In northern Pakistan, the northwestern syntaxis of the Himalaya is marked by the spur of the Nanga Parbat-Haramosh massif, bounded by the Arc formations of Ladakh and Kohistan, and located south of the Karakorum range. The three units are separated by two major tectonic features, corresponding to late reactivation of the southern Indus-Tsangpo suture and northern Shyok suture. Field mapping in the as-yet poorly known Nanga Parbat-Haramosh massif-Karakorum contact zone, together with structural, metamorphic, and geochronological data, has led to new constraints on the interpretation of this key zone, viz.: (1) the backarc belt continues without interruption from Ladakh to Kohistan; (2) the southern Karakorum, the Arc, and the northernmost part of the Nanga Parbat-Haramosh massif display the same recumbent isoclinal folds and related metamorphic schistosity as the major structural event;(3) ductile deformation ended after 6 or 7 Ma; (4) in front of the Nanga Parbat spur, there is no evidence of normal-type faulting, or of Karakorum indentation, either considering the lithological boundaries or the metamorphic fabric; (5) on both sides of the spur, the right-lateral and left-lateral cartographic displacements mainly reflect the late doming of the initial arc-massif contact, a south-directed shear zone. Thus, the three units, east of the Raikot fault, define an east-west-trending broad zone that has thermally and tectonically behaved as a single crustal piece. The northern part of the Nanga Parbat-Haramosh massif can be considered to be a large dome in the westward extension of the Karakorum domes, a line of domes that developed east of the Raikot fault and possibly initiated as a crustal-scale fold system, induced by broad and diffuse northwest-southeast dextral shearing in a transpressive regime.