High Prevalence of Atypical Hyperplasia in the Endometrium of Patients With Epithelial Ovarian Cancer

Mingels, Marjanka J.J.M.; Masadah, Rina; Geels, Yvette P.; Otte-Höller, Irene; Kievit, Ineke M. de; Laak, Jeroen van der; Ham, Maaike A.P.C. van; Bulten, Johan; Massuger, Leon F.A.G.

doi:10.1309/ajcptgjopxuw6rvo

Cited by 12 publications

(9 citation statements)

References 39 publications

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“…Up to 42% of women in whom endometrial sampling reveals atypical endometrial hyperplasia are found to have simultaneous endometrial cancer in hysterectomy specimens [15] consistent with the idea that endometrioid endometrial carcinoma evolves via endometrial hyperplasia [16]. Interestingly, some 50% of patients with endometrioid ovarian carcinoma, too, display concurrent atypical endometrial hyperplasia [17], the significance of which remains to be clarified: does endometrial hyperplasia represent an early step of synchronous endometrial tumorigenesis or have relevance for ovarian cancer development as well, given that endometrial epithelial cells are considered to be the origins of endometrioid and clear cell carcinomas of the ovary [18]?…”

Section: Introductionsupporting

confidence: 56%

Converging endometrial and ovarian tumorigenesis in Lynch syndrome: Shared origin of synchronous carcinomas

Niskakoski

Pasanen

Porkka

et al. 2018

Gynecologic Oncology

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Section: Introductionsupporting

confidence: 56%

Converging endometrial and ovarian tumorigenesis in Lynch syndrome: Shared origin of synchronous carcinomas

Niskakoski

Pasanen

Porkka

et al. 2018

Gynecologic Oncology

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“…They concluded that this condition is more frequent in clear cell carcinomas than epitelial ovarian carcinomas. Mingels et al [21] analized histological samples from 186 pacients diagnosed with epithelial ovarian cancer and discovered high prevalence of atypical hyperplasia in the endometrium, and reports in 81 pacients(44%) endometrial lesion who was premalignant in 58(31%) pacients and malignant in 6(3%), primary endometrial carcinoma. Same authors reported a higer body mass index (BMI) in pacients with atypical endometrial hyperplasia in comparation in pacients with normal endometrium, and performed genetical tests who described BRCA mutation carriers in both groups.…”

Section: Resultsmentioning

confidence: 99%

Synchronous Primary Ovarian and Endometrial Carcinomas in a Young PatientCase report and literature review

2020

Rev.Chim.

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Synchronous primary ovarian and endometrial carcinomas is a rare condition encountured in clinical practice, especially in young patients with history of endometriosis. The most frequent histopatological subtype is endometrioid carcinoma. We present a case of a 36-years old patient admitted in the Emergency Department for lower abdominal pain and abnormal uterine bleeding. The clinical and ultrasound examination diagnosed bilateral ovarian cystic tumors, a normal uterine structure and no abdominal fluid colection. Serum levels of ROMA score was performed with normal value. The International Ovarian Tumor Analysis (IOTA) criteria used for ovarian tumors scoring diagnosed a 55% probability for malignant tumors. Laparotomy was performed with prelevation of peritoneal fluid for citology. After right anexectomy was performed, the intraoperative histopathological examination diagnosed endometrioid ovarian carcinoma. Left anexectomy and total hysterectomy with omentectomy and multiple peritoneal biopsy was further performed. The final histopathological examination confirmed endometroid carcinoma in both ovaries and endometrial tissue. Keywords: synchronous genital carcinomas, endometrioid subtype, endometriosis

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“…Two of the 15 patients in Morrison (26) examined tubes from 200 randomly selected patients with endometrial carcinomas (100 were entirely embedded and 100 were routinely sampled without fimbrial sections) and did not find STIC; however, lack of uniform fimbrial sampling is a limitation of this study. Interestingly, Mingels et al (27) reviewed the endometrium in 136 women with serous ovarian carcinomas and found atypical hyperplasia in 32 (24%) and endometrioid carcinoma in 2 (1.5%). Although our findings are not statistically significant, and more data are needed, together the findings suggest that, although infrequent, there may be an association between STIC and nonserous adenocarcinoma of the endometrium that remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Incidental Serous Tubal Intraepithelial Carcinoma and Non-Neoplastic Conditions of the Fallopian Tubes in Grossly Normal Adnexa: A Clinicopathologic Study of 388 Completely Embedded Cases

Seidman

Krishnan

Yemelyanova

et al. 2016

International Journal of Gynecological Pathology

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Serous tubal intraepithelial carcinoma (STIC), the putative precursor of the majority of extrauterine high-grade serous carcinomas, has been reported in both high-risk women (those with a germline BRCA mutation, a personal history of breast carcinoma, and/or family history of breast or ovarian carcinoma) and average risk women from the general population. We reviewed grossly normal adnexal specimens from 388 consecutive, unselected women undergoing surgery, including those with germline BRCA mutation (37 patients), personal history of breast cancer or family history of breast/ovarian cancer (74 patients), endometrial cancer (175 patients), and a variety of other conditions (102 patients). Among 111 high-risk cases and 277 non-high-risk cases, 3 STICs were identified (0.8%), all in non-high-risk women (high risk vs. non-high risk: P=not significant). STIC was found in 2 women with nonserous endometrial carcinoma and 1 with complex atypical endometrial hyperplasia. Salpingoliths (mucosal calcifications), found in 9% of high-risk cases, and fimbrial adenofibromas in 9.9% of high-risk cases, were significantly more common in high-risk as compared with non-high-risk women (1.8% and 2.5%, respectively; P<0.007). Mucinous metaplasia was found in 3.1%, salpingitis isthmica nodosa in 3.4%, hemosiderin or pseudoxanthoma cells in 4.9%, and fibrous luminal nodules in 4.1%. None of these latter features differed significantly in the high-risk versus non-high-risk groups. These findings suggest a possible association between STIC and endometrial hyperplasia and carcinoma, and clarify the frequency of non-neoplastic tubal findings in grossly normal fallopian tubes.

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High Prevalence of Atypical Hyperplasia in the Endometrium of Patients With Epithelial Ovarian Cancer

Abstract: Apart from synchronous endometrial carcinoma, endometrial premalignancies should be taken into account when determining optimal treatment for women diagnosed with EOC.

Cited by 12 publications

References 39 publications

Converging endometrial and ovarian tumorigenesis in Lynch syndrome: Shared origin of synchronous carcinomas

Converging endometrial and ovarian tumorigenesis in Lynch syndrome: Shared origin of synchronous carcinomas

Synchronous Primary Ovarian and Endometrial Carcinomas in a Young PatientCase report and literature review

Incidental Serous Tubal Intraepithelial Carcinoma and Non-Neoplastic Conditions of the Fallopian Tubes in Grossly Normal Adnexa: A Clinicopathologic Study of 388 Completely Embedded Cases

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