High prevalence of congenital hypothyroidism in Isfahan: Do familial components have a role?

Hashemipour, Mahin; Hovsepian, Silva; Kelishadi, Roya

doi:10.4103/2277-9175.100130

Cited by 11 publications

(10 citation statements)

References 32 publications

(37 reference statements)

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“…Previous studies showed that CH patients had larger head circumference especially those with thyroid agenesis, which reached normal value by treatment [38, 39]. In contrast to other studies [38], in the current survey, the head circumference was lower than normal value, and it may be due to that the majority of CH patients in Isfahan were dyshormonogenetic ones [40], or it may be due to proper and early treatment. However it needs more studies for more accurate conclusion.…”

Section: Discussioncontrasting

confidence: 82%

Growth and Specialized Growth Charts of Children with Congenital Hypothyroidism Detected by Neonatal Screening in Isfahan, Iran

et al. 2013

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Objectives. The aim of the current study was to investigate the growth status of CH, generate specialized growth charts of CH infants, and compare them with their counterparts of regional normal infants. Methods. In this prospective cohort study, 760 (345 girls and 415 boys) neonates born in 2002–2009 diagnosed by neonatal CH screening program in Isfahan were followed up from the time of diagnosis. 552 healthy children were recruited as a control group. The empirical 3rd, 15th, 50th, 85th, and 97th percentiles for height, weight, and head circumference of both sexes were determined and compared with their counterpart values of the control group. The relative frequency of patients with impaired growth for each studied variable was determined. Also, specialized growth charts of CH patients were generated. Results. The percentiles of weight, height, and head circumference of studied patients are significantly different from regional healthy children (P < 0.001). The relative frequency of impaired head circumference was decreased to less than 3% at the 3rd year of age and for height it reached gradually 3% and 9% at the 5th year of age for boys and girls, respectively (P < 0.05); however for weight still it was statistically more than 3% in both sexes. Conclusion. CH patients had impaired growth development which was improved during follow up, but the catch-up time was earlier for head circumference and later for weight.

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Section: Discussioncontrasting

confidence: 82%

Growth and Specialized Growth Charts of Children with Congenital Hypothyroidism Detected by Neonatal Screening in Isfahan, Iran

et al. 2013

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“…The confirmed CH incidence is 1/1694 in this population. It is known that the incidence of CH could vary significantly from one ethnic group to another (1/370 ( 17 ) to 1/10,000 ( 18 )). Currently, the overall incidence of CH in Chinese population is not known, two previous studies based on populations in Zhejiang and Shanghai provided the incidences for Han Chinese as 1:1678 and 1:3009, respectively.…”

Section: Discussionmentioning

confidence: 99%

The incidence of congenital hypothyroidism (CH) in Guangxi, China and the predictors of permanent and transient CH

Luo

et al. 2017

Endocrine Connections

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BackgroundThe incidence of congenital hypothyroidism (CH) differs significantly among different ethnicities and regions, and early differentiation of transient CH is important to avoid unnecessary prolonged treatment with L-T4.ObjectiveTo investigate the incidence of CH based on the newborn screening program in Guangxi Zhuang Autonomous Region, China, and to analyze the predictors that might allow for an early differentiation between permanent (P) and transient (T) CH.Design and methodsData from newborn screening program over a seven-year period (January 2009 to January 2016) at Guangxi Maternal and Child Health Hospital are analyzed. Blood samples were collected on filter paper between 3 and 7 days after birth, and TSH level was measured by time-resolved fluorescence assay. Individuals with increased TSH (TSH ≥ 8 IU/L) levels detected by newborn screening were recalled for further evaluation. Serum TSH, FT3 and FT4 were determined by electrochemiluminescence assay using venous blood samples. Diagnosis of CH is based on elevated TSH levels (>10 IU/L) and decreased FT4 levels (<12 pmol/L). Patients with elevated TSH levels and normal FT4 levels were diagnosed as hyperthyrotropinemia. Permanent or transient CH was determined by using the results of thyroid function tests after temporary withdrawal of L-T4 therapy at approximately 2–3 years of age.ResultsAmong 1,238,340 infants in the newborn screening program, 14,443 individuals were recalled for reevaluation (re-call rate 1.18%), 911 and 731 individuals were subsequently determined to have hyperthyrotropinemia and CH respectively; thus, a prevalence of 1:1359 and 1:1694 for hyperthyrotropinemia and CH. Of the 731 patients with CH, 161 patients were diagnosed with permanent CH (PCH), and 159 patients were diagnosed with transient CH (TCH), the other 411 patients are too young to determine their subtypes. Patients with PCH required an increasing dose of L-T4 during the first few years, whereas patients with TCH required a decreased dose of L-T4. The TSH levels at diagnosis and the dose of L-T4 used were significantly higher in PCH cases than in transient cases. The FT4 levels at diagnosis were significantly lower in PCH cases than in TCH cases. The TSH levels at diagnosis, FT4 levels at diagnosis and L-T4 doses at 90 days were evaluated as predictors for differentiating PCH and TCH, and their accuracy at their respective optimal cutoffs were determined to be 60.6%, 66.7% and 93.9%, respectively.ConclusionsThe CH incidence in Guangxi Zhuang Autonomous Region is slightly higher (1:1694) compared to the worldwide levels (1/2000–1/4000). The PCH and TCH ratio is close to 1; thus, the estimated PCH incidence is 1/3388, which is similar to reported worldwide average incidence (1/3000). The L-T4 dose required at 90 days (>30 μg/day) has the highest predictive value for PCH. Earlier differentiation of PCH and TCH helps to determine appropriate treatment course.

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“…The first screening for CH in in Markazi Province was performed in 2006. According to the national screening program, the prevalence of CH in Iran is higher than global statistics and different prevalence figures are reported in different provinces ( 5 , 6 , 9 , 10 , 11 ).…”

Section: Introductionmentioning

confidence: 95%

“…The first screening programs for CH were conducted in North America in 1972 ( 4 ). Studies have suggested that the prevalence of CH appears to be on the increase in many countries due to many factors such as diagnosis of mild cases, increasing maternal age, increasing premature birth, multiple pregnancies and lower cut-off point ( 1 , 5 , 6 , 7 ). In Iran, screening programs for CH were first carried out by Azizi et al ( 8 ) in Tehran in 1987.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Congenital Hypothyroidism in Markazi Province, Iran

Dorreh¹,

Chaijan²,

Javaheri³

et al. 2014

Jcrpe

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Objective: The aim of this study was to investigate the epidemiology of congenital hypothyroidism (CH) among newborns in Markazi Province, Iran.Methods: This cross-sectional study was conducted from 2006 to 2012. Blood samples were taken between 3 to 5 days after birth from the heel. Thyroid stimulating hormone (TSH) was tested using the enzyme-linked immunosorbent assay method and was employed as the screening test. Newborns with abnormal screening results (TSH >5 mIU/L) were re-examined. The data were analyzed using SPSS.Results: A total of 127 112 infants were screened. Of these, 51.2% were male and 48.8% were female. The coverage rate of the screening program was 100%. Of 6102 recalled subjects (re-call rate 4.8%), 414 cases with CH were detected, yielding a CH prevalence of 1:307 (female:male ratio 1:0.95). The prevalence of permanent and transient CH was 1:581 and 1:628, respectively.Conclusion: This study reveals that the prevalence of CH is higher compared to worldwide levels. Comprehensive and complementary studies for recognizing related risk factors should be a priority for health system research in this province.

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High prevalence of congenital hypothyroidism in Isfahan: Do familial components have a role?

Cited by 11 publications

References 32 publications

Growth and Specialized Growth Charts of Children with Congenital Hypothyroidism Detected by Neonatal Screening in Isfahan, Iran

Growth and Specialized Growth Charts of Children with Congenital Hypothyroidism Detected by Neonatal Screening in Isfahan, Iran

The incidence of congenital hypothyroidism (CH) in Guangxi, China and the predictors of permanent and transient CH

Epidemiology of Congenital Hypothyroidism in Markazi Province, Iran

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