High Prevalence of Cervical Intraepithelial Neoplasia 2/3 Among Adolescents Discovered with Biopsy at Time of Incident Colposcopic Evaluation

Moore, Kathleen N.; Cofer, Amanda; Elliot, L.; Lanneau, Grainger S.; Downing, Kim; Walker, JL; Gold, M.A.

doi:10.1097/00128360-200607000-00039

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is ongoing debate suggesting that adolescent dysplasia often follows a transient course, proposing that a more conservative approach might be su cient in management. However, the signi cant presence of CIN-2 + in the adolescent cohort of this study indicates that dysplasia in this age group is not an insigni cant nding and thus requires vigilant monitoring and management [15]. Lörincz and colleagues have demonstrated that the combination of HPV DNA testing and Papanicolaou (Pap) cytology screening offers nearly 100% sensitivity and negative predictive value for detecting HGSIL.This highlights the potential utility of this combined screening strategy for optimizing cervical cancer prevention programs.…”

Section: Discussionmentioning

confidence: 66%

See 1 more Smart Citation

Colposcopic Biopsy Findings in ASCUS or Normal Cervical Cytology Patients with High-Risk HPV Positivity

Erdoğan,

Kasap,

Ozdaş

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: The aim of the present study was to compare colposcopic biopsy results of women in Turkey with normal cervical cytology and Atypical Squamous Cells of Undetermined Significance(ASCUS) who had human papilloma virüs(HPV) genotypes 16,18,and combined 16/18.The overarching goal was to enhance the existing body of evidence on cervical cancer screening strategies, with an ultimate aim of refining HPV testing guidelines and improving patient management. Methods:In this retrospective study, we examined the medical records of 1121 patients from a tertiary health care setting who tested positive for HPV 16,HPV 18, or both, and who exhibited ASCUS or normal Pap smear findings. A detailed review of the patients' colposcopic biopsy outcomes was conducted, with particular attention to their HPV genotype status and the impact of smoking. Results: Study involved 1121 patients , the participants were classified based on HPV genotype into three groups: HPV 16 (78.5%), HPV 18 (15.8%),and co-infection with HPV 16 & 18 (5.7%). On the basis of smear characteristics, patients were categorized as normal (81.4%) and ASCUS (18.2%). Notably, for those with normal smear results, the rate of CIN-1 biopsy was approximately 15% higher in the HPV-18 group than the HPV-16 group (59.6% vs. 45.8%; p=0.023).Smoking prevalence was significantly higher in the co-infected HPV 16/18 group (p=0.013). Conclusion:This study underscores the importance of vigilant HPV and cytology testing, especially for individuals with HPV 16/18, regardless of normal cytology findings.

show abstract

Section: Discussionmentioning

confidence: 66%

“…The natural history of HPV infection is complex. Some individuals can clear the infection, while in others, it can persist and potentially lead to precancerous lesions and, eventually, invasive cancer [12,15,19]. Particularly in the case of high-risk HPV types like HPV 16 and 18, the risk of progression is signi cantly higher [1,3,14].…”

Section: Discussionmentioning

confidence: 99%