High-pressure homogenization-assisted extraction of bioactive compounds from Ruta chalepensis

Gali, Lynda; Bedjou, Fatiha; Velikov, Krassimir P.; Ferrari, Giovanna; Donsı̀, Francesco

doi:10.1007/s11694-020-00525-x

Cited by 19 publications

(13 citation statements)

References 31 publications

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“…The general, Clausena and Ruta , the main sources of chalepin ( 2 ) and chalepensin ( 2 ), are well known for their uses in traditional medicines, and different studies have established their bioactivities [ 27 , 28 ]. Chalepin ( 1 ) and chalepensin ( 2 ) have emerged as two major bioactive components in many of those plants through bioassay-guided isolation protocols, and their bioactivities include antimicrobial, anti-inflammatory, anticancer, antiviral and many more.…”

Section: Bioactivitymentioning

confidence: 99%

Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential

et al. 2021

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Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis L. (Fam: Rutaceae) but also distributed in various species of the genera Boenminghausenia, Clausena and Ruta. The distribution of these compounds appears to be restricted to the plants of the family Rutaceae. To date, there have been a considerable number of bioactivity studies performed on coumarins 1 and 2, which include their anticancer, antidiabetic, antifertility, antimicrobial, antiplatelet aggregation, antiprotozoal, antiviral and calcium antagonistic properties. This review article presents a critical appraisal of publications on bioactivity of these 3-prenylated coumarins in the light of their feasibility as novel therapeutic agents and investigate their natural distribution in the plant kingdom, as well as a plausible biosynthetic route.

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Section: Bioactivitymentioning

confidence: 99%

Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential

et al. 2021

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“…HSM is reported to efficiently disaggregate cell lumps but to have a limited capacity of “opening” plant cells through mechanical disruption of cell walls and membranes (Donsì & Velikov, 2020). In contrast, HPH treatment represents a fast and effective method for achieving full cell disruption into fine debris, hence causing the almost complete release of intracellular bioactive compounds entrapped into an aqueous suspension, resulting in high extraction yields (Wang et al ., 2014; Mustafa et al ., 2018; Jurić et al ., 2019; Xing et al ., 2019; Gali et al., 2020). Remarkably, the HPH technique is suitable for industrial applications due to the ease of operation, scalability, reproducibility, and high throughput (Schultz et al ., 2004).…”

Section: Introductionmentioning

confidence: 99%

Lycopene‐rich cream obtained via high‐pressure homogenisation of tomato processing residues in a water–oil mixture

Jurić

Ferrari

et al. 2021

Int J of Food Sci Tech

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Tomato processing residues are still rich in bioactive compounds that may be recovered and reused, with environmental and economic benefits. This short communication discloses for the first time that the highpressure homogenisation (HPH) treatment of tomato residues in the presence of water and sunflower oil is able to promote the extraction of bioactive compounds concurrently to the formation of an oil-in-water emulsion stabilised by the micronized residues. The mechanical disruption effect of HPH improved the mass transfer of lycopene into the oil phase, and formed fine fibrous debris, improving stabilisation and visual appearance of the emulsion. Results showed a progressive increase of lycopene concentration in the cream phase up to 5 HPH passes and a concurrent reduction of its content in the pellet. Total polyphenols content and antioxidant activity in the aqueous phase gradually decreased when increasing the number of passes, suggesting their progressive transfer in the cream phase. The proposed process that relies on a purely physical treatment and uses only water/sunflower oil as extraction media resulted in the production of a lycopene-rich cream of potential use as a functional food ingredient.

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“…The aqueous AFR suspensions obtained by HPH are made of finely milled cellular debris, where cellulose is partly defibrillated and activated. This technology has already been tested on tomato peels, spent coffee grounds, sesame seeds, and vegetable tissue [16][17][18]. The full exploitation of micronized by-products in final products, such as edible coatings and films, or oil structuring systems, investigated in WP4, by combining partly activated cellulose with other bioactives naturally contained in the residues [15], also represents an original approach.…”

Section: Discussionmentioning

confidence: 99%

“…The tailored use of enzymes to achieve high yields of NC with higher selectivity, lower energy costs, and milder operating conditions than chemical processes [17], as well as the use of cellobiome of bacterial origin to obtain NC of variable size and relative content of amorphous and crystalline domains [18], represent other elements of novelty in cellulose recovery from AFRs.…”

Section: Discussionmentioning

confidence: 99%

A Technology Platform for the Sustainable Recovery and Advanced Use of Nanostructured Cellulose from Agri-Food Residues (PANACEA Project)

Donsı̀

Bartolucci

Bettotti

et al. 2020

The First International Conference on &Amp;ldquo;Green” Polymer Materials 2020

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The European food sector generates about 250 million ton/year of by-products and waste, of which around 10% is from fruit and vegetable processing, with a heavy environmental burden. The agri-food residues (AFRs) contain a significant fraction of cellulose and bioactive compounds, which, if recovered, are high added-value material components. The reduction of cellulose down to nano-sized crystalline structures (nanocellulose, NC) provides versatile building blocks, which self-assemble into new materials with superior performances. The PANACEA project, within the frame of PRIN 2017 call supported by the Italian Ministry of University and Research, proposes an approach based on the recovery of cellulose and bioactive compounds from AFRs, with high yield, at various degrees of hierarchical organization, by cascading different physical and chemical processes of increasing complexity, including physical processes and microbial digestion to obtain micro-and nano-sized cellulose structures while preserving their bioactivity. Chemical and enzymatic processes are used to isolate, purify, and functionalize NC at different levels of hierarchical organization, and to design advanced functional materials such as food ingredients, edible coatings, functional colloids, biocides, and flame retardants.

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High-pressure homogenization-assisted extraction of bioactive compounds from Ruta chalepensis

Cited by 19 publications

References 31 publications

Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential

Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential

Lycopene‐rich cream obtained via high‐pressure homogenisation of tomato processing residues in a water–oil mixture

A Technology Platform for the Sustainable Recovery and Advanced Use of Nanostructured Cellulose from Agri-Food Residues (PANACEA Project)

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