High prevalence of Babesia microti ‘Munich’ type in small mammals from an Ixodes persulcatus/Ixodes trianguliceps sympatric area in the Omsk region, Russia

Рар, В. А.; Yakimenko, V. V.; Makenov, Marat T.; Tikunov, Artem; Epikhina, Tamara; Tancev, Aleksey; Bobrova, Oksana; Tikunova, Nina

doi:10.1007/s00436-016-5128-9

Cited by 21 publications

(11 citation statements)

References 28 publications

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“…Our present study revealed that both Kobe-type and U.S.-type B. microti were prevalent in small mammalian hosts from Beijing based on the large number of samples tested (Tables 1 and 2)-with Kobe-type more prevalent than U.S.-type. As is known, B. microti has been recognized as a genetically diverse complex group, generally clarified into U.S.-, Munich-, Kobe-, and Hobetsu-(or Ostu-) types [20,28,29]. In Beijing, only Kobe-type B. microti, was detected from small rodents in Miyun, and documented previously [11].…”

Section: Discussionmentioning

confidence: 54%

High prevalence of Babesia microti in small mammals in Beijing

Wei

Wang

et al. 2020

Infect Dis Poverty

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Background Babesiosis is an emerging tick-borne zoonotic infectious disease. Babesia microti is responsible for most cases of human babesiosis globally. It is important to investigate the prevalence of B. microti in the mammalian host population of a specific region in order to elucidate mechanisms of pathogen transmission and to define geographic areas where humans face the greatest risk of exposure. The aim of this study is to understand the prevalence and genotypes of B. microti in the small mammals that are found in Beijing, China. Methods We trapped small mammals from all of the 16 urban, suburban, and outer suburban districts of Beijing during the years 2014, 2017 and 2018. Genomic DNA was extracted from the heart tissues individually and the Babesia 18S rRNA gene was detected by PCR. The genotypes of B. microti were identified based on sequence alignments and phylogenetic analysis. The morphology of the parasites was observed under light microscopy. The risk factors were analyzed statistically based on both univariate analyses and multivariate logistic regression. Results A total of 1391 small mammals were collected. Positive infection of B. microti was detected in 12.1% (168/1391) of small mammals from 15 out of the 16 districts. Both Kobe-type and U.S.-type B. microti, accounting for 9.5% and 2.7%, respectively, were identified. Classic diverse morphologic forms of B. microti were observed. Specific types of ecological habitats including shrub areas, broad-leaved forest, and cropland were revealed to be risk factors associated with B. microti infection. Conclusions This study demonstrated the wide prevalence of B. microti infection in eight species of small mammals in Beijing, with Kobe-type more prevalent than U.S.-type. This study provides fundamental information for the development of informed prevention and control measures by public health authorities; the data gathered indicates a need for further monitoring of both clinical diseases in individuals presenting with babesiosis-like symptoms, as well as the infection status of ticks in high risk areas.

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Section: Discussionmentioning

confidence: 54%

High prevalence of Babesia microti in small mammals in Beijing

Wei

Wang

et al. 2020

Infect Dis Poverty

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“…The duration of B. microti infection in naturally infected ( via tick vector) P. leucopus is unclear; however, chronic infection has been shown to persist in laboratory P. leucopus for seven months and possibly longer [ 9 , 10 , 28 , 29 ]. Chronic infection of B. microti was also observed for approximately five months in naturally infected voles from Russia [ 30 ]. In these ways mice infected over the transmission season (April-July) could remain infected until the following spring, when transplacental transmission could further increase early-season transmission.…”

Section: Discussionmentioning

confidence: 99%

Transplacental transmission of tick-borne Babesia microti in its natural host Peromyscus leucopus

Tufts

Diuk‐Wasser

2018

Parasites Vectors

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BackgroundBabesia microti is an emerging tick-borne pathogen and the causative agent of human babesiosis. Mathematical modeling of the reproductive rate of B. microti indicates that it cannot persist in nature by horizontal tick-host transmission alone. We hypothesized that transplacental transmission in the reservoir population contributes to B. microti persistence and emergence in North American rodent populations.MethodsPeromyscus leucopus were collected from Connecticut and Block Island, Rhode Island and analyzed using a highly specific quantitative PCR (qPCR) assay for infection with B. microti.ResultsIn April, 100% (n = 103) of mice were infected with B. microti. Females exhibited significantly higher parasitemia than their offspring (P < 0.0001) and transplacental transmission was observed in 74.2% of embryos (n = 89). Transplacental transmission of B. microti is thus a viable and potentially important infectious pathway in naturally infected rodent species and should be considered in future theoretical and empirical studies.ConclusionsTo our knowledge, this study is the first to report transplacental transmission of B. microti occurring in its natural reservoir host, P. leucopus, in the United States and the only study that provides a quantitative estimate of parasitemia. This vector-independent pathway could contribute to the increased geographic range of B. microti or increase its abundance in endemic areas.Electronic supplementary materialThe online version of this article (10.1186/s13071-018-2875-8) contains supplementary material, which is available to authorized users.

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“…Evidence suggests that dogs and cats may contribute substantially to the circulation of the pathogen among ticks. Some small mammals, such as voles [22] and other rodents [23], are also involved in the enzootic maintenance and transmission of B. microti .…”

Section: Discussionmentioning

confidence: 99%

Detection of Kobe-type and Otsu-typeBabesia microtiin wild rodents in China's Yunnan province

Chen

Fan

et al. 2017

Epidemiol. Infect.

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Babesiosis is an emerging tick-transmitted zoonosis prevalent in large parts of the world. This study was designed to determine the rates of Babesia microti infection among small rodents in Yunnan province, where human cases of babesiosis have been reported. Currently, distribution of Babesia in its endemic regions is largely unknown. In this study, we cataloged 1672 small wild rodents, comprising 4 orders, from nine areas in western Yunnan province between 2009 and 2011. Babesia microti DNA was detected by polymerase chain reaction in 4·3% (72/1672) of the rodents analyzed. The most frequently infected rodent species included Apodemus chevrieri and Niviventer fulvescens. Rodents from forests and shrublands had significantly higher Babesia infection rates. Genetic comparisons revealed that Babesia was most similar to the Kobe- and Otsu-type strains identified in Japan. A variety of rodent species might be involved in the enzootic maintenance and transmission of B. microti, supporting the need for further serological investigations in humans.

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High prevalence of Babesia microti ‘Munich’ type in small mammals from an Ixodes persulcatus/Ixodes trianguliceps sympatric area in the Omsk region, Russia

Cited by 21 publications

References 28 publications

High prevalence of Babesia microti in small mammals in Beijing

High prevalence of Babesia microti in small mammals in Beijing

Transplacental transmission of tick-borne Babesia microti in its natural host Peromyscus leucopus

Detection of Kobe-type and Otsu-typeBabesia microtiin wild rodents in China's Yunnan province

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