High prevalence of alcohol use disorders in patients with inflammatory skin diseases applies to both psoriasis and eczema

Gisondi, Paolo

doi:10.1111/bjd.15674

Cited by 5 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, alcohol use disorders including heavy alcohol consumption is more prevalent in patients with psoriasis, and it has been associated with disease severity. Specific interventions to reduce alcohol abuse in these patients are appropriate [ 23 ].…”

Section: Non-pharmacological Treatment Approachesmentioning

confidence: 99%

Treatment Approaches to Moderate to Severe Psoriasis

Gisondi

Giglio

Girolomoni

2017

IJMS

105

View full text Add to dashboard Cite

Psoriasis is a common disease, which has a considerable impact on patients and the health care system. Treatment approaches to the disease may be various because some issues are not definitely addressed. Moreover, the therapeutic paradigms are continuously changing because of the recent approval of new treatments for psoriasis such as interleukin (IL)-17 inhibitors and apremilast. In this review, the factors influencing psoriasis severity, the indications for systemic treatments, the overall parameters to be considered in the treatment choice, life style interventions, and the recommendations for the use, screening, and monitoring of systemic therapies available including acitretin, cyclosporine, methotrexate, apremilast, adalimumab, etanercept, infliximab, secukinumab, ixekizumab, and ustekinumab are discussed. Finally, treatment approaches in special patient populations including children, the elderly, pregnant women, patients with a history of neoplasm, and candidates for surgical procedures are reported.

show abstract

Section: Non-pharmacological Treatment Approachesmentioning

confidence: 99%

Treatment Approaches to Moderate to Severe Psoriasis

Gisondi

Giglio

Girolomoni

2017

IJMS

105

View full text Add to dashboard Cite

show abstract

“…9-11. While associations between AE, psoriasis and mental illness are acknowledged, factors associated with depression, anxiety, and SMI in people with AE or psoriasis are unclear. There are plausible mechanisms to explain the association, for example, evidence suggests individuals with AE or psoriasis engage in unhealthy lifestyle behaviours (e.g., poor diet, smoking, or harmful alcohol intake), [12][13][14][15][16][17] which are associated with increased depression or anxiety risk. 18,19 Disrupted sleep -experienced by individuals with AE due to chronic itch -has been recognised as a risk factor for depression.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with depression, anxiety and severe mental illness among adults with atopic eczema or psoriasis: a systematic review and meta-analysis

Adesanya

Matthewman

Schonmann

et al. 2022

British Journal of Dermatology

View full text Add to dashboard Cite

Background Evidence suggests an association between atopic eczema (AE) or psoriasis and mental illness. However, factors associated with mental illness are unclear. Objectives To synthesise and evaluate all available evidence on factors associated with depression, anxiety, and severe mental illness (SMI) among adults with AE or psoriasis. Methods We searched electronic databases, grey literature databases, and clinical trial registries from inception to February 2022 for studies in adults with AE or psoriasis. Eligible studies were randomised controlled trials (RCTs), cohort, cross-sectional or case-control studies where effect estimates of factors associated with depression, anxiety, or SMI were reported. We did not apply language or geographical restrictions. We assessed risk of bias using the Quality in Prognosis Studies tool. We synthesised results narratively, and if at least two studies were sufficiently homogenous, we pooled effect estimates in a random-effects meta-analysis. Results We included 21 studies (11 observational, 10 RCT). No observational studies in AE fulfilled our eligibility criteria. Observational studies in people with psoriasis mostly investigated factors associated with depression or anxiety – one cross-sectional study investigated factors associated with schizophrenia. Pooled effect estimates suggest being female, and psoriatic arthritis, were associated with depression (female sex:OR = 1.62,95%CI = 1.09-2.40,95%PI = 0.62-4.23, I2 = 24.90%, Tau2 = 0.05; psoriatic arthritis:OR = 2.26,95%CI = 1.56-3.25,95%PI = 0.21-24.23, I2 = 0.00%, Tau2 = 0.00) and anxiety (female sex:OR = 2.59,95%CI = 1.32-5.07,95%PI = 0.00-3956.27, I2 = 61.90%, Tau2 = 0.22; psoriatic arthritis:OR = 1.98,95%CI = 1.33-2.94, I2 = 0.00%, Tau2 = 0.00). Moderate/severe psoriasis was associated with anxiety (OR = 1.14,95%CI = 1.05-1.25, I2 = 0.00%, Tau2 = 0.00), but not depression. Evidence from RCTs suggested adults with AE or psoriasis given placebo had higher depression and anxiety scores compared to comparators given targeted treatment (e.g., biologic agents). Conclusions Our review highlights limited existing research on factors associated with depression, anxiety, and SMI in adults with AE or psoriasis. Observational evidence on factors associated with depression or anxiety in people with psoriasis was conflicting or from single studies, but some identified factors were consistent with those in the general population. Evidence on factors associated with SMIs in people with AE or psoriasis was particularly limited. Evidence from RCTs suggested AE and psoriasis treated with placebo was associated with higher depression and anxiety scores compared to skin disease treated with targeted therapy, however, follow-up was limited, therefore long-term effects on mental health are unclear.

show abstract

“…The prevalence of psoriasis has been showing an increasing trend in certain countries [ 2 , 4 , 5 ]. The etiology of this disorder is not known; however, several risk factors have been identified, including smoking, obesity and alcohol abuse [ 6 , 7 , 8 , 9 ]. T helper (Th) 1 and Th17 lymphocytes are the major regulatory cells known to be involved in the pathogenesis of psoriasis [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Proteinuria and Psoriasis Risk: A Nationwide Population-Based Study

Bae

Kim

Song

et al. 2021

JCM

View full text Add to dashboard Cite

Psoriasis, a chronic inflammatory dermatosis, has been associated with chronic kidney disease or end-stage renal disease. However, the association of the changes or amount of proteinuria with psoriasis development has not been evaluated. Using the Korean National Health Screening database, we assessed psoriasis development until 2018 in 6,576,851 Koreans who underwent health examinations in 2009 and 2011. Psoriasis was defined using the International Classification of Diseases, 10th revision (ICD-10) code L40. The risk of psoriasis was evaluated according to change in proteinuria (never [Neg (no proteinuria)/Neg], new [Neg/Pos (proteinuria present)], past [Pos/Neg] and persistent [Pos/Pos] proteinuria) and the proteinuria amount. During a median 7.23-year follow-up, 162,468 (2.47%) individuals developed psoriasis. After adjustments, the hazard ratio (HR) for psoriasis was higher in the persistent proteinuria group (1.32 [1.24–1.40]) than in the never proteinuria group. The past proteinuria group showed better renal outcome (1.03 [1.00–1.07]) than the new (1.05 [1.01–1.07]) and never proteinuria (reference, 1.00) groups did. The amount of random urine proteinuria was associated with increased HR for psoriasis. Subgroup analyses for age, sex, estimated glomerular filtration rate (eGFR), hypertension and diabetes showed that the persistent proteinuria group had a higher risk of psoriasis than the never proteinuria group, especially at eGFR < 60 mL/min/1.73 m2. Persistent proteinuria is associated with psoriasis risk, and the proteinuria amount significantly affects psoriasis development.

show abstract

High prevalence of alcohol use disorders in patients with inflammatory skin diseases applies to both psoriasis and eczema

Abstract: Linked Article: Gisondi. Br J Dermatol 2017; 177:837–844

Cited by 5 publications

References 18 publications

Treatment Approaches to Moderate to Severe Psoriasis

Treatment Approaches to Moderate to Severe Psoriasis

Factors associated with depression, anxiety and severe mental illness among adults with atopic eczema or psoriasis: a systematic review and meta-analysis

Proteinuria and Psoriasis Risk: A Nationwide Population-Based Study

Contact Info

Product

Resources

About