High‐Precision Micropatterning of Polydopamine by Multiphoton Lithography

Abstract

Mussel‐inspired polydopamine (PDA) initiates a multifunctional modification route that leads to the generation of novel advanced materials and their applications. However, existing PDA deposition techniques still exhibit poor spatial control, have a very limited capability of micropatterning, and do not allow local tuning of the PDA topography. Herein, PDA deposition based on multiphoton lithography (MPL) is demonstrated, which enables full spatial and temporal control with nearly total freedom of patterning design. Using MPL, 2D microstructures of complex design are achieved with pattern precision of 0.8 µm without the need of a photomask or stamp. Moreover, this approach permits adjusting the morphology and thickness of the fabricated microstructure within one deposition step, resulting in a unique tunability of material properties. The chemical composition of PDA is confirmed and its ability for protein enzyme immobilization is demonstrated. This work presents a new methodology for high‐precision and complete control of PDA deposition, enabling PDA incorporation in applications where fine and precise local surface functionalization is required. Possible applications include multicomponent functional elements and devices in microfluidics or lab‐on‐a‐chip systems.

Trendbericht: Makromolekulare Chemie 2023

“…Topolniak und Mitarbeitende strukturierten über die Multiphotonenlithografie hochaufgelöst Polydopaminoberflächen. 62) Blasco und Team entwickelten eine Formgedächtnistinte für den 4-D-Druck (mit der Zeit als vierter Dimension, Abbildung 6). 63) Damit programmierten sie ein Formgedächtnis in additiv gefertigte Polymere.…”

Preparation and Properties of PDMS Surface Coating for Ultra-Low Friction Characteristics

“…24,25 However, the surface of the substrate also needs plasma treatment, and the preparation process is more complicated. 26 Plasma surface treatment is one of the fastest and most effective surface modification strategies, only requiring a few seconds to complete the hydrophilic modification of polymers (such as butyl rubber). 27 However, plasma radiation can cause substitution of hydrophilic groups, which is accompanied by the directional movement of small molecules inside the polymer.…”

Abalone‐Inspired Adhesive and Photo‐Responsive Microparticle Delivery Systems for Periodontal Drug Therapy

“…Attributing its splendid micron‐scale maneuverability, microfluidic technology has drawn increasing attention to the fabrication of MPs for drug delivery systems. [ 13 , 14 , 15 , 16 ] With the addition of energy‐converting responsive materials during the fabrication processes, such as graphene oxide, [ 17 , 18 ] polydopamine, [ 19 ] and black phosphorus (BP), [ 20 , 21 , 22 ] these MPs can also be endowed with controllable drug release properties upon external stimuli like near‐infrared ray (NIR) irradiation. [ 23 , 24 , 25 , 26 , 27 ] In contrast, various adhesive stratagems have been employed by natural creatures to guarantee their survival.…”