High prevalence of chronic kidney disease in population-based patients diagnosed with type 2 diabetes in downtown Shanghai

Lü, Bin; Song, Xiaoyan; Dong, Xuehong; Yang, Yehong; Zhang, Zhaoyun; Wen, Jie; Li, Yiming; Zhou, Lei; Zhao, Ning; Zhu, Xiangjia; Hu, Renming

doi:10.1016/j.jdiacomp.2007.08.001

Cited by 56 publications

(40 citation statements)

References 40 publications

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“…The present study showed that a longer duration of T2DM and older age were associated with a higher prevalence of all complications and comorbidities, which is consistent with previous studies [21,22]. In addition, patients with a family history were significantly correlated with diabetes and its complications (e.g., diabetic lower limb vascular disease and diabetic peripheral neuropathy), in agreement with other studies [23,24].…”

Section: Discussionsupporting

confidence: 93%

Latent class analysis suggests four classes of persons with type 2 diabetes mellitus based on complications and comorbidities in Tianjin, China: a cross-sectional analysis

et al. 2017

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Section: Discussionsupporting

confidence: 93%

Latent class analysis suggests four classes of persons with type 2 diabetes mellitus based on complications and comorbidities in Tianjin, China: a cross-sectional analysis

et al. 2017

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“…It should also be noted that the larger proportion of participants with CKD was due to albuminuria, and the prevalence of reduced GFR was less than that reported in the study among patients in UK general practices (18). The association between duration of diabetes and CKD has been reported in other studies (16,17,20) and is generally consistent with the pathophysiology of diabetes complications. The lack of an association with age was probably due to the small size of the study and the high overall prevalence of proteinuria.…”

Section: Discussionsupporting

confidence: 78%

“…For example, a study among diabetic patients in primary care practices in Spain reported a CKD prevalence of 27.9%, but while these patients were older than those in this study, the mean duration of diabetes was only nine years compared to 17 years in this study (14). One study among urban community-based participants in China reported a CKD prevalence of 29.6% (15), but another study among participants over 30 years old from 'downtown Shanghai' reported a CKD prevalence of 63.9% (16). Additionally, one study from the United Kingdom (UK) reported a prevalence of clinically significant CKD (stage 3-5 based on eGFR) of 31.3%, while another study among Canadian First Nation adults reported a prevalence of (19).…”

Section: Discussioncontrasting

confidence: 69%

Prevalence of Chronic Kidney Disease among Patients Attending a Specialist Diabetes Clinic in Jamaica

Younger-Coleman

et al. 2015

West Indian Med J

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“…A similar study from Bangladesh also found no significant correlation between duration of T2DM (< 5 years or 5-10 years) and renal function parameters (serum creatinine, ACR, eGFR,) [28]. However, a Chinese study revealed significant association of CKD with duration of diabetes [29].…”

Section: Medical History N (%) Duration In Monthsmentioning

confidence: 89%

Prevalence of Chronic Kidney Disease (CKD) in Type 2 Diabetes Mellitus Patients: START-India Study

Rajput¹,

Kumar²,

Seshadri³

et al. 2017

J Diabetes Metab

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Objective: Despite rising incidence of diabetes in India, we currently lack country wide data on the prevalence of CKD in T2DM patients. Hence this nationwide study was planned.Methods: This was a nationwide, cross-sectional, observational, multi-centric study to assess prevalence of CKD among T2DM patients. The primary endpoint of the study was to estimate proportion of T2DM patients with CKD (glomerular filtration rate [GFR] <60 ml/min/1.73 m 2 or albumin creatinine ratio [ACR] ≥ 30 mg/g or ≥ 3 mg/mmol or both). The blood/plasma and urine samples, were collected for estimation of hemoglobin A1c, microalbuminuria, serum creatinine, urine creatinine, and routine urine analysis.Results: Of the 3043 screened subjects, 3000 eligible subjects were enrolled, out of which 46% were females. The mean age was 53.4 (± 11.9) years, with a mean body mass index of 27.3 (± 4.8) kg/m 2 . Both micro and macro vascular complications were reported. In the studied population with T2DM, 47.8% had mildly decreased, 15.1% had mild to moderately decreased, and 1.8% had severely decreased GFR respectively. As per ACR categorization, 61.3% had normal to mildly increased ACR, 25.6% with moderately increased and 7.2% with severely increased ACR were seen. We observed a significant (p<0.0001) weak negative correlation (-0.23069) between eGFR< 60 mL/ min/1.73 m² and urinary ACR in over six hundred patients. We found 48.4% prevalence of CKD in T2DM patients. The results on analysis of HbA1c goal achievement showed that the patients without CKD had a better success rate to achieve the target <7% goal of HbA1c compared to those who had CKD (29.6% vs. 23.4%). Conclusion:Study reported higher prevalence of CKD which was driven by the ACR levels and majority of the patients had reasonable eGFR. This can be a guide to select drug and dosage of diabetes drug as it depends on kidney function.

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High prevalence of chronic kidney disease in population-based patients diagnosed with type 2 diabetes in downtown Shanghai

Cited by 56 publications

References 40 publications

Latent class analysis suggests four classes of persons with type 2 diabetes mellitus based on complications and comorbidities in Tianjin, China: a cross-sectional analysis

Latent class analysis suggests four classes of persons with type 2 diabetes mellitus based on complications and comorbidities in Tianjin, China: a cross-sectional analysis

Prevalence of Chronic Kidney Disease among Patients Attending a Specialist Diabetes Clinic in Jamaica

Prevalence of Chronic Kidney Disease (CKD) in Type 2 Diabetes Mellitus Patients: START-India Study

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