High prevalence of amyloid in 150 surgically removed heart valves—a comparison of histological and clinical data reveals a correlation to atheroinflammatory conditions

Kristen, Arnt V.; Schnabel, Philipp A.; Winter, Bettina; Helmke, Burkhard; Longerich, Thomas; Hardt, Stefan E.; Koch, Achim; Sack, Falk–Udo; Katus, Hugo A.; Linke, Reinhold P.; Dengler, Thomas J.

doi:10.1016/j.carpath.2009.04.005

Cited by 76 publications

(50 citation statements)

References 21 publications

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“…Computational simulations have shown that b-amyloid structure could be twisted, flexed, and bent by the imposition of shear forces [51]. Amyloid peptides, others then Ab, have been described in conditions such as heart valves exposed to high shear stress [52] or in the joint cartilage [53]. Ab deposits can be formed in conditions associated with brain mechanical load as after brain injury [54], in normal pressure hydrocephalus, or in glaucoma [44].…”

Section: Implications Of the Results And Possible Interpretationsmentioning

confidence: 98%

Mechanical stress related to brain atrophy in Alzheimer's disease

Nogueira

Lafitte

Steyaert

et al. 2015

Alzheimer's & Dementia

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Section: Implications Of the Results And Possible Interpretationsmentioning

confidence: 98%

Mechanical stress related to brain atrophy in Alzheimer's disease

Nogueira

Lafitte

Steyaert

et al. 2015

Alzheimer's & Dementia

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“…In this respect, it has been suggested that recurrent thrombotic events may contribute to the formation of amyloid within CAVD valves 16 . Also, amyloid deposits are reported occur in areas of high mechanical stress 17 . However, a striking feature of CAVD is valve infiltration by lipoproteins, 18 and immunolocalization studies have found Apo‐B and oxidized LDL in CAVD valves.…”

Section: Discussionmentioning

confidence: 99%

Amyloid substance within stenotic aortic valves promotes mineralization

Audet¹,

Côté²,

Couture³

et al. 2012

Histopathology

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“…Senile cardiac amyloidosis Senile cardiac amyloidosis is normally recognized at autopsy [86]. Patients' clinical features include dyspnea, weakness, and fatigue from heart failure or atrial fibrillation.…”

Section: Organ-specific Amyloidosismentioning

confidence: 99%

Currents Concepts on the Immunopathology of Amyloidosis

Bhat

Selmi

Naguwa

et al. 2009

Clinic Rev Allerg Immunol

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Amyloidosis is defined as the extracellular accumulation at systemic or organ-specific level of insoluble low molecular weight protein fibrils manifesting a beta pleated sheet configuration and a characteristic staining pattern. Several different types of proteins may lead to this phenomenon, and amyloidosis is defined by the biochemical nature of the protein in the deposits and further classified according to whether the deposits are localized or systemic, acquired or inherited, and by the resulting clinical phenotype. Amyloidosis includes subtypes such as light chain, associated with serum amyloid A protein, heritable and familial forms, dialysis-related disease, and organ-specific conditions. The pathogenesis and clinical features of these clinical and pathological entities will be critically discussed in this review article.

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High prevalence of amyloid in 150 surgically removed heart valves—a comparison of histological and clinical data reveals a correlation to atheroinflammatory conditions

Cited by 76 publications

References 21 publications

Mechanical stress related to brain atrophy in Alzheimer's disease

Mechanical stress related to brain atrophy in Alzheimer's disease

Amyloid substance within stenotic aortic valves promotes mineralization

Currents Concepts on the Immunopathology of Amyloidosis

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