High prevalence of Anisakis simplex hypersensitivity and allergy in Sicily, Italy

Heffler, Enrico; Sberna, Maria Eva; Sichili, Stefania; Intravaia, Rossella; Nicolosi, Giovanni; Porto, Morena; Picardi, Giuseppe; Fichera, S.; Crimi, Nunzio

doi:10.1016/j.anai.2015.12.014

Cited by 24 publications

(17 citation statements)

References 25 publications

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“…For an expected prevalence of sensitization to AS=6%, based on the data already known in the literature (12), with the probability alpha=0.05 and beta=0.20, with a preci-sion=4%, the minimum sample size calculated was equal to 140 patients. Allergy Center (9). In this sample, the prevalence of sensitization to AS was about 15%, similar to the one recorded in other coastal areas of Italy (~12%), with the only unexplained exception of Messina (0.8%) (1).…”

Section: Discussionsupporting

confidence: 82%

“…The prevalence of sensitization in Italy is on average 4.5%, with significant geographical differences (variation from 0.4% to 12.7%) due to local culinary traditions, being greater on the Tyrrhenian and Adriatic coasts where it is common to eat raw and marinated fish. In the mainland, the sensitization to AS is essentially related to migration: in Milan and Turin 60% of people sensitized to AS is native to Southern Italy and non-EU countries (9). The cause of sensitization is not clear.…”

Section: Methodsmentioning

confidence: 99%

“…Blatta germanica) and some types of dust mite (Acarus siro, Lepidoglyphus destructor, Tyrophagus putrescentiae, DP) (10). In a recent study of adult patients in Sicily, a region in which the consumption of raw or marinated fish is very common, the co-sensitization to dust mites results in an OR of 1.98 for AS allergy (9). The cross-reactivity is due to a thermostable protein, highly conserved, present in muscle and non-muscle cells: the tropomyosin.…”

Section: Methodsmentioning

confidence: 99%

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Prevalence, molecular characterization, and clinical relevance of sensitization to Anisakis simplex in children with sensitization and/or allergy to Dermatophagoides pteronyssinus

Verga

Pastorino

Casani³

et al. 2017

Eur Ann Allergy Clin Immunol

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Prevalence of the 's (AS) sensitization in children sensitized to (DP) is not known, neither it is to which percentage it might be due to cross-reactivity. The primary objective of the present retrospective cross-sectional study is to evaluate the prevalence of sensitization to AS in children sensitized or allergic to DP. Secondary outcomes were the prevalence of cross-reactivity and clinical relevance of the condition. The prevalence of sensitization to AS differs significantly among patients sensitized and not to DP (13.43% vs. 3.80%; p=0.019). The higher prevalence is mainly due to cross-reactivity with Der p10 (OR=8.86; 95% CI=4.33-40.74; p=0.0001). Currently, the sensitization to AS seems to have no clinical relevance in the pediatric population.

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Section: Discussionsupporting

confidence: 82%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Prevalence, molecular characterization, and clinical relevance of sensitization to Anisakis simplex in children with sensitization and/or allergy to Dermatophagoides pteronyssinus

Verga

Pastorino

Casani³

et al. 2017

Eur Ann Allergy Clin Immunol

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“…Anisakis allergy and gastroallergic anisakiasis are relatively common in Spain and Italy and have been reported from Japan and Korea, but are rarely reported from other parts of Europe or the rest of the world . This is likely due to differences in dietary consumption of raw or pickled fish, with awareness and diagnosis of the disease possibly a contributory factor.…”

Section: Introductionmentioning

confidence: 99%

Anisakis – immunology of a foodborne parasitosis

Nieuwenhuizen

2016

Parasite Immunology

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SummaryAnisakis species are marine nematodes which can cause zoonotic infection in humans if consumed in raw, pickled or undercooked fish and seafood. Infection with Anisakis is associated with abdominal pain, nausea and diarrhoea and can lead to massive infiltration of eosinophils and formation of granulomas in the gastrointestinal tract if the larvae are not removed. Re-infection leads to systemic allergic reactions such as urticarial or anaphylaxis in some individuals, making Anisakis an important source of hidden allergens in seafood. This review summarizes the immunopathology associated with Anisakis infection. Anisakiasis and gastroallergic reactions can be prevented by consuming only fish that has been frozen to −20°C to the core for at least 24 hours before preparation. Sensitization to

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“…Unfavorable eating habits could affect allergens sensitization or raise the risk of developing allergic symptoms (Heffler et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of Taemyeongcheong on allergic reactions

Ryu¹,

Yoou²,

Park³

2016

TANG [HUMANITAS MEDICINE]

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Taemyeongcheong (TMC) is Korean traditional extracted drink with various health ingredients. TMC has been used to treat hepatic damage, obesity, gastritis, and colitis. However, the role of TMC on allergic reaction has not been studied yet. In this study, we investigated the anti-allergic effects of TMC against a compound 48/80-induced systemic anaphylactic reaction and IgE-mediated passive cutaneous anaphylaxis (PCA). TMC significantly inhibited the compound 48/80-induced systemic anaphylactic reaction and IgE-mediated PCA reaction. Furthermore, TMC reduced the levels of interleukin (IL)-1β, IL-4, IL-13, and vascular endothelial growth factor in the serum of mice under PCA reaction. Taken together, these results suggest that TMC can play a useful role as an anti-allergic agent.

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High prevalence of Anisakis simplex hypersensitivity and allergy in Sicily, Italy

Cited by 24 publications

References 25 publications

Prevalence, molecular characterization, and clinical relevance of sensitization to Anisakis simplex in children with sensitization and/or allergy to Dermatophagoides pteronyssinus

Prevalence, molecular characterization, and clinical relevance of sensitization to Anisakis simplex in children with sensitization and/or allergy to Dermatophagoides pteronyssinus

Anisakis – immunology of a foodborne parasitosis

Inhibitory effect of Taemyeongcheong on allergic reactions

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