High Prevalence of Abnormal Nocturnal Oximetry in Patients With Hypertrophic Cardiomyopathy

Eleid, Mackram F.; Konečný, Tomáš; Orban, Marek; Sengupta, Partho P.; Somers, Virend K.; Parish, James M.; Mookadam, Farouk; Brady, Peter A.; Sullivan, Barbara L.; Khandheria, Bijoy K.; Ommen, Steve R.; Tajik, A. Jamil

doi:10.1016/j.jacc.2009.07.030

Cited by 57 publications

(36 citation statements)

References 22 publications

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“…A high risk for OSA was found in more than one third of patients with HCM and is consistent with the 40% rate of OSA confirmed by sleep studies in 80 patients of the present cohort [4]. These results are consistent with a recent report of a high prevalence of oxygen desaturations during sleep suggestive of OSA in another cohort of patients with HCM [18]. Therefore, OSA may help to explain, at least in part, poor sleep quality in patients with HCM.…”

Section: Discussionsupporting

confidence: 93%

Sleep Quality and Quality of Life in Patients with Hypertrophic Cardiomyopathy

Pedrosa¹,

Lima

Drager³

et al. 2010

Cardiology

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Objectives: To evaluate clinical predictors of poor sleep quality and quality of life (QOL) in patients with hypertrophic cardiomyopathy (HCM). Methods: Consecutive stable patients with HCM were evaluated for the risk of obstructive sleep apnea (OSA) by the Berlin Questionnaire, daytime sleepiness by the Epworth Sleepiness Scale, sleep quality by the Pittsburgh Sleep Questionnaire Index and QOL by the Minnesota Living with Heart Failure Questionnaire. Asymptomatic subjects without HCM were used as controls. Results: We studied 84 patients with HCM and 42 controls who were similar with regard to gender (49 vs. 50% males), age [52 (38–62) vs. 47 (33–58) years] and body mass index (27 ± 4 vs. 27 ± 5). HCM diagnosis, high risk for OSA and female gender were independently associated with poor sleep quality in the entire population. Among patients with HCM, poor QOL was independently associated with poor sleep quality, New York Heart Association functional class and diuretic therapy. Conclusion: Poor sleep quality is very common in patients with HCM and may have a negative impact on the QOL, which in turn is an important marker of prognosis in patients with cardiomyopathies.

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Section: Discussionsupporting

confidence: 93%

Sleep Quality and Quality of Life in Patients with Hypertrophic Cardiomyopathy

Pedrosa¹,

Lima

Drager³

et al. 2010

Cardiology

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“…About 80% of our patients presented with SDB, and 44% had relevant sleep apnea fulfilling accepted criteria for specific treatment. These results are comparable with recent data of Eleid and coworkers, 24 who found sleep apnea in about 71% of their patients. Both the cohort and the control patients predominantly had OSA.…”

Section: Discussionsupporting

confidence: 93%

Incidence of Sleep-Disordered Breathing in Patients With Hypertrophic Cardiomyopathy

Prinz

Bitter

Oldenburg

et al. 2011

Congestive Heart Failure

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The authors investigated the prevalence of sleep‐disordered breathing (SDB) together with its clinical correlations in patients with hypertrophic cardiomyopathy (HCM). A total of 113 consecutive patients including 63 patients with HCM (40 men; mean age, 59.5±13.0 years; New York Heart Association class, 2.0±0.9) underwent cardiorespiratory polygraphy in addition to their clinical work‐up including echocardiography. Patients with an apnea‐hypopnea‐index (AHI) ≥5/h were considered to have SDB. If thoracic and abdominal inspiration efforts were documented, SDB was considered to be obstructive sleep apnea (OSA), otherwise SDB was considered to be central sleep apnea (CSA). The age‐ and sex‐matched control group of 50 patients had exclusion of coronary artery disease by angiography, and normal left ventricular (ejection fraction ≥55%) and valvular function. SDB was diagnosed in 52 patients (82.5% vs 72% in the control group; P =not significant) with a mean AHI of 23.0±17.8/h. Severity of SDB was higher in patients with HCM than in the control group (AHI 12.2±7.6/h; P =.003). OSA was documented in 39 patients (AHI 21.2±16.5/h) and CSA in 13 (AHI 28.4±20.9/h). The severity of SDB correlated with New York Heart Association functional class (η=0.9, η2=0.811) and with left ventricular end‐diastolic (r=0.6, P <.01) and left atrial (r=0.4, P <.01) diameter. No correlations were found between SDB and other clinical or echocardiographic parameters. SDB is common in patients with hypertrophic cardiomyopathy, with a predominance of OSA and correlations with markers of left ventricular function. Congest Heart Fail. 2011;17:19–24. ©2011 Wiley Periodicals, Inc.

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“…4,5 Sleep-disordered breathing (SDB), and particularly its most common form, OSA, is highly prevalent and is oft en underdiagnosed among patients with cardiovascular diseases, including patients with HCM. 6,7 In patients who do not have HCM, SDB has been identifi ed as a potentially reversible contributor to decreased functional capacity, [8][9][10] but whether such an association exists in patients with HCM remains unknown. Cardiopulmonary exercise testing provides the most accurate assessment of functional capacity in patients with HCM.…”

mentioning

confidence: 99%

Decreased Exercise Capacity and Sleep-Disordered Breathing in Patients With Hypertrophic Cardiomyopathy

Konečný

Ludka

Orban

et al. 2015

Chest

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High Prevalence of Abnormal Nocturnal Oximetry in Patients With Hypertrophic Cardiomyopathy

Abstract: Abnormal nocturnal oximetry is common in patients with HCM, suggesting that OSA is prevalent. OSA may impact hemodynamics and symptoms in HCM. Further studies are needed to determine the long-term benefit of OSA treatment on hemodynamics and disease progression in HCM.

Cited by 57 publications

References 22 publications

Sleep Quality and Quality of Life in Patients with Hypertrophic Cardiomyopathy

Sleep Quality and Quality of Life in Patients with Hypertrophic Cardiomyopathy

Incidence of Sleep-Disordered Breathing in Patients With Hypertrophic Cardiomyopathy

Decreased Exercise Capacity and Sleep-Disordered Breathing in Patients With Hypertrophic Cardiomyopathy

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