High-pressure Liquid Chromatographic Determination of Camphor and Parachlorophenol in Camphorated Parachlorophenol

Musto, Joseph D.; Sane, Jayant N.; Warner, Victor D.

doi:10.1002/jps.2600670239

Cited by 7 publications

(1 citation statement)

References 3 publications

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“…Camphor can be determined individually by reversed‐phase high‐performance liquid chromatography with ultraviolet detection (HPLC/UV) in a 2,4‐dinitrophenylhydrazone derivative form or without derivatization by gas chromatography with flame‐ionization detection (GC/FID) and normal‐phase HPLC/UV (The United States Pharmacopeia ; Musto et al ., ; Gallicano et al ., ; Kelly et al ., ). The derivatization of camphor needs extended reaction time (18 h), which is necessary to maximize the yield of camphor–2,4‐dinitrophenylhydrazone.…”

Section: Introductionmentioning

confidence: 97%

Convergence chromatographic determination of camphor in the essential oil of Tanacetum parthenium L.

Végh

Riethmüller

Tóth

et al. 2016

Biomedical Chromatography

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Feverfew (Tanacetum parthenium L., Asteraceae) is a perennial medicinal plant which has been used to alleviate the symptoms of migraine, headache and rheumatoid arthritis and possesses numerous pharmacological activities. An ultra-high-performance supercritical fluid chromatographic method (UHPSFC) was developed and validated in accordance with the International Conference on Harmonization guidelines in order to determine the camphor content of the volatile oil, which was accurate, precise, robust and selective. The method was validated for specificity, accuracy (100.2%), repeatability and intermediate precision, linearity (r > 0.999), limit of detection (2.055 μg/mL), limit of quantification (6.228 μg/mL) and robustness. The common range of accuracy and linearity was between 0.125 and 1.000 mg/mL. Steam distillation was carried out in order to study the essential oil yield of three different T. parthenium L. samples originating from Hungarian medicinal herb collections. The camphor content of the essential oils from the aerial parts of feverfew samples from different origin was compared. Although the composition of the essential oil is well reported, a validated quantitative UHPSFC method for the determination of the constituents is presented herein for the first time.

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Section: Introductionmentioning

confidence: 97%