High-pressure liquid chromatography in lab-on-a-chip devices

Miniaturized Systems for Analytical Separations I: Systems Based on a Hydrodynamic Flow

“…This fact is in agreement with the recordings shown in the article published by S. Ehlert and U. Tallarek [40], reproduced from a presentation by Vollmer and Miller [45]. As can be seen, the HPLC Chip offers increased resolution and superior peak shape compared to conventional nano-LC [40] with permission from Springer) using the same adsorbent particles and similar packed-bed dimensions. As can be seen, the HPLC Chip offers increased resolution and superior peak shape compared to conventional nano-LC [40] with permission from Springer) using the same adsorbent particles and similar packed-bed dimensions.…”

An integrated microfluidic chip enabling control and spatially resolved monitoring of temperature in micro flow reactors

“…Particularly attractive about this technology is the possibility to combine different processes, e.g., chemical synthesis [9][10][11][12][13][14][15][16][17] and analytical observation [18][19][20][21][22][23][24][25][26][27] in a dead-volume-free manner on a single substrate [28,29]. The prospect of using only tiny amounts of precious chemicals in integrated chips opens up new avenues for the exploration of novel synthetic routes and the exploration of chemical diversity.…”

Fast electrically assisted regeneration of on-chip SERS substrates

“…23 This often irreversible adsorption of analytes to the SERS-active surface causes sample carry-over and impedes the broad application of SERS as detection technique in advanced lab-on-a-chip applications such as flow synthesis [24][25][26][27] or separation techniques. 28 Especially in chipbased separation techniques there is a great demand for label-free detection methods. [29][30][31][32] The corresponding application of SERS could thus be a break-through in chip electrophoresis, chip chromatography or flow chemistry.…”