High-precision neural stimulation through optoacoustic emitters

Shi, Linli; Jiang, Ying; Zheng, Nan; Cheng, Ji‐Xin; Yang, Chen

doi:10.1117/1.nph.9.3.032207

Cited by 11 publications

(10 citation statements)

References 119 publications

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“…In addition to the micropore formation and cavitations, [74,75] more recent studies also indicated that mechanosensitive ion channels are responsible for the activation of neurons. [76,77] Bidirectional brain interfaces are important research tools to understand brain circuits, potential treatments for neurological disease and bridges to brain computer interface for broad applications. In addition to electrical recording, there are other modalities for recording neural activity in the brain, [78] such as fiber photometry, calcium imaging with a Gradient-Index (GRIN) lens, and microdialysis providing orthogonal ways to record neural activity in the brain.…”

Section: Discussionmentioning

confidence: 99%

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Multifunctional Fiber‐Based Optoacoustic Emitter as a Bidirectional Brain Interface

Zheng

Jiang

et al. 2023

Adv Healthcare Materials

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A bidirectional brain interface with both “write” and “read” functions can be an important tool for fundamental studies and potential clinical treatments for neurological diseases. Herein, a miniaturized multifunctional fiber‐based optoacoustic emitter (mFOE) is reported thatintegrates simultaneous optoacoustic stimulation for “write” and electrophysiology recording of neural circuits for “read”. Because of the intrinsic ability of neurons to respond to acoustic wave, there is no requirement of the viral transfection. The orthogonality between optoacoustic waves and electrical field provides a solution to avoid the interference between electrical stimulation and recording. The stimulation function of the mFOE is first validated in cultured ratcortical neurons using calcium imaging. In vivo application of mFOE for successful simultaneous optoacoustic stimulation and electrical recording of brain activities is confirmed in mouse hippocampus in both acute and chronical applications up to 1 month. Minor brain tissue damage is confirmed after these applications. The capability of simultaneous neural stimulation and recording enabled by mFOE opens up new possibilities for the investigation of neural circuits and brings new insights into the study of ultrasound neurostimulation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Multifunctional Fiber‐Based Optoacoustic Emitter as a Bidirectional Brain Interface

Zheng

Jiang

et al. 2023

Adv Healthcare Materials

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“…Recently, there has been growing interest in the photoacoustic effect, with extensive exploration across various fields, including biomedicine, 1 spectrum measurement, 2 and particle manipulation. 3 In the realm of the biomedical field, numerous technologies based on the photoacoustic effect have been widely applied, including photoacoustic imaging technology, 4,5 the photoacoustic flow cytometry technique, 6 biological neuromodulations, 7,8 and photothermal/photoacoustic theranostic platform technology. 9,10 Notably, photoacoustic imaging technology, characterized by its high contrast, resolution, and imaging depth, is widely utilized in microscopic imaging and macro-biological tissue imaging.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of the photoacoustic effect during the light–particle interaction

Ji,

Sun,

Ren

et al. 2024

Nanoscale

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“…More specifically, ultrasound applied with an endoscope has several current roles, including drainage of lesions, visualization and characterization of lesions, injection, surgery, and vascular intervention [5]. Another application under research is the application of ultrasound to brain cells for neurostimulation [6,7,8]. This last application requires ultrasound in very localized areas with high pressures and bandwidths.…”

Section: Introductionmentioning

confidence: 99%

Portable laser ultrasound system by using high power diode lasers for endoscopic biomedical applications

Sánchez Rodas,

Gallego Cabo,

Oraevsky

et al. 2024

Photons Plus Ultrasound: Imaging and Sensing 2024

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Medical ultrasound is a diagnostic and treatment method that employs ultrasonic signals as carriers of information. It boasts a broad range of applications, including the visualization of internal bodily structures, the detection of underlying diseases and cellular stimulation. Presently, the most employed ultrasound transducer relies on the principles of piezoelectricity. Nonetheless, piezoelectric transducers may encounter limitations in terms of bandwidth. However, the ultrasound generated by laser through the optoacoustic effect has a large bandwidth, and by using high power laser diodes we can reduce the size of the transducer, enabling endoscopy ultrasound applications. We have designed and implemented a portable endoscopic ultrasonic generator using high power diode lasers and ultrasound generating bi-composites (candle soot-PDMS). We have reduced the size of the ultrasound generating system (laser diode, laser driver and composite) to a width of 5.5 mm making it suitable for an endoscopy application. We have designed and manufactured the control instrumentation of the ultrasonic generation system in a single small instrument (generation of electrical pulses and voltage control). The ultrasonic generation system was characterized, obtaining ultrasonic signals with a bandwidth of 40 MHz, pressures of 264.29 kPa and an optoacoustic conversion efficiency of 2.5x10 -3 Pa/(W/m 2 ).

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High-precision neural stimulation through optoacoustic emitters

Cited by 11 publications

References 119 publications

Multifunctional Fiber‐Based Optoacoustic Emitter as a Bidirectional Brain Interface

Multifunctional Fiber‐Based Optoacoustic Emitter as a Bidirectional Brain Interface

Enhancement of the photoacoustic effect during the light–particle interaction

Portable laser ultrasound system by using high power diode lasers for endoscopic biomedical applications

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