26.1% (7,8,19).…”

Section: Discussionsupporting

confidence: 92%

“…Several studies aimed to answer this question; however, the literature evidence is controversial. Some studies have pointed to Demodex as the possible cause of blepharitis by showing a high prevalence of concomitance of these two conditions (6), while others found no difference in Demodex prevalence between blepharitis and nonblepharitis cases (7)(8)(9). modex by various mechanisms, including mechanical blockage and reactive hyper keratinization, granulomatous reaction, delayed hypersensitivity, and vector role for bacteria (4).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Demodex in Association with Ocular Signs and Symptoms: Evidence from a Large Population of Male Soldiers Living in Garrison

Fatourechi

Fakhri

Shirzad

et al. 2021

Ann Mil Health Sci Res

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Background: The Demodex mite is the most common ectoparasite on human skin. It’s a matter of debate whether this colonization should be an area of concern and can cause pathologic consequences or, in contrast, Demodex should merely be considered as an innocent saprophytic organism living on the skin. Objectives: We aimed to evaluate the prevalence of ocular Demodex infestation in a large population of male soldiers with a similar range of age, in whom we expected a high transmission rate due to environmental factors and close contacts. Besides, we evaluated the correlation between Demodex and ocular clinical manifestations. Methods: In total 903 soldiers living on a military base in Iran were enrolled in this epidemiological cross-sectional prevalence study conducted in the summer of 2020. Data were collected using a questionnaire on ocular symptoms, and participants were assessed for the presence of Demodex spp. Results: A total of 904 males with a mean age of 21 ± 2 years (ranging from 19 to 25) were included. The overall prevalence of Demodex infestation was 77.2% (86.8 and 26% in patients with and without blepharitis, respectively). Of 698 patients who were positive for Demodex, 58.6% reported eye discomfort, whereas it was experienced by 23.9% of Demodex negative participants, the difference was statistically significant (P-value < 0.001). Conclusions: There is a strong association between the prevalence of Demodex spp. and symptoms, in particular itchy eyes. However, some patients are asymptomatic. This finding supports the notion that the number of mites may be important concerning the manifestation of clinical signs of blepharitis; however, the role of Demodex spp., as a commensal, should not be overlooked. Treatment should not be aimed at full eradication of the mite but rather restoring the ocular ecology to a balanced state.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Prevalence of Demodex in Association with Ocular Signs and Symptoms: Evidence from a Large Population of Male Soldiers Living in Garrison

Fatourechi

Fakhri

Shirzad

et al. 2021

Ann Mil Health Sci Res

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“…Investigators propose that DF has symbiotic relationship with humans and is bene cial as it ingests bacteria in the follicular canal [6] .It was reported that the prevalence of DF infection increases with age [15] . The positive rate of the population at age 60 years was showed to be 84%, and 100% in those older than 70 years [16] . Infection in children under 10 years of age is rare [17] .…”

Section: Introductionmentioning

confidence: 92%

The Prevalence of Ocular Demodex folliculorum in 2253 Young Males The Prevalence of Ocular Demodex folliculorum

Wang

Yan

et al. 2021

Preprint

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AimTo determine the prevalence and influencing factors of Demodex folliculorum (DF) in the eyelashes of healthy young males.MethodsAn epidemiological cross-sectional prevalence study was conducted. A total of 2253 healthy young males (aged 17-24 years) were studied for the presence of DF within eyelash follicles. The presence of DF was analyzed according to various factors.ResultsThe total prevalence of DF was 20.73% in our study. Subjects with history of myopia correction surgery had a statistically significant increase in the positive rate of DF (P<0.001). The positive rate was higher in subjects with ocular symptoms than in those without symptoms (P<0.05). Factors such as the educational level, long-term residence, annual household income, sleep time, time of using electronic products, smoke and drinking habits, had no significant correlation with the DF positive rate (all P>0.05). According to the multivariate logistic regression analysis, the history of myopic correction surgery was the risk factors of DF infection (P<0.001). There was no correlation between ocular discomfort and DF infection (P>0.05).ConclusionsThe prevalence of DF in eyelash follicles in healthy young men was relatively high. The history of myopic correction surgery was an important risk factor for the infection.

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“…68 Lashes with CDs are far more likely to have mites than those without. 39,66,69 Follicular distension and hypertrophy may be observed at the opening of the follicle as a result of the consummation of epithelial cells, coupled with the fact that a cluster of mites may be cohabitating in a single follicle. 46,70 Loose lashes, lash loss (milphosis) and misdirected lashes (trichiasis) may result as nutrients and structure of the follicles become affected by Demodex infestation.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Although Demodex infestation can present with little to no symptoms, there are co-morbidities that have been associated with its presence, such as blepharitis, 49,[72][73][74] meibomian gland dysfunction (MGD), 69,72,75,76 keratitis, 72,77 blepharokeratoconjunctivitis, 56 chalazion, 55,72,78 dry eye, 79 and pterygium. 80 The risk of Demodex in patients with blepharitis is 2.5-fold, while the risk in rosacea patients is threefold higher than in the general population.…”

Section: Demodex and Eye Diseasementioning

confidence: 99%

Demodex and eye disease

Bitton

Aumond

2021

Clinical and Experimental Optometry

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Demodex is the most common parasite living on humans and yet little is understood about its pathogenicity with respect to the ocular surface. An increasing interest in Demodex over the past 20years has increased our understanding of this mite and its pathogenetic role. This article begins with a review of the anatomy, life cycle, mode of transmission and advances in genetics that can distinguish between Demodex folliculorum and Demodex brevis, the only two Demodex species in humans. Additionally, a review of diagnostic procedures and existing and emerging ocular and systemic management options are presented. Despite the increasing interest in Demodex in the literature, there remains numerous obstacles for future studies, hence a section of this review is dedicated to the identification and proposal for future considerations. The lack of uniformity with respect to terminology, diagnostic technique and management approach for Demodex remain as obstacles for future study comparisons. This review summarised the current knowledge on Demodex and hopes to offer some recommendations for future directions in the study of Demodex in humans.

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High prevalence of Demodex spp. infestation among patients with posterior blepharitis: Correlation with age and cylindrical dandruff

Cited by 17 publications

References 23 publications

Prevalence of Demodex in Association with Ocular Signs and Symptoms: Evidence from a Large Population of Male Soldiers Living in Garrison

Prevalence of Demodex in Association with Ocular Signs and Symptoms: Evidence from a Large Population of Male Soldiers Living in Garrison

The Prevalence of Ocular Demodex folliculorum in 2253 Young Males The Prevalence of Ocular Demodex folliculorum

Demodex and eye disease

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