High Prevalence and Genotypic Diversity of the Human Papillomavirus in Amazonian Women, Brazil

Rocha, Danielle Albuquerque Pires; Filho, Roberto Alexandre Alves Barbosa; Queiroz, Francisca Andrade de; Santos, Cristina Maria Borborema dos

doi:10.1155/2013/514859

Cited by 14 publications

(18 citation statements)

References 22 publications

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“…Human papillomavirus (HPV) infection is the most prevalent sexually transmitted disease (STD) worldwide, and with 137,000 new cases annually in Brazil [Rocha et al, ]. Although, HPV infection is not sufficient to cause squamous intraepithelial lesion development, 90% of women with cervical cancer are positive for HPV infection, and the occurrence of cervical lesions is concentrated in the Amazon region [De Oliveira et al, ; Lorenzi et al, ].…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus: Prevalence and factors associated in women prisoners population from the Eastern Brazilian Amazon

et al. 2014

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This study aimed to examine the prevalence of human papillomavirus (HPV) and the associated factors among female prisoners in Ananindeua City, State of Pará, Brazil. In 2010, 190 cervical samples were obtained, and Pap smear and polymerase chain reaction (GE Health Care™, Uppsala, Sweden) were performed. Additionally, a questionnaire was used. The prevalence of HPV was 10.5%, and the presence of cervical intraepithelial neoplasia grade I (n = 33, 17.5%; P < 0.1) was associated with HPV infection. The presence of low-grade squamous intraepithelial lesions was greater in women with HPV than in those without HPV infection, indicating that HPV infection is a risk factor for such injuries and that viral screening and prevention are extremely important in public health among female prisoners in Amazon.

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Section: Introductionmentioning

confidence: 99%

Human papillomavirus: Prevalence and factors associated in women prisoners population from the Eastern Brazilian Amazon

et al. 2014

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“…The majority of HPV infections are clinically unapparent or asymptomatic in immunocompetent individuals [33,34]. However, the immunosuppression caused by HIV seems to favor infection by multiple HPV genotypes, which, if oncogenic, might contribute to the progression of intraepithelial lesions to CIN.…”

Section: Studies On the General Population Of The North Region Of Bramentioning

confidence: 99%

Prevalence high risk Human Papillomavirus (HPV) in HIV-infected women from Belém, Pará, Amazon region of Brazil: A cross-sectional study

Monteiro¹,

Fonseca²,

Silva³

et al. 2020

Preprint

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Background: Human papillomavirus (HPV) is the most common sexually transmitted disease in the world. Several studies have shown a higher prevalence of HPV infection in HIV-infected women. The aim of this study was to determine the prevalence and the genotype diversity of HPV infection in HIV-infected women.Methods: From April 2010 to December 2012 cervical specimens were collected from 169 HIV-infected women who screening for cervical cancer at Reference Unit in Belém. The detection of HPV infection was performed by nested PCR and HPV type was performed using the commercial kit.Results: The prevalence of HPV infection was 63,3%. Of the 47 genotyped samples, 40,4% was found positive for high risk-HPV 16 and 12.8% for high risk-HPV 52. HPV infection was predominant in the group of women with no incidence of cytological abnormalities and more prevalent in women of reproductive age, unmarried, low education level and who used condoms during sexual intercourse. It was observed an association between HPV infection and independent variables, such as condom use, multiple sexual partners and history of sexually transmitted diseases.Conclusions: High-risk types of HPV infection were prevalent in our study. Infection with multiple high-risk HPV genotypes may potentiate the development of cervical cancer in HIV-infected women.

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“…Although no study has provided strong evidence for carcinogenicity of HPV66, and its single detection is rare in cervical cancer, knowledge on the natural history of HPV 66 in cervical lesion development is still incipient and needs to be investigated. In other regions of Brazil, HPV 58, 31, 33 and 56 were the second most prevalent HPV types among women with cervical abnormalities [5,37,[44][45][46][47]. In the Northeast region, HPV 58, 31, 74, 18 and 16 were the second most prevalent HPV types in abnormal cervical samples [14,[30][31][32][33][34][35].…”

Section: Hpv Groupmentioning

confidence: 99%

Prevalence of human papillomavirus types associated with cervical lesions in Sergipe state, Northeastern Brazil: high frequency of a possibly carcinogenic type

et al. 2018

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Persistent infection with high-risk human papillomavirus (HPV) is the main cause of cervical cancer and the prevalence of HPV types varies depending on the geographic region. Therefore, this study assessed the prevalence of HPV types in women with cervical lesions from Sergipe state, Northeastern Brazil. A cross-sectional study was conducted in women with cervical lesions from March to December 2014. These lesions were investigated by PCR and HPV types were identified by DNA sequencing. 432 patients were included, of which 337 patients tested positive for HPV. Eighteen different HPV types were detected, and high-risk HPV types were detected in 69.2%. HPV 16 (63.4%) was the most prevalent HPV type found, followed by HPV 66 (4.6%), HPV 18 (1.6%) and HPV 45 (1.4%). These results highlight the importance of the high prevalence of HPV 66, which is a possibly carcinogenic virus type not covered by the available vaccines. The prevalence of HPV 16 was high in the studied population, reaffirming the importance of young vaccination. However, the high prevalence of HPV 66 found in this study shows the importance of monitoring the diversity of HPV types in different populations and geographic regions to better understand the impacts of current HPV vaccines.

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High Prevalence and Genotypic Diversity of the Human Papillomavirus in Amazonian Women, Brazil

Cited by 14 publications

References 22 publications

Human papillomavirus: Prevalence and factors associated in women prisoners population from the Eastern Brazilian Amazon

Human papillomavirus: Prevalence and factors associated in women prisoners population from the Eastern Brazilian Amazon

Prevalence high risk Human Papillomavirus (HPV) in HIV-infected women from Belém, Pará, Amazon region of Brazil: A cross-sectional study

Prevalence of human papillomavirus types associated with cervical lesions in Sergipe state, Northeastern Brazil: high frequency of a possibly carcinogenic type

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