High prevalence and prolonged shedding with enteric viruses among children with acute diarrhea in Franceville, Southeast of Gabon

Ndjangangoye, Nal Kennedy; Lekana-Douki, Sonia Etenna; Lekolo, Gwladys Mirlande; Mve-Ella, Octavie Banga; Oyegue-Liabagui, Sandrine Lydie; Lékana-Douki, Jean Bernard

doi:10.1016/j.jcvp.2021.100046

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…This could be due to the high prevalence of these viruses among young children, which exposes them to multiple viruses that may infect simultaneously or within a short time frame 5 . Additionally, enteric viruses have been detected in rectal samples of asymptomatic children, either due to asymptomatic infection or prolonged shedding 6 …”

Section: Introductionmentioning

confidence: 99%

“…5 Additionally, enteric viruses have been detected in rectal samples of asymptomatic children, either due to asymptomatic infection or prolonged shedding. 6 Several studies on the dynamics of enteric virus co-infection and its impact on disease severity have shown that young age, daycare attendance, and large households are risk factors for enteric viral coinfection. Children from high-income populations generally have lower rates of co-infections compared to children from lower income regions.…”

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confidence: 99%

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Comparing single versus multiple virus detection in pediatric acute gastroenteritis postimplementation of routine multiplex RT‐PCR diagnostic testing

Hazan,

Goldstein,

Greenberg

et al. 2023

Journal of Medical Virology

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Utilizing multiplex real time polymerase chain reaction (RT‐PCR) for rapid diagnosis of gastroenteritis, enables simultaneous detection of multiple pathogens. A comparative analysis of disease characteristics was conducted between cases with single and multiple viruses. Rotavirus vaccine was introduced in 2010, reaching a 70% coverage in 2 years. All rectal swabs collected from diarrheic children (<5 years) between December 2017 and March 2022 were included. Detection of the same viruses within 2 months was considered a single episode. Episodes with positive stool bacterial PCR were excluded. A total of 5879 samples were collected, revealing 86.9% (1509) with single virus detection and 13.1% (227) with multiple viruses. The most frequent combination was rotavirus and norovirus (27.8%), these infections followed a winter‐spring seasonality akin to rotavirus. Children with multivirus infections exhibited higher immunodeficiency (OR 2.06) rates, but lower food allergy (OR 0.45) and prematurity rates (OR 0.55) compared to single infections. Greater disease severity, evaluated by the Vesikari score, was observed in multivirus episodes (p < 0.001, OR 1.12). Multivirus infections accounted for 13.1% of symptomatic cases in hospitalized young children. Despite vaccination efforts, rotavirus remained prominent, frequently in co‐infections with norovirus. Overall, multivirus infections were linked to more severe diseases than single virus cases.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Comparing single versus multiple virus detection in pediatric acute gastroenteritis postimplementation of routine multiplex RT‐PCR diagnostic testing

Hazan,

Goldstein,

Greenberg

et al. 2023

Journal of Medical Virology

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“…Other publications in the literature are isolated studies of viral, bacterial, or parasitic agents. [10][11][12][13][14][15][16] As such, the aim of our study was to investigate and assess the prevalence of the main diarrheal pathogens in children with diarrhea from southeastern Gabon.…”

Section: Introductionmentioning

confidence: 99%

Molecular Prevalence of Diarrheal Pathogens in Children with Acute Diarrhea in Southeastern Gabon

Ndjangangoye

Lekana-Douki

Oyegue-Liabagui

et al. 2023

The American Journal of Tropical Medicine and Hygiene

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Diarrheal diseases are a major cause of morbidity and mortality in infants and young children, particularly in sub-Saharan countries. In Gabon, there are few data on the prevalence of diarrheal pathogens in children. The aim of this study was to assess the prevalence of diarrheal pathogens in children with diarrhea in southeastern Gabon. Stool samples (n = 284) from Gabonese children 0 to 15 years of age with acute diarrhea were analyzed using polymerase chain reaction targeting 17 diarrheal pathogens. At least one pathogen was detected in 75.7% of samples (n = 215). Coinfection with multiple pathogens was observed in 44.7% of patients (n = 127). Diarrheagenic Escherichia coli was the most commonly detected pathogen (30.6%, n = 87), followed by adenovirus (26.4%, n = 75), rotavirus (16.9%, n = 48), Shigella sp. (16.5%, n = 47), Giardia duodenalis (14.4%, n = 41), norovirus GII (7.0%, n = 20), sapovirus (5.6%, n = 16), Salmonella enterica (4.9%, n = 14), astrovirus (4.6%, n = 13), Campylobacter jejuni/coli (4.6%, n = 13), bocavirus (2.8%, n = 8), and norovirus GI (2.8%, n = 8). Our study provides useful information on the possible causes of diarrheal diseases affecting children in southeastern Gabon. A similar study with a control group of healthy children is needed to assess the burden of the disease attributed to each pathogen.

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Human adenoviruses in children with gastroenteritis: a systematic review and meta-analysis

Khales,

Razizadeh,

Ghorbani

et al. 2024

BMC Infect Dis

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Purpose Human adenoviruses (HAdVs) have always been suggested as one of the main causes of gastroenteritis in children. However, no comprehensive report on the global epidemiology of these viruses in pediatric gastroenteritis is available. Methods A systematic search was conducted to obtain published papers from 2003 to 2023 in three main databases PubMed, Scopus, and Web of Science. Results The estimated global pooled prevalence of HAdV infection in children with gastroenteritis was 10% (95% CI: 9-11%), with a growing trend after 2010. The highest prevalence was observed in Africa (20%, 95% CI: 14–26%). The prevalence was higher in inpatients (11%; 95% CI: 8-13%) and patients aged 5 years old and younger (9%; 95% CI: 7-10%). However, no significant difference was observed between male and female patients (P = 0.63). The most prevalent species was found to be the species F (57%; 95% CI: 41-72%). The most common HAdVs observed in children with gastroenteritis were types 40/41, 38, and 2. Analysis of case-control studies showed an association between HAdV and gastroenteritis in children (OR: 2.28, 95% CI; 1.51–3.44). Conclusion This study provided valuable insights into the importance of HAdVs in children with gastroenteritis, especially in hospitalized and younger children. The results can be used in future preventive measurements and the development of effective vaccines.

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High prevalence and prolonged shedding with enteric viruses among children with acute diarrhea in Franceville, Southeast of Gabon

Cited by 3 publications

References 23 publications

Comparing single versus multiple virus detection in pediatric acute gastroenteritis postimplementation of routine multiplex RT‐PCR diagnostic testing

Comparing single versus multiple virus detection in pediatric acute gastroenteritis postimplementation of routine multiplex RT‐PCR diagnostic testing

Molecular Prevalence of Diarrheal Pathogens in Children with Acute Diarrhea in Southeastern Gabon

Human adenoviruses in children with gastroenteritis: a systematic review and meta-analysis

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