Flexible tribovoltaic direct-current (DC) generators are urgently expected by wearable applications. Traditional rigid contact-separation type tribovoltaic DC generators normally have non-ignorable friction loss and cannot sustain outstanding outputs. This hinders their serviceability in continuous motion scenarios. Here, flexible liquid-based DC generators (FLGs) with metalliquid-semiconductor indium gallium zinc oxide (IGZO) stack structures are reported. The FLG with Pt/H 2 O/IGZO structure delivers a peak short-circuit current density up to 2.3 µA cm −2 , a peak open-circuit voltage up to 620 mV, and a power density up to 0.1 µW cm −2 . The differences in the properties of different liquid-solid interfaces are studied by density functional theory, showing that the bond formation, charge-transfer-induced dipole electric field at the solid-liquid interface, and the built-in electric field are responsible for the generation and separation of electron-hole pairs to form continuous DC. The proposed FLG can keep excellent performance even after >5 × 10 4 shaking cycles or exposing to ambient conditions for 30 days, showing extraordinary stability. Besides charging capacitors or driving LEDs, the FLG is further demonstrated to work for self-powered multifunctional sensing, enabling pressure, position-posture, or temperature detections. This design offers potential solutions and novel possibilities for next-generation self-powered wearable electronics.