High Plasma Pentraxin 3 Levels in Diabetic Polyneuropathy Patients with Nociceptive Pain

Abstract

Diabetic polyneuropathy is the most common neurologic complication of diabetes mellitus. Underlying mechanisms of diabetic polyneuropathy are related to various metabolic and inflammatory pathways. Pentraxin 3 (PTX3) is an acute phase protein that is produced locally at the inflammatory sites by several cell types. Thioredoxin binding protein 2 (TBP2) is a thioredoxin regulator involved in intracellular energy pathways and cell growth. We measured the plasma levels of PTX3 and TBP2 in type 2 diabetic patients (n = 27) with pain complaints and compared their levels with those of healthy age-and sex-matched subjects (n = 24). Moreover, the diabetic patients were divided into two groups using the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) pain scale: patients with nociceptive pain that is caused by tissue damage and patients with neuropathic pain that is caused by nerve damage. Patients with LANSS scores of < 12 were considered to have nocicceptive pain (n = 15), while patients with LANSS scores of ≥ 12 were considered to have neuropathic pain (n = 12). We found that PTX3 levels were significantly higher in diabetic patients compared to controls (p = 0.03), but there was no significant difference in the TBP2 levels. Importantly, patients with nociceptive pain had significantly higher PTX3 levels compared to patients with neuropathic pain (p < 0.05). Thus, plasma PTX3 levels can be helpful for discrimination of nociceptive pain from neuropathic pain in diabetic patients. We propose that PTX3 may contribute to the onset of nociceptive pain.

Study of the Relation between Plasma PTX3 Levels and Preclinical Atherosclerotic Cardiovascular Complications in Type 2 Diabetic Patients

“…Our study are in agreement with [9] who, showed that serum pentraxin-3 was significantly higher in diabetic patients compared to controls Yuichi et al,2018 also found that serum PTX3 level was significantly positively correlated with existence of diabetes, HbA1c (r = 0.379, P<0.001; r = 0.431, P<0.001).…”

Aqueous humor pentraxin-3 levels in patients with diabetes mellitus

“…But at the same time it has been shown that diabetic vascular complications apart from DR also affect the serum levels of PTX3 protein. [38][39][40] Another limitation of our study was its relatively small sample size. It was because of PTX3 levels might be affected by several systemic diseases such as cardiovascular or cerebrovascular diseases, chronic kidney and liver failure, autoimmune disorders, irregular systemic hypertension.…”

Anti-diabetic Effects of Berberis cretica Extract in INS-1E Cells

“…Type 2 diabetes mellitus is a disorder characterized by progressive loss of pancreatic beta cell function and resistance to the effects of insulin in organs such as muscle, fat and liver (Ferranini, 1998). Chronic systemic inflammation is the main reason of vascular complications in DM (Salcini et al, 2016). Berberine has been used for the adjuvant treatment of type 2 diabetes mellitus, hyperlipidemia, and hypertension (Lan et al, 2015).…”