High prevalence of coeliac disease in siblings of children with type 1 diabetes

Šumnı́k, Zdenĕk; Koloušková, Stanislava; Malcová, Hana; Vavřinec, J; Venhácová, J; Lebl, Jan; Cinek, Ondřej

doi:10.1007/s00431-004-1547-1

Cited by 15 publications

(11 citation statements)

References 19 publications

(23 reference statements)

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“…The first study conducted by Hummel et al (6) showed the frequent occurrence of CD-associated antibodies in relatives. Consecutive studies have yielded similar results in that increased prevalence of biopsy-proven or serology-positive CD was found in relatives of diabetics (6,8,(10)(11)(12). Conversely, Saukkonen et al (9) reported similar prevalence of biopsy-proven CD and Jaeger et al (7) reported similar rates of seropositivity of IgAtTG positivity between first-degree relatives of T1DM and control groups, similar to our results.…”

Section: Statistical Analysessupporting

confidence: 80%

Prevalence of Celiac disease in Turkish children with type 1 Diabetes Mellitus and their non-diabetic first-degree relatives

Sarı

Yeşilkaya²,

Eğritaş³

et al. 2010

Turk J Gastroenterol

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Section: Statistical Analysessupporting

confidence: 80%

Prevalence of Celiac disease in Turkish children with type 1 Diabetes Mellitus and their non-diabetic first-degree relatives

Sarı

Yeşilkaya²,

Eğritaş³

et al. 2010

Turk J Gastroenterol

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“…This pattern is reminiscent of celiac disease (CD), an autoimmune disorder triggered by the ingestion of gluten in susceptible individuals. Overlap between both diseases has long been acknowledged, and the prevalence of (undiagnosed) CD within T1D and their relatives is higher than expected (199,313,414). Unlike in CD patients, however, there is no robust evidence to assume that gluten actually drives the initiation of autoimmunity in T1D (198).…”

Section: Wheat Proteinsmentioning

confidence: 97%

Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies

Belle

Coppieters

Herrath

2011

Physiological Reviews

858

695

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Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We only know for sure that autoimmunity is the predominant effector mechanism of T1D, but may not be its primary cause. T1D precipitates in genetically susceptible individuals, very likely as a result of an environmental trigger. Current genetic data point towards the following genes as susceptibility genes: HLA, insulin, PTPN22, IL2Ra, and CTLA4. Epidemiological and other studies suggest a triggering role for enteroviruses, while other microorganisms might provide protection. Efficacious prevention of T1D will require detection of the earliest events in the process. So far, autoantibodies are most widely used as serum biomarker, but T-cell readouts and metabolome studies might strengthen and bring forward diagnosis. Current preventive clinical trials mostly focus on environmental triggers. Therapeutic trials test the efficacy of antigen-specific and antigen-nonspecific immune interventions, but also include restoration of the affected beta-cell mass by islet transplantation, neogenesis and regeneration, and combinations thereof. In this comprehensive review, we explain the genetic, environmental, and immunological data underlying the prevention and intervention strategies to constrain T1D.

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“…In association with various autoimmune disorders, wheat proteins and, more specifically, gluten, have received significant attention [98–100]. Indeed, it has been demonstrated that a wheat-based diet induces not only Th1-type cytokine bias in the gut but also increased T-cell reactivity to gluten, with a higher frequency of diabetes [99–101]. In addition to diabetes, it has been shown that celiac disease (CD) is associated with various extraintestinal autoimmune disorders that involve the thyroid, joints, heart, skin, pancreas, bone, liver, reproductive organs, and the nervous system [102–112].…”

Section: Dietary Components and Autoimmunitiesmentioning

confidence: 99%

A Potential Link between Environmental Triggers and Autoimmunity

Vojdani

2014

Autoimmune Diseases

114

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Autoimmune diseases have registered an alarming rise worldwide in recent years. Accumulated evidence indicates that the immune system's ability to distinguish self from nonself is negatively impacted by genetic factors and environmental triggers. Genetics is certainly a factor, but since it normally takes a very long time for the human genetic pattern to change enough to register on a worldwide scale, increasingly the attention of studies has been focused on the environmental factors of a rapidly changing and evolving civilization. New technology, new industries, new inventions, new chemicals and drugs, and new foods and diets are constantly and rapidly being introduced in this fast-paced ever-changing world. Toxicants, infections, epitope spreading, dysfunctions of immune homeostasis, and dietary components can all have an impact on the body's delicate immune recognition system. Although the precise etiology and pathogenesis of many autoimmune diseases are still unknown, it would appear from the collated studies that there are common mechanisms in the immunopathogenesis of multiple autoimmune reactivities. Of particular interest is the citrullination of host proteins and their conversion to autoantigens by the aforementioned environmental triggers. The identification of these specific triggers of autoimmune reactivity is essential then for the development of new therapies for autoimmune diseases.

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High prevalence of coeliac disease in siblings of children with type 1 diabetes

Abstract: The 3.8% frequency of coeliac disease found in siblings of diabetic children is close to the 4.3% found previously in Czech children with type 1 diabetes mellitus and is substantially higher than the rate in the healthy children population.

Cited by 15 publications

References 19 publications

Prevalence of Celiac disease in Turkish children with type 1 Diabetes Mellitus and their non-diabetic first-degree relatives

Prevalence of Celiac disease in Turkish children with type 1 Diabetes Mellitus and their non-diabetic first-degree relatives

Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies

A Potential Link between Environmental Triggers and Autoimmunity

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