High Plasma Norepinephrine Levels Associated with .BETA.2-Adrenoceptor Polymorphisms Predict Future Renal Damage in Nonobese Normotensive Individuals

Masuo, Kazuko; Katsuya, Tomohiro; Sugimoto, Ken; Kawaguchi, Hideki; Rakugi, Hiromi; Ogihara, Toshio; Tuck, Michael L.

doi:10.1291/hypres.30.503

Cited by 23 publications

(30 citation statements)

References 35 publications

(31 reference statements)

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“…7,[20][21][22] Zoccali et al 20,22 reported that the degree of sympathetic nervous activation might relate to the occurrence of fatal cardiovascular events. We also observed previously that 23 higher plasma NE levels could predict future renal injury in non-obese, normotensive individuals. Thus, one could speculate that sympathetic nervous activation might be the trigger linking obesity to impairment in renal function.…”

Section: Introductionsupporting

confidence: 81%

“…11,16,20 Our earlier study showed that high plasma NE levels could predict future renal injury even in non-obese, normotensive subjects. 23 In addition, we reported in a recent study that WL might contribute to the improvement in renal function that accompanies suppression of muscle sympathetic nerve activity in obese subjects with metabolic syndrome. 30 In the present study, we observed that long-term WL, even mild or moderate, was associated with a reduction in sympathetic activity with concomitant improvement in renal function, as assessed from measures of serum creatinine and estimated CCr.…”

Section: Discussionmentioning

confidence: 93%

“…30 In the present study, we observed that long-term WL, even mild or moderate, was associated with a reduction in sympathetic activity with concomitant improvement in renal function, as assessed from measures of serum creatinine and estimated CCr. Taken together, activation of the sympathetic nervous system is an important factor in the onset and development of obesity-related renal injury, 7,20,22,23 and hence WL Renal function during weight loss K Masuo et al programs should be initiated and convey some degree of renal protection in the overweight/obese patient. Glomerular hyperfiltration, 41 hyperleptinemia, 43,44 insulin resistance 30 and stimulation of the RAS, 21,45 accompanying heightened sympathetic nervous activity, may contribute to renal injury in obesity.…”

Section: Discussionmentioning

confidence: 99%

“…30 In the present study, we did not measure RAS parameters, and hence cannot unequivocally assess the contributions of the RAS on renal function improvement. In addition, we previously reported that only plasma NE, but not homeostasis model assessment-insulin resistance or leptin, 23 could predict future renal injury in non-obese, normotensive subjects. It would seem, therefore, that the contributions of insulin resistance or hyperleptinemia on renal function seem not to be as strong as the influence of sympathetic nervous activation.…”

Section: Discussionmentioning

confidence: 99%

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Effects of weight loss on renal function in overweight Japanese men

et al. 2011

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Obesity is known as an independent risk factor for renal injury. Sympathetic nerve activation may have an important role of the pathogenesis of obesity, and hypertension may underpin the development of cardiovascular events. In the present study, we evaluated the effects of weight loss (WL) on renal function, especially focusing on sympathetic nervous activity. In 154 overweight or obese Japanese men (89 normotensive and 65 untreated mild hypertensive subjects), body weight, body mass index (BMI), total body fat mass, blood pressure (BP), serum creatinine, blood urea nitrogen, creatinine clearance (CCr) (calculated with the Cockcroft-Gault equation) and plasma norepinephrine (NE) were measured before and after a 12-month period of WL with a mild caloric-restricted diet and exercise. A significant WL was defined as 10% or more WL compared with the entry period. In total, 97 (63.0%) subjects succeeded in significant (by 14.3%) WL at 12 months, and 57 subjects (37.0%) did not succeed in significant WL but they lost 7.7% weight. At entry, levels of plasma NE, serum creatinine and fat mass were significantly lower and CCr was greater in the group with a significant WL compared with those without WL. BMI, total body fat mass and plasma NE significantly decreased, and CCr increased with WL. At both baseline and at the 12-month period, fat mass and plasma NE negatively correlated with CCr and positively correlated with creatinine at each time point. Changes in fat mass and plasma NE over 12 months correlated with changes in creatinine, and only changes in fat mass negatively correlated with changes in CCr. Basal fat mass and plasma NE correlated positively with serum creatinine at 12 months and negatively with CCr at the same time point. In multiple regression analyses, basal plasma NE and fat mass were significant determinants of serum creatinine levels and CCr at 12 months.In conclusion, WL improved renal function (as evident from measures of creatinine and CCr) in overweight individuals. Basal plasma NE levels and total body fat mass could be predictors for improvement in renal function associated with WL. Suppression of sympathetic nervous activation associated with WL may have a role in the ameliorative effects on renal function.

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Section: Introductionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of weight loss on renal function in overweight Japanese men

et al. 2011

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“…It is widely recognized that insulin resistance or hyperinsulinemia and sympathetic nervous activation relates to obesity and hypertension, 1-5 and these are known to be independent risk factors for future cardiovascular events. [6][7][8][9] Weight loss is an important preventative measure and is associated with a reduction in all-cause mortality. 10 Weight loss associated with lifestyle modifications such as diet and regular exercise are important and remain the first-line treatment for obesity and obesity-related hypertension.…”

Section: Introductionmentioning

confidence: 99%

Different mechanisms in weight loss-induced blood pressure reduction between a calorie-restricted diet and exercise

et al. 2011

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The present study compared the effectiveness of a mild calorie-restricted diet (D) alone, exercise (EX) alone and a combination of D+EX on weight loss-induced blood pressure (BP) reduction over 24 weeks. We focussed especially on the relationship between sympathetic nervous activity, as indicated from measures of plasma norepinephrine (NE), and insulin resistance (homeostasis model of insulin resistance, HOMA-IR). The three groups each comprised 30 obese, hypertensive men. Body mass index (BMI), fat mass, waist-to-hip ratio, BP, plasma NE and HOMA-IR were measured every 2 weeks during the first 4 weeks and subsequently every 4 weeks for the next 20 weeks. All basal parameters were similar among the three groups. At 24 weeks, the combination group with D+EX comprised a significantly higher prevalence of normotensive subjects than the D alone or EX alone group (Po0.05). In the D alone group, plasma NE was decreased significantly at 2 weeks, reductions in BMI, fat mass and BP were observed at 8 weeks, and waist-to-hip ratios and HOMA-IR were decreased at 12 weeks. In comparison, in the EX alone group, significant reductions of fat mass and HOMA-IR were observed at 4 weeks. Plasma NE and HOMA-IR were reduced at 8 weeks while decreases in BP were detected at 12 weeks. In the D+EX group, significant reductions in plasma NE were observed at 2 weeks followed by significant decreases in BMI, fat mass, waist-to-hip ratio, BP levels and HOMA-IR at 4 weeks. The magnitudes of reductions of all parameters were greatest in the D+EX group. These results demonstrate that D+EX exerts a stronger ameliorative effect on weight loss, weight loss-induced BP reduction, normalization of BP, sympathetic activation and insulin resistance compared with D or EX alone. D and EX might, perhaps, exert different mechanisms on weight loss and weight loss-induced BP reduction; however, a combination of caloric restriction and exercise is preferred to control BP levels in obese hypertensive patients.

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The Potential Role of Catheter-Based Renal Sympathetic Denervation in Chronic and End-Stage Kidney Disease

Schlaich¹,

Sata²

2014

Renal Denervation

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High Plasma Norepinephrine Levels Associated with .BETA.2-Adrenoceptor Polymorphisms Predict Future Renal Damage in Nonobese Normotensive Individuals

Cited by 23 publications

References 35 publications

Effects of weight loss on renal function in overweight Japanese men

Effects of weight loss on renal function in overweight Japanese men

Different mechanisms in weight loss-induced blood pressure reduction between a calorie-restricted diet and exercise

The Potential Role of Catheter-Based Renal Sympathetic Denervation in Chronic and End-Stage Kidney Disease

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