High prevalence of clindamycin resistance in Staphylococcus aureus blood culture isolates in São Paulo, Brazil

Lupinacci, Felipe S; Bussius, Daniel; Acquesta, Felipe; Fam, Gustavo; R, Rossi; Navarini, Alessandra; Mimica, Marcelo Jenne

doi:10.4103/jlp.jlp_161_16

Cited by 4 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 Clindamycin is an important antimicrobial alternative for the cure of Staphylococcus aureus infection. 3 This antibiotic has been used as empiric therapy for the intensifying incidence of both hospital and community-acquired methicillin-resistant S.…”

Section: Introductionmentioning

confidence: 99%

D-Test as a tool to detect the frequency of clindamycin resistance in community acquired and hospital acquired methicillin resistant Staphylococcus aureus infections (MRSA).

Razzak¹,

Faisal

Detho

et al. 2020

TPMJ

View full text Add to dashboard Cite

Objectives: D-Test as a tool to detect the frequency of clindamycin resistance in community acquired and hospital acquired methicillin resistant Staphylococcus aureus infections. Study Design: A cross-sectional study. Setting: Microbiology department of BMSI, JPMC, Karachi. Period: January 2015 till December 2015. Material & Methods: Pus samples from deep wounds, skin lesions, abscesses, postoperative wounds from surgical, medical wards and OPDs were collected. MRSA testing and susceptibility testing for antibiotics was done according to CLSI2014. The frequency of inducible clindamycin resistance was detected by D-Test of the CA-MRSA and HA-MRSA. Result: In a total of 402 S. aurous isolates, 253 (62.93%) were methicillin-sensitive and 149 (37.06%) were methicillin-resistant. Out of 149 MRSA, 106 (71.14%) were HA-MRSA and 43(28.85%) were CA-MRSA. Among the HA-MRSA, 63(59.8%) were resistant to clindamycin while with D-Test, it increased to 78(73.58%). Out of 43 CA-MRSA, 9 (21.6%) were clindamycin resistant, while with D-Test, the resistance to clindamycin increased to 13 (30.23%). Conclusion: Inducible clindamycin-resistant strains may lead to clindamycin treatment failure in patients with S. aureus infection. Therefore, D-test should be done in priority to detect inducible clindamycin resistance in S. aurous.

show abstract

Section: Introductionmentioning

confidence: 99%

D-Test as a tool to detect the frequency of clindamycin resistance in community acquired and hospital acquired methicillin resistant Staphylococcus aureus infections (MRSA).

Razzak¹,

Faisal

Detho

et al. 2020

TPMJ

View full text Add to dashboard Cite

show abstract

The History of Methicillin-Resistant Staphylococcus aureus in Brazil

Andrade

Luiz

Souza

et al. 2020

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

Since the emergence of MRSA in the 1960s, a gradual increase in infections by resistant bacteria has been observed. Clinical manifestations may vary from brand to critical condition due to host risk factors, as well as pathogen virulence and resistance. The high adaptability and pathogenic profile of MRSA clones contributed to its spread in hospital and community settings. In Brazil, the first MRSA isolates were reported in the late 1980s, and since then different genetic profiles, such as the Brazilian epidemic clone (BEC) and other clones considered a pandemic, became endemic in the Brazilian population. Additionally, Brazil’s MRSA clones were shown to be able to transfer genes involved in multidrug resistance and enhanced pathogenic properties. These events contributed to the rise of highly resistant and pathogenic MRSA. In this review, we present the main events which compose the history of MRSA in Brazil, including numbers and locations of isolation, as well as types of staphylococcal cassette chromosome mec (SCCmec) found in the Brazilian territory.

show abstract

Staphylococcus aureus

Ondusko¹,

Nolt

2018

Pediatrics in Review

View full text Add to dashboard Cite

is a bacterium that can cause a variety of illnesses through suppurative or nonsuppurative (toxin-mediated) means. is a common cause of skin and skin structure infections as well as osteoarticular infections in the pediatric population. is also identified in cases of septicemia, infective endocarditis, pneumonia, ocular infections, and central nervous system infections. To design appropriate empirical therapy, pediatricians should be knowledgeable about the resistance patterns of in their communities, including methicillin and clindamycin resistance. This article reviews the microbiology, colonization and transmission, and antibiotic resistance of and clinical diseases caused by

show abstract

High prevalence of clindamycin resistance in Staphylococcus aureus blood culture isolates in São Paulo, Brazil

Cited by 4 publications

References 9 publications

D-Test as a tool to detect the frequency of clindamycin resistance in community acquired and hospital acquired methicillin resistant Staphylococcus aureus infections (MRSA).

D-Test as a tool to detect the frequency of clindamycin resistance in community acquired and hospital acquired methicillin resistant Staphylococcus aureus infections (MRSA).

The History of Methicillin-Resistant Staphylococcus aureus in Brazil

Staphylococcus aureus

Contact Info

Product

Resources

About