High prevalence of antithyroid peroxidase and antiparietal cell antibodies among patients with type 1 diabetes mellitus attending a tertiary diabetes centre in South Africa

Paruk, Imran; Ganie, Yasmeen; Maharaj, Sureka; Pirie, Fraser; Naidoo, V.G.; Nkwanyana, None Ntombifikile M.; Dinnematin, Hilary L; Ramdial, Pratistadevi K.; Motala, Ayesha A.

doi:10.1136/postgradmedj-2016-134420

Cited by 7 publications

(8 citation statements)

References 16 publications

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“…Median age (interquartile range [IQR]) was 22 years (18.3-32); median age at diagnosis 14 years (10.3-20) and median duration of diabetes 9 years. [4][5][6][7][8][9][10][11][12][13][14] The majority were African (Black) 56.4% (n = 114); the remainder included Asian Indian (31.7%), Colored (mixed-race) (7.4%), and White (4.5%).…”

Section: Resultsmentioning

confidence: 99%

“…Two‐hundred and two patients were enrolled in the study, of whom 90 were male and 112 female (Table ). Median age (interquartile range [IQR]) was 22 years (18.3–32); median age at diagnosis 14 years (10.3–20) and median duration of diabetes 9 years . The majority were African (Black) 56.4% ( n = 114); the remainder included Asian Indian (31.7%), Colored (mixed‐race) (7.4%), and White (4.5%).…”

Section: Resultsmentioning

confidence: 99%

“…This was a cross‐sectional observational study that was part of a larger study (Durban Diabetes and Celiac Disease Study) that was undertaken to evaluate the prevalence of CD and thyroid peroxidase antibodies (TPO‐A) in patients with T1DM attending the diabetes clinic at Inkosi Albert Luthuli Central Hospital in Durban, South Africa. The study methods and the prevalence of TPO‐A in this cohort have been previously described …”

Section: Methodsmentioning

confidence: 99%

“…The study methods and the prevalence of TPO-A in this cohort have been previously described. 12 In brief, all subjects aged > 12 years with a diagnosis of T1DM according to the World Health Organization definition, who attended the diabetes clinic during a 12-month period, were invited to participate and consecutively enrolled into the study. Informed consent was obtained from all patients or their guardians and assent from those younger than 18 years.…”

Section: Methodsmentioning

confidence: 99%

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Prevalence and characteristics of celiac disease in South African patients with type 1 diabetes mellitus: Results from the Durban Diabetes and Celiac Disease Study

Paruk

Naidoo

Pirie

et al. 2019

J of Gastro and Hepatol

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Background and Aim The aim of this study was to assess the prevalence and characteristics of celiac disease (CD) in all patients with type 1 diabetes mellitus attending a tertiary adult diabetes clinic in Durban, South Africa. Methods This was a cross‐sectional observational study that screened 202 patients; of these, 56.4% were African (Black), 31.7% Asian Indian, 4.5% White, and 7.4% mixed race. Demographic data, symptoms, and anthropometry were documented. Blood tests included anti‐tissue transglutaminase antibody (tTG), anti‐endomysial antibody (EMA), and anti‐gliadin antibody (AGA). Endoscopy and duodenal biopsy were performed in patients with celiac antibodies. Diagnosis of CD was based on the modified Marsh classification. Results Mean age and mean duration of diabetes were 26.4 ± 11.4 and 10.7 ± 9.1 years, respectively. Celiac antibodies were found in 65 (32.2%) patients: EMA 7.4%, tTG immunoglobulin A (IgA) 8.4%, tTG immunoglobulin G 1.9%, AGA IgA 18.3%, and AGA immunoglobulin G 21.8%. Histological evidence of CD was found in 5.9% (n = 12/202): 2.5% were classed as definite CD (Marsh 3) and 3.4% as potential CD (Marsh 1). None of the patients with CD were symptomatic. The sensitivity of AGA IgA, EMA, and tTG IgA antibodies for detecting histologically proven CD was 66.7%, 50.0%, and 41.7%, respectively. Conclusion The prevalence of CD was similar to reports from western countries. No ethnic specific differences were noted. CD was silent in all patients in this study. The sensitivity of EMA and tTG antibodies was poor and merits further evaluation as screening tools for CD in South African patients with type 1 diabetes mellitus.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Prevalence and characteristics of celiac disease in South African patients with type 1 diabetes mellitus: Results from the Durban Diabetes and Celiac Disease Study

Paruk

Naidoo

Pirie

et al. 2019

J of Gastro and Hepatol

Self Cite

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“…По результатам исследования АТ были выявлены у 8,9% (n=17). Дефицит витамина В 12 был диагностирован у 3,5% (n=7), железодефицитная анемия у 19,3% (n=39) соответственно [20].…”

Section: аутоиммунный гастрит и сахарный диабет 1 типаunclassified

Autoimmune gastritis: comorbid pathology in type 1 diabetes

Derevyanko¹,

Сергеевна²,

Ибрагимова

et al. 2018

Diabetes mellitus

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In recent years noted an increased number of patients with autoimmune diseases (AID), and the special attention deserves combination of several autoimmune pathologies collected in one patient, because such patients requires special tactics of management. Autoimmune diseases of the gastrointestinal tract are less researched and, nevertheless, prognostically unfavorable. Autoimmune gastritis (AIG) has a special place in other stomach diseases, which develops in the aggregate with type 1 diabetes. AIG is a chronic inflammation of the mucous membrane of the body of the stomach, leading to the appearance of atrophy and hypoxecretion. AIG is found in 510% of individuals in general population, with a higher incidence of AIG in patients with diabetes and other established autoimmune pathology. AIG is asymptomatic at the early stage of the disease and clinical manifestations appear after the atrophic changes in the mucous membrane of the stomach develop. Since autoimmune gastritis does not have pathognomonic signs, it can manifest itself in hematological and oncological complications at later stages. This is why screening, early diagnosis, prevention and treatment are very important. Early diagnosis and prevention of AIG and its complications play the main role. This article provides an overview of the worldwide data dedicated to this issue.

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Prevalence of latent and overt polyautoimmunity in type 1 diabetes: A systematic review and meta-analysis

Celis-Andrade,

Morales-González,

Rojas

et al. 2024

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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High prevalence of antithyroid peroxidase and antiparietal cell antibodies among patients with type 1 diabetes mellitus attending a tertiary diabetes centre in South Africa

Cited by 7 publications

References 16 publications

Prevalence and characteristics of celiac disease in South African patients with type 1 diabetes mellitus: Results from the Durban Diabetes and Celiac Disease Study

Prevalence and characteristics of celiac disease in South African patients with type 1 diabetes mellitus: Results from the Durban Diabetes and Celiac Disease Study

Autoimmune gastritis: comorbid pathology in type 1 diabetes

Prevalence of latent and overt polyautoimmunity in type 1 diabetes: A systematic review and meta-analysis

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