High prevalence of abnormal glucose metabolism in young adult patients with complex congenital heart disease

Ohuchi, Hideo; Miyamoto, Yoshihiro; Yamamoto, Masaki; Ishihara, Hideharu; Takata, Hitoshi; Miyazaki, Aya; Yamada, Osamu; Yagihara, Toshikatsu

doi:10.1016/j.ahj.2009.04.021

Cited by 74 publications

(60 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A high prevalence of abnormal glucose metabolism has been shown in patients with complex ACHD and appears to be associated with central obesity, hepatic and renal dysfunction, diuretic use, and increased plasma renin activity. 70 It would therefore be expected that a significant percentage of the population with moderate or complex ACHD will have diabetes mellitus or abnormal glucose metabolism. Of note, with regard to glucose management, the fasting glucose level in cyanotic patients may be lower because of the high resting catecholamine state and impaired nutritional status 71 ; however, there may concomitantly be increased clearance of insulin by the lung in right-to-left shunts.…”

Section: Prevalencementioning

confidence: 99%

Congenital Heart Disease in the Older Adult

Bhatt¹,

Foster²,

Kuehl³

et al. 2015

Circulation

194

View full text Add to dashboard Cite

Section: Prevalencementioning

confidence: 99%

Congenital Heart Disease in the Older Adult

Bhatt¹,

Foster²,

Kuehl³

et al. 2015

Circulation

194

View full text Add to dashboard Cite

“…Impaired glucose tolerance and prediabetes have been demonstrated in almost 40% of adults with CHD. 304,305 Patients with Down, Turner, and Williams-Beuren syndromes have markedly increased risk of DM ( Table 5). The causes of these important differences from the general population are hard to determine from available data but may relate to increased rates of obesity and reduced physical exercise.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Lui¹,

Saïdi²,

Bhatt³

et al. 2017

Circulation

161

134

View full text Add to dashboard Cite

ABSTRACT:Life expectancy and quality of life for those born with congenital heart disease (CHD) have greatly improved over the past 3 decades. While representing a great advance for these patients, who have been able to move from childhood to successful adult lives in increasing numbers, this development has resulted in an epidemiological shift and a generation of patients who are at risk of developing chronic multisystem disease in adulthood. Noncardiac complications significantly contribute to the morbidity and mortality of adults with CHD. Reduced survival has been documented in patients with CHD with renal dysfunction, restrictive lung disease, anemia, and cirrhosis. Furthermore, as this population ages, atherosclerotic cardiovascular disease and its risk factors are becoming increasingly prevalent. Disorders of psychosocial and cognitive development are key factors affecting the quality of life of these individuals. It is incumbent on physicians who care for patients with CHD to be mindful of the effects that disease of organs other than the heart may have on the well-being of adults with CHD. Further research is needed to understand how these noncardiac complications may affect the long-term outcome in these patients and what modifiable factors can be targeted for preventive intervention.

show abstract

“…CHD mortality continues to decline, and people with CHD are living longer, making managing care into adulthood increasingly important. 45,46 In addition to the management of the cardiac sequelae of CHD (eg, hypertension, cardiac arrhythmias, and endocarditis), effective care of adults with CHD is likely to require attention to the diagnosis and management of noncardiac organ dysfunction such as renal impairment 47 and abnormal glucose metabolism, 47,48 as well as counseling on issues such as contraception and pregnancy, potential genetic transmission of CHD, dental care, diet, optimal weight, exercise, and physical activity. 46 * Mortality rate ratios for "all ages" are based on age-standardized mortality rates.…”

Section: Gilboa Et Almentioning

confidence: 99%

Mortality Resulting From Congenital Heart Disease Among Children and Adults in the United States, 1999 to 2006

et al. 2010

View full text Add to dashboard Cite

Background-Previous reports suggest that mortality resulting from congenital heart disease (CHD) among infants and young children has been decreasing. There is little population-based information on CHD mortality trends and patterns among older children and adults. Methods and Results-We used data from death certificates filed in the United States from 1999 to 2006 to calculate annual CHD mortality by age at death, race-ethnicity, and sex. To calculate mortality rates for individuals Ն1 year of age, population counts from the US Census were used in the denominator; for infant mortality, live birth counts were used. From 1999 to 2006, there were 41 494 CHD-related deaths and 27 960 deaths resulting from CHD (agestandardized mortality rates, 1.78 and 1.20 per 100 000, respectively). During this period, mortality resulting from CHD declined 24.1% overall. Mortality resulting from CHD significantly declined among all race-ethnicities studied. However, disparities persisted; overall and among infants, mortality resulting from CHD was consistently higher among non-Hispanic blacks compared with non-Hispanic whites. Infant mortality accounted for 48.1% of all mortality resulting from CHD; among those who survived the first year of life, 76.1% of deaths occurred during adulthood (Ն18 years of age). Conclusions-CHD mortality continued to decline among both children and adults; however, differences between race-ethnicities persisted. A large proportion of CHD-related mortality occurred during infancy, although significant CHD mortality occurred during adulthood, indicating the need for adult CHD specialty management. (Circulation.

show abstract

High prevalence of abnormal glucose metabolism in young adult patients with complex congenital heart disease

Cited by 74 publications

References 41 publications

Congenital Heart Disease in the Older Adult

Congenital Heart Disease in the Older Adult

Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

Mortality Resulting From Congenital Heart Disease Among Children and Adults in the United States, 1999 to 2006

Contact Info

Product

Resources

About